医学物理
Hyperpolarized (HP) 13C MRI has shown promise as a valuable modality for in vivo measurements of metabolism and is currently in human trials at 15 research sites worldwide. With this growth it is important to adopt standardized data storage…
Magnetocardiography (MCG) has emerged as a sensitive and precise method to diagnose cardiovascular diseases, providing more diagnostic information than traditional technology. However, the sensor limitations of conventional MCG systems,…
In recent years, a novel x-ray imaging modality has emerged that reveals unresolved sample microstructure via a "dark-field image", which provides complementary information to conventional "bright-field" images, such as attenuation and…
Purpose: To develop neural network (NN)-based quantitative MRI parameter estimators with minimal bias and a variance close to the Cram\'er-Rao bound. Theory and Methods: We generalize the mean squared error loss to control the bias and…
Background: X-ray grating-based dark-field imaging can sense the small angle scattering caused by an object's micro-structure. This technique is sensitive to lung's porous alveoli and is able to detect lung disease at an early stage. Up to…
Breast cancer, the second most prevalent cancer among women worldwide, necessitates the exploration of novel therapeutic approaches. To target the four subgroups of breast cancer "hormone receptor-positive and HER2-negative, hormone…
AI is revolutionizing MRI along the acquisition and processing chain. Advanced AI frameworks have been developed to apply AI in various successive tasks, such as image reconstruction, quantitative parameter map estimation, and image…
This paper presents a method for the fast and accurate estimation of the gain pattern and maximum gain of an implanted antenna including the effect of the host body, under the assumption that the latter is electrically large. The estimation…
Pathological features are the gold standard for tumor diagnosis, guiding treatment and prognosis. However, standard histopathological process is labor-intensive and time-consuming, while frozen sections have lower accuracy. Dynamic…
Purpose: To employ optimal control for the numerical design of CEST saturation pulses to maximize contrast and stability against $B_0$ inhomogeneities. Theory and Methods: We applied an optimal control framework for the design pulse shapes…
Magnetic resonance imaging (MRI) is fundamental for the assessment of many diseases, due to its excellent tissue contrast characterization. This is based on quantitative techniques, such as T1 , T2 , and T2* mapping. Quantitative MRI…
Excess mortality is defined as an increase in the number of deaths above what is expected based on historical trends, hereafter called baseline. In a previous paper, we introduced a statistical method that allows an unbiased and robust…
The cornea, as the outer element of the human eye, plays a pivotal role in vision. Any defects in its shape can result in visual impairments. Mechanical defect manifest as shape defects, as the cornea is under to pressure. Our study…
Purpose: In the recent past, spin-locking MRI experiments were successfully applied for the direct detection of sinusoidal magnetic field oscillations in the sub-nT range. In the present study, this detection approach was extended to…
Magnetic particle imaging (MPI) is an in-vivo imaging method to detect magnetic nanoparticles for blood vessel imaging and molecular target imaging. Compared with conventional molecular imaging devices (such as nuclear medicine imaging PET…
Biophysical models of diffusion tailored to quantify gray matter microstructure are gathering increasing interest. The two-compartment Neurite EXchange Imaging ($NEXI$) model has been proposed recently to account for neurites,…
Reducing proton treatment time improves patient comfort and decreases the risk of error from intra-fractional motion, but must be balanced against clinical goals and treatment plan quality. We formulated the proton treatment planning…
The purpose was to investigate the spatial heterogeneity of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) uptake within parotid glands. We aim to quantify patterns in well-defined regions to facilitate further…
We introduce a novel method to design and implement a tunable dynamical tissue phantom for laser speckle-based in-vivo blood flow imaging. This approach relies on Stochastic Differential Equations (SDE) to control a piezoelectric actuator…
This article examines the critical role of fast Monte Carlo dose calculations in advancing proton therapy techniques, particularly in the context of increasing treatment customization and precision. As adaptive radiotherapy and other…