医学物理
Background: Synthetic computed tomography (sCT) has been proposed and increasingly clinically adopted to enable magnetic resonance imaging (MRI)-based radiotherapy. Deep learning (DL) has recently demonstrated the ability to generate…
Optical coherence tomography (OCT) has stimulated a wide range of medical image-based diagnosis and treatment in fields such as cardiology and ophthalmology. Such applications can be further facilitated by deep learning-based…
An electrocardiogram (ECG) monitors the electrical activity generated by the heart and is used to detect fatal cardiovascular diseases (CVDs). Conventionally, to capture the precise electrical activity, clinical experts use multiple-lead…
One of the challenges in the development of patient-specific models of cardiac arrhythmias for clinical applications has been accounting for myocardial fiber organization. The fiber varies significantly from heart to heart, but cannot be…
Efficient and accurate evaluation of long-term photoplethysmography (PPG) recordings is essential for both clinical assessments and consumer products. In 2021, the top opensource peak detectors were benchmarked on the Multi-Ethnic Study of…
Premature births can lead to complications, with fetal lung immaturity being a primary concern. Currently, fetal lung maturity (FLM) requires an invasive surfactant extraction procedure between the 32nd and 39th weeks of pregnancy.…
Purpose: Development of a generic model-based reconstruction framework for multi-parametric quantitative MRI that can be used with data from different pulse sequences. Methods: Generic nonlinear model-based reconstruction for quantitative…
Diabetic foot ulcers are triggered by mechanical loadings applied to the surface of the plantar skin. Strain is considered to play a crucial role in relation to ulcer etiology and can be assessed by Finite Element (FE) modelling. A…
The high speed of cardiorespiratory motion introduces a unique challenge for cardiac stereotactic radio-ablation (STAR) treatments with the MR-linac. Such treatments require tracking myocardial landmarks with a maximum latency of 100 ms,…
Fast dose calculation is critical for online and real time adaptive therapy workflows. While modern physics-based dose algorithms must compromise accuracy to achieve low computation times, deep learning models can potentially perform dose…
Ultra-high dose rate (FLASH) proton planning with only transmission beams (TBs) has limitations in normal tissue sparing. The single-energy spread-out Bragg peaks (SESOBPs) of FLASH dose rate have been demonstrated feasible for proton FLASH…
While optical coherence tomography (OCT) provides a resolution down to 1 micrometer it has difficulties to visualize cellular structures due to a lack of scattering contrast. By evaluating signal fluctuations, a significant contrast…
Conventional planning objectives in optimization of intensity-modulated radiotherapy treatment (IMRT) plans are designed to minimize the violation of dose-volume histogram (DVH) thresholds using penalty functions. Although successful in…
Radiation damping (RD) has been shown to affect T1 measurement in inversion recovery experiments. In this work, we demonstrate that the extent of RD depends upon the T1 of the sample. RD difference spectroscopy (RADDSY) is used to…
Positron Emission Tomography (PET) scanners are usually designed with the goal to obtain the best compromise between sensitivity, resolution, field-of-view size, and cost. Therefore, it is difficult to improve the resolution of a PET…
Purpose: To develop and evaluate a cardiovascular magnetic resonance sequence (MyoFold) for rapid myocardial tissue and movement characterization. Method: MyoFold sequentially performs joint T1/T2 mapping and cine for one left-ventricle…
In this work, the induction and repair of radiation-induced 53BP1 foci were studied in human umbilical vein endothelial cells irradiated at the PTB microbeam with protons and {\alpha}-particles of different energies. The data were analyzed…
Purpose: Highlight the distinctions, both in terms of concept and numerical values, of the various definitions that can be established for the dose rate in PBS proton therapy. Methods: In an in silico study, five definitions of the dose…
The big crux with drug delivery to human lungs is that the delivered dose at the local site of action is unpredictable and very difficult to measure, even a posteriori. It is highly subject-specific as it depends on lung morphology,…
Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the…