生物物理
Active walker models have proved to be extremely effective in understanding the evolution of a large class of systems in biology like ant trail formation and pedestrian trails. We propose a simple model of a random walker which modifies its…
In spite of the crucial role it is believed to play in nature, fluorescence in natural organisms remains under-investigated from optical, chemical and biological perspectives. One example is the transparent wings of insects from the order…
In our previous paper, the logistic curve of the removed number was derived from SIR and SEIR models in the case of the small basic reproduction number. In this paper, we derive various logistic curves of the removed, unsusceptible and…
Living cells can leverage correlations in environmental fluctuations to predict the future environment and mount a response ahead of time. To this end, cells need to encode the past signal into the output of the intracellular network from…
The oldest forms of living organisms on Earth are about 3.5 billion years old, and they are found in hydrothermal deposits, and it is often hypothesized that life originated there. But the hydrothermal systems with a fairly strong flow of…
Proteolysis targeting chimera (PROTAC) is a novel drug modality that facilitates the degradation of a target protein by inducing proximity with an E3 ligase. In this work, we present a new computational framework to model the cooperativity…
Bone health related skeletal disorders are commonly diagnosed by X-ray imaging, but the radiation limits its use. Light excitation and optical imaging through the near-infrared-II window (NIR-II, 1000-1700 nm) can penetrate deep tissues…
External gradients can strongly influence the collective behavior of microswimmers. In this paper, we study the behavior of two hydrodynamically interacting self-propelled chiral swimmers, in the low-Reynolds number regime, under the…
Diffusion Magnetic Resonance Imaging (dMRI) is an imaging technique with exquisite sensitivity to the microstructural properties of heterogeneous media. The conventionally adopted acquisition schemes involving single pulsed field gradients…
We report a new approach to controllable thermal stimulation of a single living cell and its compartments. The technique is based on the use of a single polycrystalline diamond particle containing silicon-vacancy (SiV) color centers. Due to…
The mechanisms by which a protein's 3D structure can be determined based on its amino acid sequence have long been one of the key mysteries of biophysics. Often simplistic models, such as those derived from geometric constraints, capture…
High traffic touch surfaces such as doorknobs, countertops, and handrails can be transmission points for the spread of pathogens, emphasizing the need to develop materials that actively self-sanitize. Metals are frequently used for these…
The mechanism of avian navigation is an important question for global scientists. One of the most famous candidates is the radical pair mechanism (RPM), which shows that avian navigation is achieved by detecting the amount of products from…
Nanoswimmers are ubiquitous in bio- and nano-technology but are extremely challenging to measure due to their minute size and driving forces. A simple method is proposed for detecting the elusive physical features of nanoswimmers by…
We investigate pattern formation in a two-dimensional (2D) Fisher--Stefan model, which involves solving the Fisher--KPP equation on a compactly-supported region with a moving boundary. By combining the Fisher--KPP and classical Stefan…
Molecular motors belonging to the kinesin and myosin super family hydrolyze ATP by cycling through a sequence of chemical states. These cytoplasmic motors are dimers made up of two linked identical monomeric globular proteins. Fueled by the…
A fundamental question regarding biological transport networks is the interplay between the network development or reorganization and the flows it carries. We use Physarum polycephalum, a true slime mould with a transport network which…
Information of relevance to the organism often is represented by the concentrations of particular molecules inside a cell. As outside observers we can now measure these concentrations precisely, but the cell's own mechanisms must be…
Biofilms pose significant problems for engineers in diverse fields, such as marine science, bioenergy, and biomedicine, where effective biofilm control is a long-term goal. The adhesion and surface mechanics of biofilms play crucial roles…
Significance: Multiple eye diseases such as age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa can cause photoreceptor dysfunction. Rod photoreceptors are known to be more vulnerable than cone photoreceptors.…