Whole-slide images (WSIs) contain tissue information distributed across multiple magnification levels, yet most self-supervised methods treat these scales as independent views. This separation prevents models from learning representations that remain stable when resolution changes, a key requirement for practical neuropathology workflows. This study introduces Magnification-Aware Distillation (MAD), a self-supervised strategy that links low-magnification context with spatially aligned high-magnification detail, enabling the model to learn how coarse tissue structure relates to fine cellular patterns. The resulting foundation model, MAD-NP, is trained entirely through this cross-scale correspondence without annotations. A linear classifier trained only on 10x embeddings maintains 96.7% of its performance when applied to unseen 40x tiles, demonstrating strong resolution-invariant representation learning. Segmentation outputs remain consistent across magnifications, preserving anatomical boundaries and minimizing noise. These results highlight the feasibility of scalable, magnification-robust WSI analysis using a unified embedding space
@article{arxiv.2512.14796,
title = {Magnification-Aware Distillation (MAD): A Self-Supervised Framework for Unified Representation Learning in Gigapixel Whole-Slide Images},
author = {Mahmut S. Gokmen and Mitchell A. Klusty and Peter T. Nelson and Allison M. Neltner and Sen-Ching Samson Cheung and Thomas M. Pearce and David A Gutman and Brittany N. Dugger and Devavrat S. Bisht and Margaret E. Flanagan and V. K. Cody Bumgardner},
journal= {arXiv preprint arXiv:2512.14796},
year = {2025}
}