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This paper presents the first attempt to learn semantic boundary detection using image-level class labels as supervision. Our method starts by estimating coarse areas of object classes through attentions drawn by an image classification…

Multiple Instance Learning (MIL) has been widely used in weakly supervised whole slide image (WSI) classification. Typical MIL methods include a feature embedding part, which embeds the instances into features via a pre-trained feature…

In this paper, we address the challenge of few-shot classification in histopathology whole slide images (WSIs) by utilizing foundational vision-language models (VLMs) and slide-level prompt learning. Given the gigapixel scale of WSIs,…

The whole slide image (WSI) classification is often formulated as a multiple instance learning (MIL) problem. Since the positive tissue is only a small fraction of the gigapixel WSI, existing MIL methods intuitively focus on identifying…

Whole-slide images (WSIs) contain tissue information distributed across multiple magnification levels, yet most self-supervised methods treat these scales as independent views. This separation prevents models from learning representations…

In pre-clinical pathology, there is a paradox between the abundance of raw data (whole slide images from many organs of many individual animals) and the lack of pixel-level slide annotations done by pathologists. Due to time constraints and…

Segmentation of objects of interest is one of the central tasks in medical image analysis, which is indispensable for quantitative analysis. When developing machine-learning based methods for automated segmentation, manual annotations are…

Multiple Instance Learning (MIL) has demonstrated promise in Whole Slide Image (WSI) classification. However, a major challenge persists due to the high computational cost associated with processing these gigapixel images. Existing methods…

Multiple instance learning (MIL) has become a preferred method for gigapixel whole slide image (WSI) classification without requiring patch-level annotations. Current MIL research primarily relies on embedding-based approaches, which…

Histopathology slides are routinely marked by pathologists using permanent ink markers that should not be removed as they form part of the medical record. Often tumour regions are marked up for the purpose of highlighting features or other…

In whole slide images (WSIs) analysis, attention-based multi-instance learning (MIL) models are susceptible to spurious correlations and degrade under domain shift. These methods may assign high attention weights to non-tumor regions, such…

The necessity of large amounts of labeled data to train deep models, especially in medical imaging creates an implementation bottleneck in resource-constrained settings. In Insite (labelINg medical imageS usIng submodular funcTions and…

Current methods for developing foundation models in medical image segmentation rely on two primary assumptions: a fixed set of classes and the immediate availability of a substantial and diverse training dataset. However, this can be…

Two problems often plague medical imaging analysis: 1) Non-availability of large quantities of labeled training data, and 2) Dealing with imbalanced data, i.e., abundant data are available for frequent classes, whereas data are highly…

Introducing interpretability and reasoning into Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) analysis is challenging, given the complexity of gigapixel slides. Traditionally, MIL interpretability is limited to…

Large scale object detection with thousands of classes introduces the problem of many contradicting false positive detections, which have to be suppressed. Class-independent non-maximum suppression has traditionally been used for this step,…

Deep learning has shown strong potential in cancer classification from whole-slide images (WSIs), but the need for extensive expert annotations often limits its success. Annotation-free approaches, such as multiple instance learning (MIL)…

When approaching the semantic segmentation of overhead imagery in the decimeter spatial resolution range, successful strategies usually combine powerful methods to learn the visual appearance of the semantic classes (e.g. convolutional…

Multiple Instance Learning (MIL) has become the predominant approach for classification tasks on gigapixel histopathology whole slide images (WSIs). Within the MIL framework, single WSIs (bags) are decomposed into patches (instances), with…

Behavioral changes are the earliest signs of a mental disorder, but arguably, the dynamics of brain function gets affected even earlier. Subsequently, spatio-temporal structure of disorder-specific dynamics is crucial for early diagnosis…