Optimal Path to Epigenetic Switching
分子网络
2013-05-29 v3 细胞行为
摘要
We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.
引用
@article{arxiv.q-bio/0406008,
title = {Optimal Path to Epigenetic Switching},
author = {David Marin Roma and Ruadhan A. O'Flanagan and Andrei E. Ruckenstein and Anirvan M. Sengupta and Ranjan Mukhopadhyay},
journal= {arXiv preprint arXiv:q-bio/0406008},
year = {2013}
}
备注
5 pages. 2 figures, uses revtex 4. PR-E reviewed for publication