生物物理
Cochlea displays complex and highly nonlinear behavior in response to wide-ranging auditory stimuli. While there have been many recent advancements in the modeling of cochlear dynamics, it remains unclear what mathematical structures…
Recent experiments suggest that the interplay between cells and the mechanics of their substrate gives rise to a diversity of morphological and migrational behaviors. Here, we develop a Cellular Potts Model of polarizing cells on a…
Recently, some authors have shown that a DNA molecule produces electromagnetic signals and communicates with other DNA molecules or other molecules. In fact, a DNA acts like a receiver or transmitter of radio waves. In this paper, we…
Since the pioneering works of the founder of membrane mimetic chemistry Janos H. Fendler it is known that a number of atomic or molecular clusters and films (including nanoscale ones) are capable of mimicking the membrane functions.…
This work describes an experiment and some results from instability involving the proliferation achieved by cells over some radio frequency electromagnetic field. Saccharomyces cerevisiae cells were cultured, and separate samples were…
The collective motion of membrane lipids over hundred of nanometers and nanoseconds is essential for the formation of submicron complexes of lipids and proteins in the cell membrane. These dynamics are difficult to access experimentally and…
Here the term "high frequency" refers to daily, weekly or monthly birth data. The fluctuations of daily birth numbers show a succession of spikes and dips which, at least at first sight, looks almost as random as white noise. However in…
Allosteric proteins transmit a mechanical signal induced by binding a ligand. However, understanding the nature of the information transmitted and the architectures optimizing such transmission remains a challenge. Here we show using an…
Measurement of the life time of attachments formed by a single microtubule (MT) with a single kinetochore (kt) {\it in-vitro} under force-clamp conditions had earlier revealed a catch-bond-like behavior. In the past the physical origin of…
Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival. The dynamics and interactions of cytoskeletal components control…
In order to give insights into how anisotropic nano-objects interact with living cell membranes, and possibly self-assemble, we designed magnetic nanorods with average size around 100 nm x 1$\mu$m by assembling iron oxide nanocubes within a…
The totally asymmetric simple exclusion process (TASEP) is a paradigmatic stochastic model for non-equilibrium physics, and has been successfully applied to describe active transport of molecular motors along cytoskeletal filaments.…
Measuring and quantifying non-equilibrium dynamics in active biological systems is a major challenge, because of their intrinsic stochastic nature and the limited number of variables accessible in any real experiment. We investigate what…
We use optical trapping to continuously bend an isolated microtubule while simultaneously measuring the applied force and the resulting filament strain, thus allowing us to determine its elastic properties over a wide range of applied…
The spreading of bacterial colonies at solid-air interfaces is determined by the physico-chemical properties of the involved interfaces. The production of surfactant molecules by bacteria is a widespread strategy that allows the colony to…
The propagation of an action potential (AP) in a nerve fibre is accompanied by mechanical and thermal effects. In this paper an attempt is made to build up a mathematical model which couples the AP with a possible pressure wave (PW) in the…
Physics-based modeling and dynamic simulation of human eye movements has significant implications for improving our understanding of the oculomotor system and treating various visuomotor disorders. We introduce an open-source biomechanical…
In agreement with previous findings (Nissen 2017a,b), data (Wilczek-Vera et al. 2004) for the ion activities of a variety of simple inorganic compounds are shown to be precisely represented as multiphasic, i.e. as a series of straight lines…
We investigate the nonlinear dynamics of the Peyrard-Bishop DNA model taking into account site dependent inhomogeneities. By means of the multiple-scale expansion in the semi-discrete approximation, the dynamics is governed by the perturbed…
The migration of cells through tight constricting spaces or along fibrous tracks in tissues is important for biological processes, such as embryogenesis, wound healing, and cancer metastasis, and depends on the mechanical properties of the…