Casimir Effect confronts Cosmological Constant

It has been speculated that the zero-point energy of the vacuum, regularized due to the existence of a suitable ultraviolet cut-off scale, could be the source of the non-vanishing cosmological constant that is driving the present acceleration of the universe. We show that the presence of such a cut-off can significantly alter the results for the Casimir force between parallel conducting plates and even lead to repulsive Casimir force when the plate separation is smaller than the cut-off scale length. Using the current experimental data we rule out the possibility that the observed cosmological constant arises from the zero-point energy which is made finite by a suitable cut-off. Any such cut-off which is consistent with the observed Casimir effect will lead to an energy density which is about 10^{12} times larger than the observed one, if gravity couples to these modes. The implications are discussed.