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Multi-agent deliberation systems using large language models (LLMs) are increasingly proposed for policy simulation, yet they suffer from artificial consensus: evaluator agents converge on the same option regardless of their assigned value…

Multiagent Systems · Computer Science 2026-04-30 Ariel Sela

Computational drug repurposing for rare diseases is especially challenging when no prior associations exist between drugs and target diseases. Therefore, knowledge graph completion and message-passing GNNs have little reliable signal to…

Artificial Intelligence · Computer Science 2025-10-17 Lang Qin , Zijian Gan , Xu Cao , Pengcheng Jiang , Yankai Jiang , Jiawei Han , Kaishun Wu , Jintai Chen

Large language models applied to clinical prediction exhibit case-level heterogeneity: simple cases yield consistent outputs, while complex cases produce divergent predictions under minor prompt changes. Existing single-agent strategies…

Artificial Intelligence · Computer Science 2026-04-02 Yuxing Lu , Yushuhong Lin , Jason Zhang

While individual components of agentic architectures have been studied in isolation, there remains limited empirical understanding of how different design dimensions interact within complex multi-agent systems. This study aims to address…

Artificial Intelligence · Computer Science 2026-01-07 Tara Bogavelli , Roshnee Sharma , Hari Subramani

Inpatient pathways demand complex clinical decision-making based on comprehensive patient information, posing critical challenges for clinicians. Despite advancements in large language models (LLMs) in medical applications, limited research…

Artificial Intelligence · Computer Science 2025-03-18 Zhen Chen , Zhihao Peng , Xusheng Liang , Cheng Wang , Peigan Liang , Linsheng Zeng , Minjie Ju , Yixuan Yuan

Integrating Large Language Models (LLMs) in healthcare diagnosis demands systematic frameworks that can handle complex medical scenarios while maintaining specialized expertise. We present KG4Diagnosis, a novel hierarchical multi-agent…

Artificial Intelligence · Computer Science 2025-04-01 Kaiwen Zuo , Yirui Jiang , Fan Mo , Pietro Lio

Large language models are increasingly being assembled into medical multi-agent systems that emulate multidisciplinary consultation through specialist roles, peer review and consensus formation. In clinical decision support, however,…

Computation and Language · Computer Science 2026-05-28 Yinghao Zhu , Lei Gu , Zixiang Wang , Haoran Sang , Dehao Sui , Wen Tang , Lan Mi , Yasha Wang , Junyi Gao , Liang Yao , Tianfan Fu , Ewen Harrison , Lequan Yu , Liantao Ma

Large Language Models (LLMs) exhibit high reasoning capacity in medical question-answering, but their tendency to produce hallucinations and outdated knowledge poses critical risks in healthcare fields. While Retrieval-Augmented Generation…

Computation and Language · Computer Science 2026-03-25 Wenhao Wu , Zhentao Tang , Yafu Li , Shixiong Kai , Mingxuan Yuan , Chunlin Chen , Zhi Wang

Therapeutic decision-making in clinical medicine constitutes a high-stakes domain in which AI guidance interacts with complex interactions among patient characteristics, disease processes, and pharmacological agents. Tasks such as drug…

Artificial Intelligence · Computer Science 2025-12-15 Tim Cofala , Christian Kalfar , Jingge Xiao , Johanna Schrader , Michelle Tang , Wolfgang Nejdl

Evaluating large language models (LLM) in clinical scenarios is crucial to assessing their potential clinical utility. Existing benchmarks rely heavily on static question-answering, which does not accurately depict the complex, sequential…

Human-Computer Interaction · Computer Science 2025-05-27 Samuel Schmidgall , Rojin Ziaei , Carl Harris , Eduardo Reis , Jeffrey Jopling , Michael Moor

Large Language Models (LLMs) have shown remarkable reasoning capabilities in mathematical and scientific tasks. To enhance complex reasoning, multi-agent systems have been proposed to harness the collective intelligence of LLM agents.…

Artificial Intelligence · Computer Science 2025-10-22 Zhenyu Bi , Meng Lu , Yang Li , Swastik Roy , Weijie Guan , Morteza Ziyadi , Xuan Wang

Large language models (LLMs) increasingly operate as autonomous agents that reason over external APIs to perform complex tasks. However, their reliability and agreement remain poorly characterized. We present a unified benchmarking…

Information Retrieval · Computer Science 2026-04-28 Eyhab Al-Masri

Large Language Models (LLMs) have enabled collaborative Multi-Agent (MA) systems, where interacting agents improve performance through diverse reasoning and iterative refinement. However, these systems remain vulnerable to error…

Multiagent Systems · Computer Science 2026-05-21 Yong Jin Chun , Iftekhar Ahmed

Multi-agent systems have demonstrated exceptional performance in downstream tasks beyond diverse single agent baselines. A growing body of work has explored ways to improve their reasoning and collaboration, from vote, debate, to complex…

Artificial Intelligence · Computer Science 2026-02-13 Yu Yao , Jiayi Dong , Yang Yang , Ju Li , Yilun Du

Most reported gains on agentic-LLM clinical benchmarks are often attributed to prompt engineering, yet our results suggest that larger improvements can come from architectural and engine-level design. We present MDIA, a Multi-agent…

Artificial Intelligence · Computer Science 2026-05-26 Roberto Cruz , David Rey-Blanco

PET theranostics is transforming precision oncology, yet treatment response varies substantially; many patients receiving 177Lu-PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) fail to respond,…

Multimodal artificial intelligence (AI) systems have the potential to enhance clinical decision-making by interpreting various types of medical data. However, the effectiveness of these models across all medical fields is uncertain. Each…

Topology optimization is a widely used design method that produces optimized material distributions for prescribed objectives and constraints through well-established numerical algorithms. Throughout the workflow, engineers make a series of…

Multiagent Systems · Computer Science 2026-05-25 Hyunjee Park , Hayoung Chung

To improve the reasoning and question-answering capabilities of Large Language Models (LLMs), several multi-agent approaches have been introduced. While these methods enhance performance, the application of collective intelligence-based…

Artificial Intelligence · Computer Science 2024-07-10 Ciaran Regan , Alexandre Gournail , Mizuki Oka

Entity relationship classification remains a challenging task in information extraction, especially in scenarios with limited labeled data and complex relational structures. In this study, we conduct a comparative analysis of three distinct…

Computation and Language · Computer Science 2026-03-24 Maryam Berijanian , Kuldeep Singh , Amin Sehati