生物物理
Finding an odor source in a turbulent flow requires effectively leveraging the history of olfactory observations into a robust navigation strategy. In this work, we use tabular Q-learning to train an olfactory search agent with a minimal…
Biophotonic signaling via axons has been proposed as a potential mode of neural communication, where information might be encoded not only in photon number and wavelength but also in polarization. Although earlier computational studies have…
Accurate quantification of protein-nanoparticle interactions is essential for applications in nanobiotechnology, nanomedicine, and drug delivery. Motivated by recent computational and experimental work, we combine coarse-grained united-atom…
Accurate simulations of electric fields (E-fields) in neural stimulation depend on tissue conductivity representations that link underlying microscopic tissue structure with macroscopic assumptions. Mesoscale conductivity variations can…
Plant sap-feeding insects must dispose of excess fluid, yet at millimeter scales droplet release is constrained by capillary adhesion and contact-line pinning. How phloem-feeding insects solve this puzzle, particularly as the excretory…
Across metazoans, early embryos exhibit a strikingly conserved slowing down of their cell duplication speed, despite widely varying developmental paces and underlying molecular mechanisms. Here we show that this common behavior arises…
Direct numerical simulation of microscale fluid--structure interactions in multicomponent and multiphase flows requires methods that can represent moving boundaries together with fields constrained to evolving interfaces. Diffuse-domain…
Many essential cellular functions depend on the viscoelastic properties of the cytoplasm. While techniques such as optical tweezers and atomic force microscopy can measure these properties, their reliance on localized probes prevents…
High throughput screening was used to study of the biokinetics of F. venenatum A3/5 cultivation on alternative carbon substrates, including monosaccharides, disaccharides and mixtures relevant to food & beverage, dairy and agricultural…
Cellular decision-making based on information received from the external environment is frequently initiated by transmembrane receptors. These receptors are known to propagate such information by triggering a series of irreversible,…
Metabolism unfolds within specific organelles in eukaryotic cells. Lysosomes are highly metabolically active organelles, and their metabolic states dynamically influence signal transduction, cellular homeostasis, and organismal…
Understanding the molecular mechanism by which denaturants modulate protein structure remains a central challenge in protein biophysics. In this work, molecular dynamics simulations were employed to investigate the effects of urea on the…
Multi-nucleated cells exist in all domains of life, ranging from animals, plants and fungi to single-celled organisms such as the slime mold Physarum polycephalum. The large cell size, in the case of Physarum reaching centimeters and more,…
We study the effects of weak magnetic fields (around 2 mT) on the growth of Staphylococcus aureus (S. aureus) in the presence of a few sweeteners (monosaccharides, disaccharides, sugar alcohols, and consumer-grade sweeteners). Bacterial…
Triplet formation and its regulation have always been of central interest in understanding the photophysical behavior of living systems. In organic systems, excessive triplet formation poses significant challenges, as it can promote…
Glassy carbon (GC) microelectrodes are increasingly being used for voltametric detection of electroactive neurotransmitters such as dopamine and serotonin. However, non-electroactive molecules including lactate, glutamate, and…
This e-letter re-evaluates the epidemiological impact of nationwide mass antigen testing in Slovakia. While initial reports \cite{Pavelka} proposed a causal link between these campaigns and declining viral prevalence, granular re-analysis…
Biological cells are able to adapt their behaviour in response to environmental cues. Durotaxis is a phenomenon in which cells adjust their migration depending on the mechanical properties of a surrounding substrate. Although durotaxis has…
A major unresolved question in Neuroscience is: What is the origin of the observed scale-invariant correlations in neural activity? Many researchers support the ``criticality hypothesis,'' which proposes that the brain operates near…
Contradictory experimental reports on the relationship between efficiency and stimulation frequency have hindered mechanistic understanding in converting neural activity into mechanical work during muscle contraction. To resolve this issue,…