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As AI agents evolve, the community is rapidly shifting from single Large Language Models (LLMs) to Multi-Agent Systems (MAS) to overcome cognitive bottlenecks in automated research. However, the optimal multi-agent coordination framework…

Multiagent Systems · Computer Science 2026-05-12 Yang Shen , Zhenyi Yi , Ziyi Zhao , Lijun Sun , Dongyang Li , Chin-Teng Lin , Yuhui Shi

When LLM agents work together, they seem to be more powerful than a single LLM in mathematical question answering. However, are they also more robust to adversarial inputs? We investigate this question using adversarially perturbed math…

Computation and Language · Computer Science 2026-03-17 Khashayar Alavi , Zhastay Yeltay , Lucie Flek , Akbar Karimi

Large language models (LLMs) deployed as agents introduce significant safety risks in clinical settings due to their potential for error and single points of failure. We introduce Tiered Agentic Oversight (TAO), a hierarchical multi-agent…

Accurate interpretation of clinical narratives is critical for patient care, but the complexity of these notes makes automation challenging. While Large Language Models (LLMs) show promise, single-model approaches can lack the robustness…

Artificial Intelligence · Computer Science 2025-09-01 Yeawon Lee , Xiaoyang Wang , Christopher C. Yang

Large Language Models (LLMs) and multi-agent systems have shown impressive capabilities in natural language tasks but face challenges in clinical trial applications, primarily due to limited access to external knowledge. Recognizing the…

Computation and Language · Computer Science 2024-07-23 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu

Background: Globally we face a projected shortage of 11 million healthcare practitioners by 2030, and administrative burden consumes 50% of clinical time. Artificial intelligence (AI) has the potential to help alleviate these problems.…

Human-Computer Interaction · Computer Science 2025-08-01 Hashim Hayat , Maksim Kudrautsau , Evgeniy Makarov , Vlad Melnichenko , Tim Tsykunou , Piotr Varaksin , Matt Pavelle , Adam Z. Oskowitz

Unlike most primary headaches, secondary headaches need specialized care and can have devastating consequences if not treated promptly. Clinical guidelines highlight several 'red flag' features, such as thunderclap onset, meningismus,…

Rare diseases represent the long tail of medical imaging, where AI models often fail due to the scarcity of representative training data. In clinical workflows, radiologists frequently consult case reports and literature when confronted…

Computation and Language · Computer Science 2025-11-10 Ha Young Kim , Jun Li , Ana Beatriz Solana , Carolin M. Pirkl , Benedikt Wiestler , Julia A. Schnabel , Cosmin I. Bercea

Dermatological care via telemedicine often lacks the rich context of in-person visits. Clinicians must make diagnoses based on a handful of images and brief descriptions, without the benefit of physical exams, second opinions, or reference…

Artificial Intelligence · Computer Science 2025-08-27 Karishma Thakrar , Shreyas Basavatia , Akshay Daftardar

Advancements in large language models (LLMs) allow them to address diverse questions using human-like interfaces. Still, limitations in their training prevent them from answering accurately in scenarios that could benefit from multiple…

Artificial Intelligence · Computer Science 2025-04-09 Yoshitaka Inoue , Tianci Song , Xinling Wang , Augustin Luna , Tianfan Fu

This paper presents an innovative large language model (LLM) agent framework for enhancing diagnostic accuracy in simulated clinical environments using the AgentClinic benchmark. The proposed automatic correction enables doctor agents to…

Artificial Intelligence · Computer Science 2024-10-15 Abhishek Dutta , Yen-Che Hsiao

Large language model (LLM)-based agents are increasingly used to perform complex, multi-step workflows in regulated settings such as compliance and due diligence. However, many agentic architectures rely primarily on prompt engineering of a…

Artificial Intelligence · Computer Science 2026-02-03 Ananya Joshi , Michael Rudow

As large language models from diverse providers converge toward comparable benchmark performance, the traditional paradigm of selecting a single best model per task yields diminishing returns. We argue that orchestration topology -- the…

Multiagent Systems · Computer Science 2026-02-20 Geunbin Yu

Large language models (LLMs) are increasingly used in clinical settings, raising concerns about racial bias in both generated medical text and clinical reasoning. Existing studies have identified bias in medical LLMs, but many focus on…

Computers and Society · Computer Science 2026-04-21 Sihao Xing , Zaur Gouliev

Deploying compound LLM agents in adversarial, partially observable sequential environments requires navigating several design dimensions: (1) what the agent sees, (2) how it reasons, and (3) how tasks are decomposed across components. Yet…

Artificial Intelligence · Computer Science 2026-05-18 Igor Bogdanov , Chung-Horng Lung , Thomas Kunz , Jie Gao , Adrian Taylor , Marzia Zaman

How much autonomy can multi-agent LLM systems sustain -- and what enables it? We present a 25,000-task computational experiment spanning 8 models, 4--256 agents, and 8 coordination protocols ranging from externally imposed hierarchy to…

Artificial Intelligence · Computer Science 2026-04-01 Victoria Dochkina

The integration of large language models (LLMs) into healthcare IoT systems promises faster decisions and improved medical support. LLMs are also deployed as multi-agent teams to assist AI doctors by debating, voting, or advising on…

Cryptography and Security · Computer Science 2025-12-04 Adeela Bashir , The Anh han , Zia Ush Shamszaman

Multi-modal multi-agent systems (MM-MAS) have gained increasing attention for their capacity to enable complex reasoning and coordination across diverse modalities. As these systems continue to expand in scale and functionality,…

Artificial Intelligence · Computer Science 2026-05-15 Hao Zhou , Tiru Wu , Yan Jiang , Wanqi Zhou , Junxing Hu , Ai Han

Large Language Models (LLMs) are becoming increasingly powerful and capable of handling complex tasks, e.g., building single agents and multi-agent systems. Compared to single agents, multi-agent systems have higher requirements for the…

Computation and Language · Computer Science 2024-08-29 Wei Wang , Dan Zhang , Tao Feng , Boyan Wang , Jie Tang

Recently, the field of Multi-Agent Systems (MAS) has gained popularity as researchers are trying to develop artificial intelligence capable of efficient collective reasoning. Agents based on Large Language Models (LLMs) perform well in…

Multiagent Systems · Computer Science 2025-07-30 Adam Kostka , Jarosław A. Chudziak