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In view of the fact that semi- and self-supervised learning share a fundamental principle, effectively modeling knowledge from unlabeled data, various semi-supervised semantic segmentation methods have integrated representative…

Computer Vision and Pattern Recognition · Computer Science 2024-11-15 Yangyang Li , Xuanting Hao , Ronghua Shang , Licheng Jiao

Self-supervised learning (SSL) has emerged as a promising paradigm for addressing the annotation bottleneck in medical imaging by learning representations from unlabeled data. However, its effectiveness depends heavily on the design of the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Chathura Wimalasiri

Multiple Instance Learning (MIL) methods have become increasingly popular for classifying giga-pixel sized Whole-Slide Images (WSIs) in digital pathology. Most MIL methods operate at a single WSI magnification, by processing all the tissue…

Computer Vision and Pattern Recognition · Computer Science 2022-07-27 Kevin Thandiackal , Boqi Chen , Pushpak Pati , Guillaume Jaume , Drew F. K. Williamson , Maria Gabrani , Orcun Goksel

Recent semi-supervised learning methods have shown to achieve comparable results to their supervised counterparts while using only a small portion of labels in image classification tasks thanks to their regularization strategies. In this…

Machine Learning · Computer Science 2020-09-25 Wei-Hong Li , Chuan-Sheng Foo , Hakan Bilen

Digital whole slides images contain an enormous amount of information providing a strong motivation for the development of automated image analysis tools. Particularly deep neural networks show high potential with respect to various tasks…

Computer Vision and Pattern Recognition · Computer Science 2023-12-07 Michael Gadermayr , Maximilian Tschuchnig

Real-world large-scale datasets are heteroskedastic and imbalanced -- labels have varying levels of uncertainty and label distributions are long-tailed. Heteroskedasticity and imbalance challenge deep learning algorithms due to the…

Machine Learning · Computer Science 2021-03-19 Kaidi Cao , Yining Chen , Junwei Lu , Nikos Arechiga , Adrien Gaidon , Tengyu Ma

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He

Regularization is an effective way to promote the generalization performance of machine learning models. In this paper, we focus on label smoothing, a form of output distribution regularization that prevents overfitting of a neural network…

Machine Learning · Computer Science 2020-07-07 Weizhi Li , Gautam Dasarathy , Visar Berisha

Spatial Transcriptomics (ST) profiles thousands of gene expression values at discrete spots with precise coordinates on tissue sections, preserving spatial context essential for clinical and pathological studies. With rising sequencing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Yishun Zhu , Jiaxin Qi , Jian Wang , Yuhua Zheng , Jianqiang Huang

Sclera segmentation is crucial for developing automatic eye-related medical computer-aided diagnostic systems, as well as for personal identification and verification, because the sclera contains distinct personal features. Deep…

Computer Vision and Pattern Recognition · Computer Science 2025-01-15 Guanjun Wang , Lu Wang , Ning Niu , Qiaoyi Yao , Yixuan Wang , Sufen Ren , Shengchao Chen

Neuroimaging studies based on magnetic resonance imaging (MRI) typically employ rigorous forms of preprocessing. Images are spatially normalized to a standard template using linear and non-linear transformations. Thus, one can assume that a…

Computer Vision and Pattern Recognition · Computer Science 2019-11-15 Fabian Eitel , Jan Philipp Albrecht , Friedemann Paul , Kerstin Ritter

Multi-Label Image Classification (MLIC) approaches usually exploit label correlations to achieve good performance. However, emphasizing correlation like co-occurrence may overlook discriminative features of the target itself and lead to…

Computer Vision and Pattern Recognition · Computer Science 2022-05-24 Jiazhi Xu , Sheng Huang , Fengtao Zhou , Luwen Huangfu , Daniel Zeng , Bo Liu

In many learning tasks, the structure of the target space of a function holds rich information about the relationships between evaluations of functions on different data points. Existing approaches attempt to exploit this relationship…

Computer Vision and Pattern Recognition · Computer Science 2016-02-12 Kwang In Kim , James Tompkin , Hanspeter Pfister , Christian Theobalt

In pathology, the spatial distribution and proportions of tissue types are key indicators of disease progression, and are more readily available than fine-grained annotations. However, these assessments are rarely mapped to pixel-wise…

Image and Video Processing · Electrical Eng. & Systems 2026-04-28 Yangping Li , Thomas Pinetz , Michael Hölzel , Marieta Toma , Alexander Effland

Multiple Instance Learning (MIL) is a sub-domain of classification problems with positive and negative labels and a "bag" of inputs, where the label is positive if and only if a positive element is contained within the bag, and otherwise is…

Machine Learning · Statistics 2023-10-30 Edward Raff , James Holt

Contrastive learning, which aims to capture general representation from unlabeled images to initialize the medical analysis models, has been proven effective in alleviating the high demand for expensive annotations. Current methods mainly…

Computer Vision and Pattern Recognition · Computer Science 2022-08-18 Huai Chen , Renzhen Wang , Xiuying Wang , Jieyu Li , Qu Fang , Hui Li , Jianhao Bai , Qing Peng , Deyu Meng , Lisheng Wang

Multiple instance learning (MIL)-based framework has become the mainstream for processing the whole slide image (WSI) with giga-pixel size and hierarchical image context in digital pathology. However, these methods heavily depend on a…

Computer Vision and Pattern Recognition · Computer Science 2025-02-13 Jiangbo Shi , Chen Li , Tieliang Gong , Yefeng Zheng , Huazhu Fu

Weakly supervised instance labeling using only image-level labels, in lieu of expensive fine-grained pixel annotations, is crucial in several applications including medical image analysis. In contrast to conventional instance segmentation…

Computer Vision and Pattern Recognition · Computer Science 2019-07-31 Jayaraman J. Thiagarajan , Satyananda Kashyap , Alexandros Karagyris

The success of deep learning methods in medical image segmentation tasks heavily depends on a large amount of labeled data to supervise the training. On the other hand, the annotation of biomedical images requires domain knowledge and can…

Computer Vision and Pattern Recognition · Computer Science 2021-09-30 Xinrong Hu , Dewen Zeng , Xiaowei Xu , Yiyu Shi

In this work, we propose the use of large set of unlabeled images as a source of regularization data for learning robust visual representation. Given a visual model trained by a labeled dataset in a supervised fashion, we augment our…

Computer Vision and Pattern Recognition · Computer Science 2018-02-08 Hamid Izadinia , Pierre Garrigues