大型细胞图谱提供的见解、机遇与挑战
基因组学
2024-08-14 v1
摘要
单细胞生物学领域正在迅速发展，并来自各种物种、疾病状况、组织和器官的大量数据。协调努力如CZI CELLxGENE、HuBMAP、Broad Institute Single Cell Portal和DISCO，使研究人员能够访问大量经过整理的数据集。尽管大多数数据来自scRNAseq实验，但也代表了广泛的其他模态。这些资源创造了构建和扩展计算生物学生态系统的机会，以开发数据重用所需的必要工具，以及提取新的生物学见解。在这里，我们强调了迄今为止取得的成就、需要进一步发展的领域以及需要克服的具体挑战。
引用
@article{arxiv.2408.06563,
title = {Insights, opportunities and challenges provided by large cell atlases},
author = {Martin Hemberg and Federico Marini and Shila Ghazanfar and Ahmad Al Ajami and Najla Abassi and Benedict Anchang and Bérénice A. Benayoun and Yue Cao and Ken Chen and Yesid Cuesta-Astroz and Zach DeBruine and Calliope A. Dendrou and Iwijn De Vlaminck and Katharina Imkeller and Ilya Korsunsky and Alex R. Lederer and Pieter Meysman and Clint Miller and Kerry Mullan and Uwe Ohler and Nikolaos Patikas and Jonas Schuck and Jacqueline HY Siu and Timothy J. Triche and Alex Tsankov and Sander W. van der Laan and Masanao Yajima and Jean Yang and Fabio Zanini and Ivana Jelic},
journal= {arXiv preprint arXiv:2408.06563},
year = {2024}
}