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Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). However, existing approaches typically rely on pre-trained models from large natural image datasets, such as…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Yi Lin , Zhongchen Zhao , Zhengjie ZHU , Lisheng Wang , Kwang-Ting Cheng , Hao Chen

Whole slide images (WSIs) pose fundamental computational challenges due to their gigapixel resolution and the sparse distribution of informative regions. Existing approaches often treat image patches independently or reshape them in ways…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Weiyi Wu , Xingjian Diao , Chunhui Zhang , Chongyang Gao , Xinwen Xu , Siting Li , Jiang Gui

This work addresses how to efficiently classify challenging histopathology images, such as gigapixel whole-slide images for cancer diagnostics with image-level annotation. We use images with annotated tumor regions to identify a set of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Mohammad Iqbal Nouyed , Mary-Anne Hartley , Gianfranco Doretto , Donald A. Adjeroh

Traditional supervised medical image segmentation models require large amounts of labeled data for training; however, obtaining such large-scale labeled datasets in the real world is extremely challenging. Recent semi-supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Yunyao Lu , Yihang Wu , Reem Kateb , Ahmad Chaddad

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). Existing approaches typically rely on frozen pre-trained models to extract instance features, neglecting the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-20 Yi Lin , Zhengjie Zhu , Kwang-Ting Cheng , Hao Chen

Semi-supervised medical image segmentation (SSMIS) seeks to match fully supervised performance while sharply reducing annotation cost. Mainstream SSMIS methods rely on \emph{label-space consistency}, yet they overlook the equally critical…

Computer Vision and Pattern Recognition · Computer Science 2026-01-15 Shujian Gao , Yuan Wang , Zekuan Yu

The task of large-scale retrieval-based image localization is to estimate the geographical location of a query image by recognizing its nearest reference images from a city-scale dataset. However, the general public benchmarks only provide…

Computer Vision and Pattern Recognition · Computer Science 2020-07-10 Yixiao Ge , Haibo Wang , Feng Zhu , Rui Zhao , Hongsheng Li

For classifying digital whole slide images in the absence of pixel level annotation, typically multiple instance learning methods are applied. Due to the generic applicability, such methods are currently of very high interest in the…

Segmentation is one of the most important tasks in the medical imaging pipeline as it influences a number of image-based decisions. To be effective, fully supervised segmentation approaches require large amounts of manually annotated…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Tyler Ward , Aaron Moseley , Abdullah-Al-Zubaer Imran

Multi-modal medical image segmentation plays an essential role in clinical diagnosis. It remains challenging as the input modalities are often not well-aligned spatially. Existing learning-based methods mainly consider sharing trainable…

Computer Vision and Pattern Recognition · Computer Science 2021-01-06 Jingkun Chen , Wenqi Li , Hongwei Li , Jianguo Zhang

Trained using only image class label, deep weakly supervised methods allow image classification and ROI segmentation for interpretability. Despite their success on natural images, they face several challenges over histology data where ROI…

Image and Video Processing · Electrical Eng. & Systems 2022-05-13 Soufiane Belharbi , Jérôme Rony , Jose Dolz , Ismail Ben Ayed , Luke McCaffrey , Eric Granger

Medical imaging has witnessed remarkable progress but usually requires a large amount of high-quality annotated data which is time-consuming and costly to obtain. To alleviate this burden, semi-supervised learning has garnered attention as…

Computer Vision and Pattern Recognition · Computer Science 2023-07-24 Qingyue Wei , Lequan Yu , Xianhang Li , Wei Shao , Cihang Xie , Lei Xing , Yuyin Zhou

Recent advancements in foundation models, typically trained with self-supervised learning on large-scale and diverse datasets, have shown great potential in medical image analysis. However, due to the significant spatial heterogeneity of…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Lingxiao Luo , Xuanzhong Chen , Bingda Tang , Xinsheng Chen , Rong Han , Chengpeng Hu , Yujiang Li , Ting Chen

The scarcity of pixel-level annotation is a prevalent problem in medical image segmentation tasks. In this paper, we introduce a novel regularization strategy involving interpolation-based mixing for semi-supervised medical image…

Image and Video Processing · Electrical Eng. & Systems 2022-02-04 Hritam Basak , Rajarshi Bhattacharya , Rukhshanda Hussain , Agniv Chatterjee

Consistency regularization on label predictions becomes a fundamental technique in semi-supervised learning, but it still requires a large number of training iterations for high performance. In this study, we analyze that the consistency…

Machine Learning · Computer Science 2022-06-10 Doyup Lee , Sungwoong Kim , Ildoo Kim , Yeongjae Cheon , Minsu Cho , Wook-Shin Han

Multiple instance learning (MIL) is a promising approach for weakly supervised classification in pathology using whole slide images (WSIs). However, conventional MIL methods such as Attention-Based Deep Multiple Instance Learning (ABMIL)…

Image and Video Processing · Electrical Eng. & Systems 2025-04-28 Hassan Keshvarikhojasteh , Mihail Tifrea , Sibylle Hess , Josien P. W. Pluim , Mitko Veta

Deep neural networks are increasingly applied in automated histopathology. Yet, whole-slide images (WSIs) are often acquired at gigapixel sizes, rendering them computationally infeasible to analyze entirely at high resolution. Diagnostic…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Tarun G , Naman Malpani , Gugan Thoppe , Sridharan Devarajan

Deep Learning-based computational pathology algorithms have demonstrated profound ability to excel in a wide array of tasks that range from characterization of well known morphological phenotypes to predicting non-human-identifiable…

Image and Video Processing · Electrical Eng. & Systems 2020-09-24 Ming Y. Lu , Dehan Kong , Jana Lipkova , Richard J. Chen , Rajendra Singh , Drew F. K. Williamson , Tiffany Y. Chen , Faisal Mahmood

Training deep neural networks usually requires a large amount of labeled data to obtain good performance. However, in medical image analysis, obtaining high-quality labels for the data is laborious and expensive, as accurately annotating…

Computer Vision and Pattern Recognition · Computer Science 2020-05-20 Quande Liu , Lequan Yu , Luyang Luo , Qi Dou , Pheng Ann Heng

Accurate diagnosis of disease often depends on the exhaustive examination of Whole Slide Images (WSI) at microscopic resolution. Efficient handling of these data-intensive images requires lossy compression techniques. This paper…

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