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Instruction tuning plays a pivotal role in Code Large Language Models (Code LLMs) for the task of program synthesis. Presently, two dominant paradigms for collecting tuning data are natural-instruct (human-written) and self-instruct…

The performance of large language models (LLMs) is closely tied to their training data, which can include copyrighted material or private information, raising legal and ethical concerns. Additionally, LLMs face criticism for dataset…

This paper demonstrates that language models are strong structure-based protein designers. We present LM-Design, a generic approach to reprogramming sequence-based protein language models (pLMs), that have learned massive sequential…

Large Language Models (LLMs) have the potential to revolutionize data analytics by simplifying tasks such as data discovery and SQL query synthesis through natural language interactions. This work serves as a pivotal first step toward the…

The vast number of parameters in large language models (LLMs) endows them with remarkable capabilities, allowing them to excel in a variety of natural language processing tasks. However, this complexity also presents challenges, making LLMs…

Systematic identification of protein function is a key problem in current biology. Most traditional methods fail to identify functionally equivalent proteins if they lack similar sequences, structural data or extensive manual annotations.…

Fine-tuning-as-a-service introduces a threat to Large Language Models' safety when service providers fine-tune their models on poisoned user-submitted datasets, a process known as harmful fine-tuning attacks. In this work, we show that by…

Multimodal large language models (MLLMs) have shown remarkable performance in vision-language tasks. However, existing MLLMs are primarily trained on generic datasets, limiting their ability to reason on domain-specific visual cues such as…

Inspired by the exceptional general intelligence of Large Language Models (LLMs), researchers have begun to explore their application in pioneering the next generation of recommender systems - systems that are conversational, explainable,…

Understanding the intricate interplay among sequence, structure, and function remains a fundamental challenge in proteomics. The sequence-structure-function paradigm posits that biological roles are governed by the tertiary geometric…

Knowledge editing for large language models can offer an efficient solution to alter a model's behavior without negatively impacting the overall performance. However, the current approaches encounter issues with limited generalizability…

Large language models (LLMs) encode extensive world knowledge through pre-training on massive datasets, which can then be fine-tuned for the question-answering (QA) task. However, effective strategies for fine-tuning LLMs for the QA task…

This paper introduces MM-Instruct, a large-scale dataset of diverse and high-quality visual instruction data designed to enhance the instruction-following capabilities of large multimodal models (LMMs). While existing visual instruction…

Recently, deep learning has made rapid progress in antibody design, which plays a key role in the advancement of therapeutics. A dominant paradigm is to train a model to jointly generate the antibody sequence and the structure as a…

Spoken Language Understanding (SLU) is a core component of conversational systems, enabling machines to interpret user utterances. Despite its importance, developing effective SLU systems remains challenging due to the scarcity of labeled…

Large vision language models (LVLMs) have demonstrated impressive performance across a wide range of tasks. These capabilities largely stem from visual instruction tuning, which fine-tunes models on datasets consisting of curated…

Large language models (LLMs) have demonstrated notable potential in medical applications, yet they face substantial challenges in handling complex real-world clinical diagnoses using conventional prompting methods. Current prompt…

The prediction of amyloidogenicity in peptides and proteins remains a focal point of ongoing bioinformatics. The crucial step in this field is to apply advanced computational methodologies. Many recent approaches to predicting…

Large language models (LLMs) often suffer from catastrophic forgetting in continual learning: after learning new tasks sequentially, they perform worse on earlier tasks. Existing methods mitigate catastrophic forgetting by data replay,…

Lesion detection, symptom tracking, and visual explainability are central to real-world medical image analysis, yet current medical Vision-Language Models (VLMs) still lack mechanisms that translate their broad knowledge into clinically…