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Multimode fibres are becoming increasingly attractive in optical endoscopy as they promise to enable unparalleled miniaturisation, spatial resolution and cost as compared to conventional fibre bundle-based counterpart. However, achieving…

Medical Physics · Physics 2024-06-05 Tianrui Zhao , Michelle T. Ma , Sebastien Ourselin , Tom Vercauteren , Wenfeng Xia

Wavefront shaping enables targeted delivery of coherent light into random-scattering media, such as biological tissue, by constructive interference of scattered waves. However, broadband waves have short coherence times, weakening the…

Biomedical imaging is unequivocally dependent on the ability to reconstruct interpretable and high-quality images from acquired sensor data. This reconstruction process is pivotal across many applications, spanning from magnetic resonance…

Signal Processing · Electrical Eng. & Systems 2019-09-24 Ben Luijten , Regev Cohen , Frederik J. de Bruijn , Harold A. W. Schmeitz , Massimo Mischi , Yonina C. Eldar , Ruud J. G. van Sloun

An integrated microscope that combines different optical techniques for simultaneous imaging is demonstrated. The microscope enables spectral-domain optical coherence microscopy based on optical backscatter, and multi-photon microscopy for…

Optics · Physics 2009-11-11 C. Vinegoni , T. Ralston , W. Tan , W. Luo , D. L. Marks , S. A. Boppart

Medical ultrasound provides images which are the spatial map of the tissue echogenicity. Unfortunately, an ultrasound image is a low-quality version of the expected Tissue Reflectivity Function (TRF) mainly due to the non-ideal Point Spread…

Image and Video Processing · Electrical Eng. & Systems 2021-09-28 Sobhan Goudarzi , Hassan Rivaz

We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light…

The intricate nature of the brain necessitates the application of advanced probing techniques to comprehensively study and understand its working mechanisms. Neurophotonics offers minimally invasive methods to probe the brain using optics…

Thanks to the latest advancements in wavefront shaping, optical methods have proven crucial to achieve imaging and control light in multiply scattering media, like biological tissues. However, the stability times of living biological…

Optics · Physics 2023-09-21 Lorenzo Valzania , Sylvain Gigan

In turbid media, scattering of light scrambles information of the incident beam and represents an obstacle to optical imaging. Noninvasive imaging through opaque layers is challenging for dynamic and wide-field objects due to unreliable…

Optics · Physics 2018-10-17 Yuan Yuan , Hui Chen

Ultrasound imaging is widely used in noninvasive medical diagnostics due to its efficiency, portability, and avoidance of ionizing radiation. However, its utility is limited by the quality of the signal. Signal-dependent speckle noise,…

Image and Video Processing · Electrical Eng. & Systems 2026-02-10 Soumee Guha , Scott T. Acton

Wavefront sensing and reconstruction are widely used for adaptive optics, aberration correction, and high-resolution optical phase imaging. Traditionally, interference and/or microlens arrays are used to convert the optical phase into…

Scattering hinders the passage of light through random media and consequently limits the usefulness of optical techniques for sensing and imaging. Thus, methods for increasing the transmission of light through such random media are of…

Optics · Physics 2014-06-23 Curtis Jin , Raj Rao Nadakuditi , Eric Michielssen , Stephen Rand

Light scattering by tissue severely limits how deep beneath the surface one can image, and the spatial resolution one can obtain from these images. Diffuse optical tomography (DOT) is one of the most powerful techniques for imaging deep…

Image and Video Processing · Electrical Eng. & Systems 2021-05-31 Yongyi Zhao , Ankit Raghuram , Hyun K. Kim , Andreas H. Hielscher , Jacob T. Robinson , Ashok Veeraraghavan

As an important branch of photoacoustic microscopy, optical-resolution photoacoustic microscopy suffers from limited depth of field due to the strongly focused laser beam. In this work, a 3D information fusion algorithm based on 3D…

Image and Video Processing · Electrical Eng. & Systems 2022-11-29 Xianlin Song , Sihang Li , Zhuangzhuang Wang

Humans possess a remarkable ability to integrate auditory and visual information, enabling a deeper understanding of the surrounding environment. This early fusion of audio and visual cues, demonstrated through cognitive psychology and…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Shentong Mo , Pedro Morgado

In the paper, combined bimodal microscopic visualization of biological objects based on reflection-mode optical and photoacoustic measurements was presented. Gasmicrophone configuration was chosen for the registration of photothermal…

Applied Physics · Physics 2021-11-01 Sergiy Litvinenko , Pavlo Lishchuk , Vladimir Lysenko , Mykola Isaiev

The increasing complexity of neural networks and the energy consumption associated with training and inference create a need for alternative neuromorphic approaches, e.g. using optics. Current proposals and implementations rely on physical…

Optics · Physics 2023-08-31 Clara C. Wanjura , Florian Marquardt

Light scattering limits the penetration depth of non-invasive Raman spectroscopy in biological media. While safe levels of irradiation may be adequate to analyze superficial tissue, scattering of the pump beam reduces the Raman signal to…

We deal with the photoacoustic imaging modality using dielectric nanoparticles as contrast agents. Exciting the heterogeneous tissue, localized in a bounded domain $\Omega$, with an electromagnetic wave, at a given incident frequency,…

Analysis of PDEs · Mathematics 2020-03-09 Ahcene Ghandriche , Mourad Sini

We enhanced the total transmission of light through a disordered waveguide with spatially inhomogeneous scattering and loss by shaping the incident wavefront of a laser beam. Using an on-chip tapered lead, we were able to access all input…

Optics · Physics 2017-03-20 Raktim Sarma , Alexey Yamilov , Hui Cao