其他定量生物学
Suillus species, in general, are edible mushrooms, and environmentally important that are associated mostly with pine trees in the tropics regions. These fungi considered a remarkable source of phenolic compounds that play a crucial role as…
Hepatitis A virus (HAV) infection has been greatly reduced in most developed countries through the use of vaccine and improved hygienic conditions. However, the magnitude of the problem is underestimated and there are no well-established…
Analyzing proteins from single cells by tandem mass spectrometry (MS) has become technically feasible. While such analysis has the potential to accurately quantify thousands of proteins across thousands of single cells, the accuracy and…
The objective of this project is to develop an automated device used to spot protein samples on a hydrophobic membrane to be used for the patented electrophoresis method developed by Chang and Yonan in 2008 [1]. This novel method performs…
Standardization of data items collected in paediatric clinical trials is an important but challenging issue. The Clinical Data Interchange Standards Consortium (CDISC) data standards are well understood by the pharmaceutical industry but…
A MCMC approach is used to estimate the age-specific mortality rate ratio for German men and women with RA. For constructing priors, we calculate a range of admissible values from prevalence and incidence data based on about 60 million…
Objective: To discover biomarkers and uncover the mechanism of Cold/Hot ZHENG (syndrome in traditional Chinese medicine) chronic gastritis (CG) and Cold/Hot herbs in traditional Chinese medicine (TCM) formulae on systematic biology.…
TRPC(3,6) are two ~ 930 amino acid membrane proteins that form calcium permeant cation channels. Here we examine the differences between mammals and oviparous species. Our method is based on the concept of evolution towards criticality, a…
Academic medical centers are generating an increasing amount of biomedical data and there is an increasing demand for biomedical data for research purposes by research projects, research consortia, companies, and other third parties. At the…
The coronavirus pandemic (COVID) has been an extraordinary test of modern government scientific procedures that inform and shape policy. Many governments implemented COVID quarantine (stay-at-home) orders on the notion that this…
Cancer, as the uncontrollable cell growth, is related to many branches of biology. In this review, we will discuss three mathematical approaches for studying cancer biology: population dynamics, gene regulation, and developmental biology.…
The major intrinsic protein (MIP) of the lens fiber cell membrane plays a role in lens biogenesis and maintenance. Its polypeptide chains span the membrane six times, and the protein is naturally divided into two halves. We use modern…
In this paper, we use Kansa method for solving the system of differential equations in the area of biology. One of the challenges in Kansa method is picking out an optimum value for Shape parameter in Radial Basis Function to achieve the…
Quantifying the dynamics of tumor burden reveals useful information about cancer evolution concerning treatment effects and drug resistance, which play a crucial role in advancing model-informed drug developments (MIDD) towards personalized…
Experimental data were used to support a new concept of osmotic force and a new osmotic law that can explain the osmotic process without the difficulties encountered with van't Hoff osmotic pressure theory. Derived new osmotic formula with…
Because of their large size and widespread mechanosensitive interactions the only recently discovered titled transmembrane proteins have attracted much attention. Here we present and discuss their hydropathic profiles using a new method of…
The past few decades have seen great leaps in technologies to analyze cells and tissues. Omics methods in particular now allow us unprecedented access to their the molecular composition where the base-level resolution of transcripts and…
This Special Issue of Biomolecules, commissioned in honor of Dr. Philip E. Bourne, focuses on a new field of biomolecular data science. In this brief retrospective, we consider the arc of Bourne's 40-year scientific and professional career,…
Significantly higher transmissibility of SARS CoV-2 (2019) compared to SARS CoV (2003) can be attributed to mutations of structural proteins (Spike S, Nucleocapsid N, Membrane M, and Envelope E) and the role played by non-structural…
What is behind the \emph{wisdom of the crowds} described by Simons (2004)? It has been showed that insects may use gravitational fields to travel (Dreyer et al 2018) and we may ask whether the use of gravitational fields is enough to secure…