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Large language models (LLMs) have shown impressive performance in following natural language instructions to solve unseen tasks. However, it remains unclear whether models truly understand task definitions and whether the human-written…

Computation and Language · Computer Science 2023-06-05 Fan Yin , Jesse Vig , Philippe Laban , Shafiq Joty , Caiming Xiong , Chien-Sheng Jason Wu

Current Large Vision-Language Models (LVLMs) have demonstrated remarkable capabilities in understanding multimodal data, but their potential remains underexplored for deepfake detection due to the misalignment of their knowledge and…

Computer Vision and Pattern Recognition · Computer Science 2025-06-10 Peipeng Yu , Jianwei Fei , Hui Gao , Xuan Feng , Zhihua Xia , Chip Hong Chang

Instruction-following is crucial for building AI agents with large language models (LLMs), as these models must adhere strictly to user-provided constraints and guidelines. However, LLMs often fail to follow even simple and clear…

Artificial Intelligence · Computer Science 2025-03-31 Juyeon Heo , Christina Heinze-Deml , Oussama Elachqar , Kwan Ho Ryan Chan , Shirley Ren , Udhay Nallasamy , Andy Miller , Jaya Narain

Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

Biomolecules · Quantitative Biology 2025-01-06 Weihang Dai

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

One emergent ability of large language models (LLMs) is that query-specific examples can be included in the prompt at inference time. In this work, we use active learning for adaptive prompt design and call it Active In-context Prompt…

Machine Learning · Computer Science 2024-06-03 Subhojyoti Mukherjee , Anusha Lalitha , Aniket Deshmukh , Ge Liu , Yifei Ma , Branislav Kveton

Large language models applied to vast biological datasets have the potential to transform biology by uncovering disease mechanisms and accelerating drug development. However, current models are often siloed, trained separately on…

Large language models (LLMs) such as ChatGPT are fine-tuned on large and diverse instruction-following corpora, and can generalize to new tasks. However, those instruction-tuned LLMs often perform poorly in specialized medical natural…

Computation and Language · Computer Science 2025-03-11 Yujuan Velvin Fu , Giridhar Kaushik Ramachandran , Namu Park , Kevin Lybarger , Fei Xia , Ozlem Uzuner , Meliha Yetisgen

We study the problem of completing various visual document understanding (VDU) tasks, e.g., question answering and information extraction, on real-world documents through human-written instructions. To this end, we propose InstructDoc, the…

Computer Vision and Pattern Recognition · Computer Science 2024-01-25 Ryota Tanaka , Taichi Iki , Kyosuke Nishida , Kuniko Saito , Jun Suzuki

This paper surveys research works in the quickly advancing field of instruction tuning (IT), which can also be referred to as supervised fine-tuning (SFT)\footnote{In this paper, unless specified otherwise, supervised fine-tuning (SFT) and…

Computation and Language · Computer Science 2025-10-07 Shengyu Zhang , Linfeng Dong , Xiaoya Li , Sen Zhang , Xiaofei Sun , Shuhe Wang , Jiwei Li , Runyi Hu , Tianwei Zhang , Fei Wu , Guoyin Wang

Large language models (LLMs) have shown remarkable performance in vision-language tasks, but their application in the medical field remains underexplored, particularly for integrating structured time series data with unstructured clinical…

Computation and Language · Computer Science 2025-06-17 Shuai Niu , Jing Ma , Hongzhan Lin , Liang Bai , Zhihua Wang , Wei Bi , Yida Xu , Guo Li , Xian Yang

Conventional mechanical design follows an iterative process in which initial concepts are refined through cycles of expert assessment and resource-intensive Finite Element Method (FEM) analysis to meet performance goals. While machine…

Machine Learning · Computer Science 2025-05-02 Yayati Jadhav , Amir Barati Farimani

Large language models (LLMs) are initially pretrained for broad capabilities and then finetuned with instruction-following datasets to improve their performance in interacting with humans. Despite advances in finetuning, a standardized…

Computation and Language · Computer Science 2024-07-30 Yihan Cao , Yanbin Kang , Chi Wang , Lichao Sun

Large language models (LLMs) have demonstrated remarkable abilities in representation learning for program synthesis and understanding tasks. The quality of the learned representations appears to be dictated by the neural scaling laws as a…

Machine Learning · Computer Science 2023-07-13 Erik Nijkamp , Hiroaki Hayashi , Caiming Xiong , Silvio Savarese , Yingbo Zhou

During times of increasing antibiotic resistance and the spread of infectious diseases like COVID-19, it is important to classify genes related to antibiotic resistance. As natural language processing has advanced with transformer-based…

Computation and Language · Computer Science 2024-01-02 Hyunwoo Yoo , Bahrad Sokhansanj , James R. Brown , Gail Rosen

Data annotation and synthesis generally refers to the labeling or generating of raw data with relevant information, which could be used for improving the efficacy of machine learning models. The process, however, is labor-intensive and…

Computation and Language · Computer Science 2024-12-04 Zhen Tan , Dawei Li , Song Wang , Alimohammad Beigi , Bohan Jiang , Amrita Bhattacharjee , Mansooreh Karami , Jundong Li , Lu Cheng , Huan Liu

Continuing advances in Large Language Models (LLMs) in artificial intelligence offer important capacities in intuitively accessing and using medical knowledge in many contexts, including education and training as well as assessment and…

Computation and Language · Computer Science 2024-08-01 Roma Shusterman , Allison C. Waters , Shannon O`Neill , Phan Luu , Don M. Tucker

Continual learning for video--language understanding is increasingly important as models face non-stationary data, domains, and query styles, yet prevailing solutions blur what should stay stable versus what should adapt, rely on static…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Mengzhu Xu , Hanzhi Liu , Ningkang Peng , Qianyu Chen , Canran Xiao

Pharmaceutical three-dimensional (3D) printing is an advanced fabrication technology with the potential to enable truly personalised dosage forms. Recent studies have integrated artificial intelligence (AI) to accelerate formulation and…

Artificial Intelligence · Computer Science 2026-05-19 Adeshola Okubena , Yusuf Ali Mohammed , Moe Elbadawi

Large language models (LLMs) have achieved state-of-the-art performance on a series of natural language understanding tasks. However, these LLMs might rely on dataset bias and artifacts as shortcuts for prediction. This has significantly…

Computation and Language · Computer Science 2023-05-09 Mengnan Du , Fengxiang He , Na Zou , Dacheng Tao , Xia Hu