医学物理
Quantitative measures of dopamine transporter (DaT) uptake in caudate, putamen, and globus pallidus derived from DaT-single-photon emission computed tomography (SPECT) images are being investigated as biomarkers to diagnose, assess disease…
In the early days of space exploration, when Sally Ride was offered 100 tampons for a week-long mission, menstrual medical devices first began to be used in space conditions. Since then, hormonal menstrual suppression has become the…
Elucidating the biomechanical behavior of the myocardium is crucial for understanding cardiac physiology, but cannot be directly inferred from clinical imaging and typically requires finite element (FE) simulations. However, conventional FE…
Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…
Studying the peeling behaviour of adhesives on skin is vital for advancing biomedical applications such as medical adhesives and transdermal patches. Traditional methods like experimental testing and finite element method (FEM), though…
Time-dependent diffusion MRI (dMRI) with single diffusion encoding (SDE) probes water dynamics in biological tissues, but signal interpretation depends on microstructure. While prior work focused on restricted/hindered diffusion and…
Tissue viscoelasticity has been recognized as a crucial biomechanical indicator for disease diagnosis and therapeutic monitoring. Conventional shear wave elastography techniques depend on dispersion analysis and face fundamental limitations…
Deformable liver motion tracking using a single X-ray projection enables real-time motion monitoring and treatment intervention. We introduce a conditional point cloud diffusion model-based framework for accurate and robust liver motion…
Structured illumination microscopy (SIM) is one of the most versatile super-resolution techniques. Yet, its application to live imaging has been so far mainly limited to fluorescent and stationary specimens. Here, we present advancements in…
Improving effective treatment plans in carbon ion therapy, especially for targeting radioresistant tumors located in deep seated regions while sparing normal tissues, depends on a precise and computationally efficient dose calculation…
This work presents a preliminary evaluation of the use of the convolutional neural network nnU-NET to automatically contour the volume of Glioblastoma Multiforme in medical images of patients. The goal is to assist the preparation of the…
Personalized precision radiation therapy requires more than simple classification, it demands the identification of prognostic, spatially informative features and the ability to adapt treatment based on individual response. This study…
Radiation therapy outcomes are decided by two key parameters, dose and timing, whose best values vary substantially across patients. This variability is especially critical in the treatment of brain cancer, where fractionated or staged…
Precise radiation delivery is critical for effective radiotherapy, and gold nanoparticles (AuNPs) have emerged as promising tools to enhance local dose deposition while sparing the surrounding healthy tissue. In this study, the PENELOPE…
Radiochromic films (RCFs) offer valuable two-dimensional dosimetry capabilities with a conceptually simple operating principle that requires minimal investment, making them particularly suitable for very high energy electron (VHEE) FLASH…
{\bf Purpose:} This study evaluates a compact biocompatible Seven-probe Scintillator Detector (7SD) for monitoring HDR-BT treatment sequences across a range of dwell times and source-probe spacings representative of most HDR-BT techniques.…
This paper presents a novel image reconstruction pipeline for three-gamma (3-{\gamma}) positron emission tomography (PET) aimed at improving spatial resolution and reducing noise in nuclear medicine; the proposed Direct3{\gamma} pipeline…
In this study, we introduce a Compton SPECT system for whole-body imaging of Actinium-225 (225Ac), one of the trending radionuclides for targeted alpha therapy (TAT). The Compton SPECT system enables multi-energy gamma photon detection with…
This study aims to develop a digital twin (DT) framework to enhance adaptive proton stereotactic body radiation therapy (SBRT) for prostate cancer. Prostate SBRT has emerged as a leading option for external beam radiotherapy due to its…
Online adaptive proton therapy (APT) is an ideal solution theoretically, which however is challenging to proton clinics. Although multiple groups have been endeavoring to develop online APT technology, there is a concern in the radiotherapy…