医学物理
The physical basis and algorithm of the ultraviolet germicidal irradiation (UVGI) scientific calculator are presented herein. The algorithm was implemented in the web application UVGI Scientific Calculator (found at…
Current pathology workflow involves staining of thin tissue slices, which otherwise would be transparent, followed by manual investigation under the microscope by a trained pathologist. While the hematoxylin and eosin (H&E) stain is…
Nuclear magnetic resonance spectroscopy (MRS) allows for the determination of atomic structures and concentrations of different chemicals in a biochemical sample of interest. MRS is used in vivo clinically to aid in the diagnosis of several…
Deep learning-based fluence map prediction(DL-FMP) method has been reported in the literature, which generated fluence maps for desired dose by deep neural network(DNN)-based inverse mapping. We hypothesized that DL-FMP is similar to…
Background: Magnetization transfer (MT) saturation reflects the additional saturation of the MRI signal imposed by an MT pulse and is largely driven by the saturation of the bound pool. This reduction of the bound polarization by the MT…
A novel method for automated assessment of directions of collagen fibers in soft tissues is presented. It is based on multiple rotated images obtained via polarized light microscope with perpendicular and inclined polarizers and thus it…
In this work, we have investigated a number of unsupervised learning methods for material segmentation in projection x-ray imaging with a spectral detector. A phantom containing two hard materials (glass, steel) and three soft materials…
Range verification of clinical protontherapy systems via positron-emission tomography (PET) still suffers from insufficient signal from low-energy protons around the Bragg peak and biological washout of PET emitters. Here we investigate the…
Presently 4T-1 luc cells were irradiated with proton under ultra-high dose rate FLASH or with gamma-ray with conventional dose rate, and then subcutaneous vaccination with or without Mn immuno-enhancing adjuvant into the mice for three…
Early diagnosis of ocular diseases improves the understanding of pathophysiology and helps with accurate monitoring and effective treatment. Advanced multimodal ocular imaging platforms play a crucial role in the visualization of the ocular…
Precise quantitative delineation of tumor hypoxia is essential in radiation therapy treatment planning to improve the treatment efficacy by targeting hypoxic sub-volumes. We developed a combined imaging system of positron emission…
Using high frame-rate ultrasound and high sensitivity motion tracking, we recently showed that shear waves sent to the ex vivo porcine brain develop into shear shock waves with destructive local accelerations inside the brain which may be a…
Shear shocks, which exist in a completely different regime from compressional shocks, were recently observed in the brain. These low phase speed ($\approx$ 2 m/s) high Mach number ($\approx$ 1) waves could be the primary mechanism behind…
Accurate segmentation of prostate and surrounding organs at risk is important for prostate cancer radiotherapy treatment planning. We present a fully automated workflow for male pelvic CT image segmentation using deep learning. The…
Although close contact represents an important contagion route, the mechanism of exposure to exhaled droplets remains insufficiently characterized. In this study, an integrated risk assessment is presented for SARS-CoV-2 close contact…
X-ray CT dose measurement has mainly been performed using an ionization chamber dosimeter. Therefore, the dose distribution has not been sufficiently studied. We investigated the importance of evaluating the two or three-dimensional dose…
The non-contact infrared thermometer (NCIT) is an important basic tool for fever screening and self-health monitoring. However, it is susceptible to the thermal shock when working in a low temperature environment, which will cause a…
Electroencephalogram (EEG) monitoring and objective seizure identification is an essential clinical investigation for some patients with epilepsy. Accurate annotation is done through a time-consuming process by EEG specialists.…
Purpose: Eddy currents might lead to image distortions in diffusion weighted echo planar imaging. A method is proposed to reduce their effects on double diffusion encoding (DDE) MRI experiments and the thereby derived microscopic fractional…
Purpose: Using linear transformation of the data allows studying detectability of an imaging system on a large number of signals. An appropriate transformation will produce a set of signals with different contrast and different frequency…