定量方法
Motivated by the current COVID-19 health-crisis, we examine the task of baseline subtraction for quantitative polymerase chain-reaction (qPCR) measurements. In particular, we present an algorithm that leverages information obtained from…
The novel coronavirus (2019-nCoV) has been declared to be a new international health emergence and no specific drug has been yet identified. Several methods are currently being evaluated such as protease and glycosylated spike (S) protein…
Diseases involve complex processes and modifications to the cellular machinery. The gene expression profile of the affected cells contains characteristic patterns linked to a disease. Hence, biological knowledge pertaining to a disease can…
Translating biomedical ontologies is an important challenge, but doing it manually requires much time and money. We study the possibility to use open-source knowledge bases to translate biomedical ontologies. We focus on two aspects:…
Fast testing can help mitigate the coronavirus disease 2019 (COVID-19) pandemic. Despite their accuracy for single sample analysis, infectious diseases diagnostic tools, like RT-PCR, require substantial resources to test large populations.…
In 2000, Gillespie rehabilitated the chemical Langevin equation (CLE) by describing two conditions that must be satisfied for it yield a valid approximation of the chemical master equation (CME). In this work, we construct an original path…
Objective. We identify two linked problems related to estimating the phase of the alpha rhythm when the signal after a specific event is unknown (real-time case), or corrupted (offline analysis). We propose methods to estimate the phase…
The life of a cell is governed by highly dynamical microscopic processes. Two notable examples are the diffusion of membrane receptors and the kinetics of transcription factors governing the rates of gene expression. Different fluorescence…
Predicting whether a chemical structure shares a desired biological effect can have a significant impact for in-silico compound screening in early drug discovery. In this study, we developed a deep learning model where compound structures…
In the context of natural-based wastewater treatment technologies (such as constructed wetlands - CW) the use of a low-cost, continuous-like biosensor tool for the assessment of operational conditions is of key importance for plant…
This two-part review examines how automation has contributed to different aspects of discovery in the chemical sciences. In this second part, we reflect on a selection of exemplary studies. It is increasingly important to articulate what…
This two-part review examines how automation has contributed to different aspects of discovery in the chemical sciences. In this first part, we describe a classification for discoveries of physical matter (molecules, materials, devices),…
The rapid growth in biological sequence data is revolutionizing our understanding of genotypic diversity and challenging conventional approaches to informatics. With the increasing availability of genomic data, traditional bioinformatic…
Cells exhibit a wide variety of different shapes. This diversity poses a challenge for computational approaches that attempt to shed light on the role cell geometry plays in regulating cell physiology and behavior. The simulation platform…
The appearance of a new dangerous and contagious disease requires the development of a drug therapy faster than what is foreseen by usual mechanisms. Many drug therapy developments consist in investigating through different clinical trials…
Models of radiative transfer (RT) are important tools for remote sensing of vegetation, as they facilitate forward simulations of remotely sensed data as well as inverse estimation of biophysical and biochemical properties from vegetation…
Conditions such as insomnia, cardiac arrhythmia and jet-lag share a common feature: they are all related to the ability of biological systems to synchronize with the day-night cycle. When organisms lose resilience, this ability of…
The rapid increase of transportation infrastructure during the recent decades has caused a number of effects on bird species, including collision mortality, habitat loss, fragmentation and noise. This paper investigates the effects of…
We give a short introduction to cough detection efforts that were undertaken during the last decade and we describe the solution for automatic cough detection developed for the AioCare portable spirometry system. In contrast to more popular…
As synchronized activity is associated with basic brain functions and pathological states, spike train synchrony has become an important measure to analyze experimental neuronal data. Many different measures of spike train synchrony have…