医学物理
Machine learning (ML) has been increasingly used to quantify chemical exchange saturation transfer (CEST) effect. ML models are typically trained using either measured data or fully simulated data. However, training with measured data often…
OBJECTIVE: Assessing the biomechanical behaviour of the aortic wall in vivo can potentially improve the diagnosis and prognosis of patients with abdominal aortic aneurysms (AAA). With ultrasound, AAA wall stiffness can be estimated as the…
In this work, we propose a new computing process, named DeepBEVdose, which is essentially distinct to the previous deep learning-based dose calculation methods.We present a novel image-domain dose calculation algorithm to automatically…
Purpose: To derive kinetic equations for multi-compartmental contrast agent distribution from first principles and apply it to two and three compartments for Gd-EOB-DTPA using low time resolution human liver DCE-MRI data. Methods: The…
Optical tomography has emerged as a non-invasive imaging method, providing three-dimensional insights into subcellular structures and thereby enabling a deeper understanding of cellular functions, interactions, and processes. Conventional…
Purpose: To explore efficient encoding schemes for quantitative magnetization transfer (qMT) imaging with few constraints on model Theory and Methods: We combine two recently proposed models in a Bloch-McConnell equation: the dynamics of…
Arrhythmia of the heart is a dangerous and potentially fatal condition. The current widely used treatment is the implantable cardioverter defibrillator (ICD), but it is invasive and affects the patient's quality of life. The sonogenetic…
Estimating the travel time of ultrasound in an inhomogeneous medium is crucial for high-quality imaging, as with an accurate estimate of the distribution of speed of sound, phase aberration, which is normally viewed as one of the reasons…
Purpose To achieve whole-liver motion-corrected fat fraction (FF) and R2* quantification with a 3-minute free-breathing (FB) 3D radial isotropic acquisition, for increased organ coverage, ease-of-use, and patient comfort. Methods A FB 3D…
Percutaneous catheter pumps are intraventricular temporary mechanical circulatory support (MCS) devices that are positioned across the aortic valve into the left ventricle (LV) and provide continuous antegrade blood flow from the LV into…
Higher frequencies and shorter wavelengths present significant design issues at ultra-high fields, making multi-channel array setup a critical component for ultra-high field MR imaging. The requirement for multi-channel arrays, as well as…
Finite element analysis of soft tissues is a well-developed method that allows estimation of mechanical quantities (e.g. stresses, strains). A constitutive law has to be used to characterise the individual tissues. This is complex as…
X-ray diffusive dark-field imaging, which allows spatially unresolved microstructure to be mapped across a sample, is an increasingly popular tool in an array of settings. Here, we present a new algorithm for phase and dark-field computed…
Purpose: This study assesses the effectiveness of Deep Learning (DL) for creating synthetic CT (sCT) images in MR-guided adaptive radiation therapy (MRgART). Methods: A Cycle-GAN model was trained with MRI and CT scan slices from MR-LINAC…
Recent development of photon-counting CT (PCCT) brings great opportunities for plaque characterization with much-improved spatial resolution and spectral imaging capability. While existing coronary plaque PCCT imaging results are based on…
Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…
Purpose: Prior AI-based dose prediction studies in photon and proton therapy often neglect underlying physics, limiting their generalizability to handle outlier clinical cases, especially for pencil beam scanning proton therapy (PBSPT). Our…
The substantial computational cost of high-fidelity models in numerical hemodynamics has, so far, relegated their use mainly to offline treatment planning. New breakthroughs in data-driven architectures and optimization techniques for fast…
Dynamic cone-beam computed tomography (CBCT) can capture high-spatial-resolution, time-varying images for motion monitoring, patient setup, and adaptive planning of radiotherapy. However, dynamic CBCT reconstruction is an extremely…
Purpose: Sodium MRI is challenging because of the low tissue concentration of the 23 Na nucleus and its extremely fast biexponential transverse relaxation rate. In this article, we present an iterative reconstruction framework using…