Current and future directions in network biology
Abstract
Network biology is an interdisciplinary field bridging computational and biological sciences that has proved pivotal in advancing the understanding of cellular functions and diseases across biological systems and scales. Although the field has been around for two decades, it remains nascent. It has witnessed rapid evolution, accompanied by emerging challenges. These challenges stem from various factors, notably the growing complexity and volume of data together with the increased diversity of data types describing different tiers of biological organization. We discuss prevailing research directions in network biology and highlight areas of inference and comparison of biological networks, multimodal data integration and heterogeneous networks, higher-order network analysis, machine learning on networks, and network-based personalized medicine. Following the overview of recent breakthroughs across these five areas, we offer a perspective on the future directions of network biology. Additionally, we offer insights into scientific communities, educational initiatives, and the importance of fostering diversity within the field. This paper establishes a roadmap for an immediate and long-term vision for network biology.
Cite
@article{arxiv.2309.08478,
title = {Current and future directions in network biology},
author = {Marinka Zitnik and Michelle M. Li and Aydin Wells and Kimberly Glass and Deisy Morselli Gysi and Arjun Krishnan and T. M. Murali and Predrag Radivojac and Sushmita Roy and Anaïs Baudot and Serdar Bozdag and Danny Z. Chen and Lenore Cowen and Kapil Devkota and Anthony Gitter and Sara Gosline and Pengfei Gu and Pietro H. Guzzi and Heng Huang and Meng Jiang and Ziynet Nesibe Kesimoglu and Mehmet Koyuturk and Jian Ma and Alexander R. Pico and Nataša Pržulj and Teresa M. Przytycka and Benjamin J. Raphael and Anna Ritz and Roded Sharan and Yang Shen and Mona Singh and Donna K. Slonim and Hanghang Tong and Xinan Holly Yang and Byung-Jun Yoon and Haiyuan Yu and Tijana Milenković},
journal= {arXiv preprint arXiv:2309.08478},
year = {2024}
}
Comments
52 pages, 6 figures, 1 table