医学物理
Analysing the haemodynamics of flow in carotid artery disease serves as a means to better understand the development and progression of associated complex diseases. Carotid artery disease can predispose people to major adverse…
X-ray computed tomography (CT) is widely utilized in the medical, industrial, and other fields to nondestructively generate three-dimensional structural images of objects. However, CT images are often affected by various artifacts, with…
This research aims to develop a method to reduce the time cost and complexity of balloon expandable stent simulations in cardiovascular stenting procedures for Peripheral Artery Disease. The study uses stereoscopic images to construct a…
Magnetic Particle Imaging (MPI) is a tomographic imaging modality capable of real-time, high-sensitivity mapping of superparamagnetic iron oxide nanoparticles. Model-based image reconstruction provides an alternative to conventional methods…
Ensuring diagnostic performance of AI models before clinical use is key to the safe and successful adoption of these technologies. Studies reporting AI applied to digital pathology images for diagnostic purposes have rapidly increased in…
Cardiac resynchronization therapy (CRT) guidelines are based on clinical trials with limited female representation and inconsistent left bundle branch block (LBBB) definitions. Conventional QRS duration (QRSd) criteria show variable…
As depth increases, linear energy transfer (LET) rises toward the distal edge of the Bragg peak, boosting the radiobiological effectiveness (RBE). To manage the biological variation and limit normal-tissue damage, LET-modifying objective…
We present the first acquisition-agnostic diffusion generative model for Magnetic Resonance Imaging (MRI) in the neonatal intensive care unit (NICU) to solve a range of inverse problems for shortening scan time and improving motion…
Coronary heart disease (CHD) remains a leading cause of mortality worldwide. This study introduces a novel approach that integrates patient-specific Multi-slice CT scans into CAD models, using a one-dimensional numerical framework to assess…
Lattice radiotherapy (LATTICE) is a form of spatially fractionated radiation therapy (SFRT) designed to deliver high doses to tumor regions while sparing surrounding tissues. Traditional LATTICE uses rigid vertex patterns, limiting…
In this study, we explore the use of Co-55 as a radioisotope for multiplexed PET (mPET) by utilizing its emission of a prompt gamma-ray in cascade with a positron during decay. We leverage the prompt-gamma signal to generate triple…
Purpose: To develop a fat-water separation approach that corrects bipolar readout gradient induced effects, without additional scans, that is compatible with any fat-water separation method. Theory and Methods: The proposed approach…
Optical transmission spectroscopy is one method to understand brain tissue structural properties from brain tissue biopsy samples, yet manual interpretation is resource intensive and prone to inter observer variability. Deep convolutional…
In recent literature, the output correction factor in a 1.5T magnetic field, kB,Q,Clin, were determined only for the central axis (CAX), including our last work. At an MR-linac, the determination of the CAX position relies on e.g.…
The regulation of intestinal blood flow is critical to gastrointestinal function. Imaging the intestinal mucosal micro-circulation in vivo has the potential to provide new insight into the gut physiology and pathophysiology. We aimed to…
Electrical impedance tomography (EIT) is a novel computational imaging technology. In order to improve the quality and spatial resolution of the reconstructed images, the G-CNN and HG-CNN algorithms are proposed based on a one-dimensional…
PET is affected by statistical noise due to constraints on tracer dose and scan duration, impacting both diagnostic performance and quantitative accuracy. While deep learning (DL)-based PET denoising methods have been used to improve image…
Targeted alpha-particle therapy (TAT) employs alpha-emitting radionuclides conjugated to tumor-targeting molecules to deliver localized radiation to cancer cells, showing great promise in treating metastatic cancers. Among these…
Ovarian cancer remains a challenging malignancy to diagnose and manage, with prognosis heavily dependent on the stage at detection. Accurate grading and staging, primarily based on histopathological examination of biopsy tissue samples, are…
Effective education in radiotherapy plan quality review requires a robust, regularly updated set of examples and the flexibility to demonstrate multiple possible planning approaches and their consequences. However, the current clinic-based…