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In the era of large language models (LLMs), detecting pretraining data has been increasingly important due to concerns about fair evaluation and ethical risks. Current methods differentiate members and non-members by designing scoring…

Computation and Language · Computer Science 2025-03-18 Hengxiang Zhang , Songxin Zhang , Bingyi Jing , Hongxin Wei

Large Language Models (LLMs) have shown promising results on machine translation for high resource language pairs and domains. However, in specialised domains (e.g. medical) LLMs have shown lower performance compared to standard neural…

Computation and Language · Computer Science 2025-07-31 Miguel Rios

One of the primary driving forces contributing to the superior performance of Large Language Models (LLMs) is the extensive availability of human-annotated natural language data, which is used for alignment fine-tuning. This inspired…

Computation and Language · Computer Science 2024-06-18 Fangzhi Xu , Qiushi Sun , Kanzhi Cheng , Jun Liu , Yu Qiao , Zhiyong Wu

Prompting Large Language Models (LLMs), or providing context on the expected model of operation, is an effective way to steer the outputs of such models to satisfy human desiderata after they have been trained. But in rapidly evolving…

Machine Learning · Computer Science 2025-08-08 Younwoo Choi , Muhammad Adil Asif , Ziwen Han , John Willes , Rahul G. Krishnan

One core capability of Large Language Models (LLMs) is to follow natural language instructions. However, the evaluation of such abilities is not standardized: Human evaluations are expensive, slow, and not objectively reproducible, while…

Computation and Language · Computer Science 2023-11-15 Jeffrey Zhou , Tianjian Lu , Swaroop Mishra , Siddhartha Brahma , Sujoy Basu , Yi Luan , Denny Zhou , Le Hou

Large language models (LLMs) have demonstrated significant progress in multilingual language understanding and generation. However, due to the imbalance in training data, their capabilities in non-English languages are limited. Recent…

Computation and Language · Computer Science 2025-03-06 Wenshuai Huo , Xiaocheng Feng , Yichong Huang , Chengpeng Fu , Baohang Li , Yangfan Ye , Zhirui Zhang , Dandan Tu , Duyu Tang , Yunfei Lu , Hui Wang , Bing Qin

Large multimodal models (LMMs) excel in adhering to human instructions. However, self-contradictory instructions may arise due to the increasing trend of multimodal interaction and context length, which is challenging for language beginners…

Artificial Intelligence · Computer Science 2024-08-06 Jin Gao , Lei Gan , Yuankai Li , Yixin Ye , Dequan Wang

Instruction fine-tuning (IFT) elicits instruction following capabilities and steers the behavior of large language models (LLMs) via supervised learning. However, existing models trained on open-source IFT datasets only have the ability to…

Computation and Language · Computer Science 2024-09-24 Kuan Wang , Alexander Bukharin , Haoming Jiang , Qingyu Yin , Zhengyang Wang , Tuo Zhao , Jingbo Shang , Chao Zhang , Bing Yin , Xian Li , Jianshu Chen , Shiyang Li

Natural language processing (NLP) is a key technology to extract important patient information from clinical narratives to support healthcare applications. The rapid development of large language models (LLMs) has revolutionized many NLP…

Computation and Language · Computer Science 2025-09-08 Cheng Peng , Xinyu Dong , Mengxian Lyu , Daniel Paredes , Yaoyun Zhang , Yonghui Wu

Recently, the increasing demand for superior medical services has highlighted the discrepancies in the medical infrastructure. With big data, especially texts, forming the foundation of medical services, there is an exigent need for…

Computation and Language · Computer Science 2024-07-17 Yuanhe Tian , Ruyi Gan , Yan Song , Jiaxing Zhang , Yongdong Zhang

High-quality, large-scale instructions are crucial for aligning large language models (LLMs), however, there is a severe shortage of instruction in the field of natural language understanding (NLU). Previous works on constructing NLU…

Computation and Language · Computer Science 2025-02-07 Lin Yuan , Jun Xu , Honghao Gui , Mengshu Sun , Zhiqiang Zhang , Lei Liang , Jun Zhou

Large language models have emerged as a promising approach towards achieving general-purpose AI agents. The thriving open-source LLM community has greatly accelerated the development of agents that support human-machine dialogue interaction…

Computer Vision and Pattern Recognition · Computer Science 2023-11-07 Zhenfei Yin , Jiong Wang , Jianjian Cao , Zhelun Shi , Dingning Liu , Mukai Li , Lu Sheng , Lei Bai , Xiaoshui Huang , Zhiyong Wang , Jing Shao , Wanli Ouyang

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Artificial Intelligence · Computer Science 2025-04-21 Yijia Xiao , Edward Sun , Yiqiao Jin , Qifan Wang , Wei Wang

Accurate disease prediction is vital for timely intervention, effective treatment, and reducing medical complications. While symbolic AI has been applied in healthcare, its adoption remains limited due to the effort required for…

Artificial Intelligence · Computer Science 2026-01-01 Ioanna Gemou , Evangelos Lamprou

Proteins are fundamental biological entities that play a key role in life activities. The amino acid sequences of proteins can be folded into stable 3D structures in the real physicochemical world, forming a special kind of…

Machine Learning · Computer Science 2023-01-04 Lirong Wu , Yufei Huang , Haitao Lin , Stan Z. Li

Pre-trained protein models (PTPMs) represent a protein with one fixed embedding and thus are not capable for diverse tasks. For example, protein structures can shift, namely protein folding, between several conformations in various…

Artificial Intelligence · Computer Science 2022-02-08 Qiang Zhang , Zeyuan Wang , Yuqiang Han , Haoran Yu , Xurui Jin , Huajun Chen

Foundation models have revolutionized natural language processing and artificial intelligence, significantly enhancing how machines comprehend and generate human languages. Inspired by the success of these foundation models, researchers…

Recently, Vision-Language Models (VLMs) have achieved remarkable progress in multimodal tasks, and multimodal instruction data serves as the foundation for enhancing VLM capabilities. Despite the availability of several open-source…

Proteins, essential to biological systems, perform functions intricately linked to their three-dimensional structures. Understanding the relationship between protein structures and their amino acid sequences remains a core challenge in…

Quantitative Methods · Quantitative Biology 2024-11-04 Liang He , Peiran Jin , Yaosen Min , Shufang Xie , Lijun Wu , Tao Qin , Xiaozhuan Liang , Kaiyuan Gao , Yuliang Jiang , Tie-Yan Liu

The integration of large language model (LLM) techniques in the field of medical analysis has brought about significant advancements, yet the scarcity of large, diverse, and well-annotated datasets remains a major challenge. Medical data…

Computation and Language · Computer Science 2024-10-18 Wenhan Han , Meng Fang , Zihan Zhang , Yu Yin , Zirui Song , Ling Chen , Mykola Pechenizkiy , Qingyu Chen