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In healthcare, multi-organ system diseases pose unique and significant challenges as they impact multiple physiological systems concurrently, demanding complex and coordinated treatment strategies. Despite recent advancements in the AI…

Artificial Intelligence · Computer Science 2025-08-08 Daniel J. Tan , Qianyi Xu , Kay Choong See , Dilruk Perera , Mengling Feng

Therapy recommendation for chronic patients with multimorbidity is challenging due to risks of treatment conflicts. Existing decision support systems face scalability limitations. Inspired by the way in which general practitioners (GP)…

Artificial Intelligence · Computer Science 2025-07-16 Yicong Wu , Ting Chen , Irit Hochberg , Zhoujian Sun , Ruth Edry , Zhengxing Huang , Mor Peleg

Agentic memory systems enable large language model (LLM) agents to maintain state across long interactions, supporting long-horizon reasoning and personalization beyond fixed context windows. Despite rapid architectural development, the…

Computation and Language · Computer Science 2026-05-21 Dongming Jiang , Yi Li , Songtao Wei , Jinxin Yang , Ayushi Kishore , Alysa Zhao , Dingyi Kang , Xu Hu , Feng Chen , Qiannan Li , Bingzhe Li

Multi-agent systems extend large language models (LLMs) by decomposing tasks among specialized agents, but their distributed decision process creates new attack surfaces. We identify semantic hijacking, an attack in which harmful requests…

Artificial Intelligence · Computer Science 2026-05-20 Qiqi Liu , Thorsten Holz , Shilin Ye , Runhan Song

Background: Cognitive biases in clinical decision-making significantly contribute to errors in diagnosis and suboptimal patient outcomes. Addressing these biases presents a formidable challenge in the medical field. Objective: This study…

Computation and Language · Computer Science 2024-05-14 Yu He Ke , Rui Yang , Sui An Lie , Taylor Xin Yi Lim , Hairil Rizal Abdullah , Daniel Shu Wei Ting , Nan Liu

Motivated by the challenge to improve the adversarial robustness, security, and trust of medical decision making intelligent agents, this study develops a full-link security enhancement framework, which describes "input risk perception -…

Cryptography and Security · Computer Science 2026-05-12 Saisai Hu

Multi-agent systems (MAS) have emerged as a prominent paradigm for leveraging large language models (LLMs) to tackle complex tasks. However, the mechanisms governing the effectiveness of MAS built upon publicly available LLMs, specifically…

Multiagent Systems · Computer Science 2026-05-11 Yuxuan Zhao , Sijia Chen , Ningxin Su

Large language model(LLM)-driven multi-agent systems(MAS) coordinate specialized agents through predefined interaction topologies and have shown promise for complex tasks such as competition-level code generation. Recent studies demonstrate…

Multiagent Systems · Computer Science 2026-02-20 Siyu Wang , Ruotian Lu , Zhihao Yang , Yuchao Wang , Yanzhou Zhang , Lei Xu , Qimin Xu , Guojun Yin , Cailian Chen , Xinping Guan

Recent work reports strong performance from multi-agent LLM systems (MAS), but these gains are often confounded by increased test-time computation. When computation is normalized, single-agent systems (SAS) can match or outperform MAS, yet…

Computation and Language · Computer Science 2026-04-14 Dat Tran , Douwe Kiela

Agentic security systems increasingly audit live targets with tool-using LLMs, but prior systems fix a single coordination topology, leaving unclear when additional agents help and when they only add cost. We treat topology choice as an…

Cryptography and Security · Computer Science 2026-04-22 Isaac David , Arthur Gervais

Existing frameworks for LLM-based agent architectures describe systems from a single perspective: industry guides (Anthropic, Google, LangChain) focus on execution topology -- how data flows -- while cognitive science surveys focus on…

Artificial Intelligence · Computer Science 2026-05-26 Jia Huang , Joey Tianyi Zhou

In an era where single large language models have dominated the landscape of artificial intelligence for years, multi-agent systems arise as new protagonists in conversational task-solving. While previous studies have showcased their…

Computation and Language · Computer Science 2024-11-04 Jonas Becker

Large-language models (LLMs) have demonstrated powerful problem-solving capabilities, in particular when organized in multi-agent systems. However, the advent of such systems also raises several questions on the ability of a complex network…

Multiagent Systems · Computer Science 2025-07-14 Florian Grötschla , Luis Müller , Jan Tönshoff , Mikhail Galkin , Bryan Perozzi

Large Language Models (LLMs) have demonstrated strong capabilities as autonomous agents through tool use, planning, and decision-making abilities, leading to their widespread adoption across diverse tasks. As task complexity grows,…

Multiagent Systems · Computer Science 2025-11-10 Ishan Kavathekar , Hemang Jain , Ameya Rathod , Ponnurangam Kumaraguru , Tanuja Ganu

Multi-agent systems (MAS) built on large language models promise improved problem-solving through collaboration, yet they often fail to consistently outperform strong single-agent baselines due to error propagation at inter-agent message…

Artificial Intelligence · Computer Science 2026-01-21 Bohan Lin , Kuo Yang , Zelin Tan , Yingchuan Lai , Chen Zhang , Guibin Zhang , Xinlei Yu , Miao Yu , Xu Wang , Yudong Zhang , Yang Wang

Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic…

Artificial Intelligence · Computer Science 2025-10-14 Hongjie Zheng , Zesheng Shi , Ping Yi

Large Language Model (LLM)-based multi-agent systems are increasingly applied to automate computational workflows in science and engineering. However, how inter-agent dynamics influence reasoning quality and verification reliability remains…

Artificial Intelligence · Computer Science 2025-11-07 Chuan Tian , Yilei Zhang

Designing effective collaboration structure for multi-agent LLM systems to enhance collective reasoning is crucial yet remains under-explored. In this paper, we systematically investigate how collaborative reasoning performance is affected…

Computation and Language · Computer Science 2025-05-19 Baixuan Xu , Chunyang Li , Weiqi Wang , Wei Fan , Tianshi Zheng , Haochen Shi , Tao Fan , Yangqiu Song , Qiang Yang

The integration of Large Language Models (LLMs) into healthcare is constrained by knowledge limitations, hallucinations, and a disconnect from Evidence-Based Medicine (EBM). While Retrieval-Augmented Generation (RAG) offers a solution,…

Computation and Language · Computer Science 2026-02-03 Qiaoyu Zheng , Yuze Sun , Chaoyi Wu , Weike Zhao , Pengcheng Qiu , Yongguo Yu , Kun Sun , Jian Zhang , Yanfeng Wang , Ya Zhang , Weidi Xie

Large-scale telecom and datacenter infrastructures rely on multi-layered service and resource models, where failures propagate across physical and logical components and affect multiple customers. Traditional approaches to root cause…

Artificial Intelligence · Computer Science 2026-01-13 Nicolas Tacheny