生物物理
The cooperative binding of molecular agents onto a substrate is pervasive in living systems. To study whether a system shows cooperativity, one can rely on a fluctuation analysis of quantities such as the number of substrate-bound units and…
Adult spine deformity (ASD) is prevalent and leads to a sagittal misalignment in the vertebral column. Computational methods, including Finite Element (FE) Models, have emerged as valuable tools for investigating the causes and treatment of…
Intrinsically disordered proteins (IDPs) are a subset of proteins that lack stable secondary structure. Given their polymeric nature, previous mean-field approximations have been used to describe the statistical structure of IDPs. However,…
Crowd movements are observed among different species and on different scales, from insects to mammals, as well as in non-cognitive systems, such as motile cells. When forced to escape through a narrow opening, most terrestrial animals…
Water oxidation at the oxygen evolving complex (OEC) of the photosystem II is catalyzed by the core cluster CaMn$_4$O$_5$ which was projected to experience five intermediate states S$\rm_i$ in the Kok's cycle since 1970's. However, the…
The cell nucleus is enveloped by a complex membrane, whose wrinkling has been implicated in disease and cellular aging. The biophysical dynamics and spectral evolution of nuclear wrinkling during multicellular development remain poorly…
A fundamental question of cell biology is how cells control the number of organelles. The processes of organelle biogenesis, namely de novo synthesis, fission, fusion, and decay, are inherently stochastic, producing cell-to-cell variability…
Historically, amyloid fibers (AF) in research has always been linked to degenerative diseases. However, HET-s AF, by their morphology and function, have only little in common to pathogenic amyloid fibers such as {\alpha}-synuclein or…
The endoplasmic reticulum (ER) is a network of sheet-like and tubular structures that spans much of a cell and contains molecules undergoing diffusive searches for targets, such as unfolded proteins searching for chaperones and…
Objectives: Negative splitting (i.e., finishing the race faster) is a tactic commonly employed by elite marathon athletes, even though research supporting the strategy is scarce. The presence of pacers allows the main runner to run behind a…
The electromagnetic Casimir interaction between dielectric objects immersed in salted water includes a universal contribution that is not screened by the solvent and therefore long-ranged. Here, we study the geometry of two parallel…
We introduce a numerical method to extract the parameters of run-and-tumble dynamics from experimental measurements of the intermediate scattering function. We show that proceeding in Laplace space is unpractical and employ instead renewal…
Studies in the collective motility of organisms use a range of analytical approaches to formulate continuous kinetic models of collective dynamics from rules or equations describing agent interactions. However, the derivation of these…
In a recent article [Vetter and Iber, Nat. Commun. 13, 1145 (2022)], we demonstrated that single morphogen gradients in the developing mouse neural tube can carry sufficient positional accuracy to explain the patterning precision of…
In the brain, fine-scale correlations combine to produce macroscopic patterns of activity. However, as experiments record from larger and larger populations, we approach a fundamental bottleneck: the number of correlations one would like to…
The high motility of synaptic weights raises the question of how the brain can retain its functionality in the face of constant synaptic remodeling. Here we used the whisker system of rats and mice to study the interplay between synaptic…
About a hundred years ago the Russian biologist A. Gurwitsch, based on his experiments with onion plants by measuring their growth rate, made the hypothesis that plants emitted a weak electromagnetic field which somehow influenced cell…
The main aim of this study is to report basic knowledge on how a protein corona (PC) could affect or modify the way in which multifunctionalized nanoparticles interact with cells. With this purpose, we have firstly optimized the development…
Conical channels filled with an aqueous electrolyte have been proposed as promising candidates for iontronic neuromorphic circuits. This is facilitated by a novel analytical model for the internal channel dynamics [Kamsma et al.,…
The latest trends in cancer research and nanomedicine focus on using nanocarriers to target cancer stem cells (CSCs). Specifically, lipid liquid nanocapsules are usually developed as nanocarriers for lipophilic drug delivery. Here, we…