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Non-invasively focusing light into strongly scattering media, such as biological tissue, is highly desirable but challenging. Recently, wavefront shaping technologies guided by ultrasonic encoding or photoacoustic sensing have been…

Optics · Physics 2014-02-05 Puxiang Lai , Lidai Wang , Jian Wei Tay , Lihong V. Wang

Photo-acoustic tomography is a coupled-physics (hybrid) medical imaging modality that aims to reconstruct optical parameters in biological tissues from ultrasound measurements. As propagating light gets partially absorbed, the resulting…

Analysis of PDEs · Mathematics 2020-01-08 Guillaume Bal , Adrian Kirkeby

Intraoperative optical imaging is essential for surgical precision and patient safety, but current systems present anatomical and fluorescence information separately, causing delays and increasing cognitive load. A unified system for…

Medical Physics · Physics 2025-09-22 Kyriakos Pentarakis , George Kakavelakis , Constantinos Petridis , George Themelis

After multiple scattering of quadrature-squeezed lights in a disordered medium, the quadrature amplitudes of the scattered modes present an excess noise above the shot-noise level [Opt. Expr. 14, 6919 (2006)]. A natural question is raised…

Quantum Physics · Physics 2020-01-08 Dong Li , Yao Yao

Encoding more information into wave fields is a central goal in imaging, communication, and wave control. Optical holography benefits from polarization multiplexing, but acoustic holography remains largely limited to pressure-only encoding…

Applied Physics · Physics 2026-04-28 Yuan Tian , Hao Ge , Jiangpo Zheng , Xiujuan Zhang , Ming-Hui Lu , Yan-Feng Chen

Aberrations limit scanning fluorescence microscopy when imaging in scattering materials such as biological tissue. Model-based approaches for adaptive optics take advantage of a computational model of the optical setup. Such models can be…

Optics · Physics 2021-07-07 Ivan Vishniakou , Johannes D. Seelig

As light travels through a disordered medium such as biological tissues, it undergoes multiple scattering events. This phenomenon is detrimental to in-depth optical microscopy, as it causes a drastic degradation of contrast, resolution and…

Optical approaches for wavefront shaping traditionally rely on phase modulation through holographic techniques. Shaping the phase determines a wave's diffraction and hence its intensity distribution in space. We instead show that shaping…

Multimodal medical image fusion plays a crucial role in medical diagnosis by integrating complementary information from different modalities to enhance image readability and clinical applicability. However, existing methods mainly follow…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Haozhe Xiang , Han Zhang , Yu Cheng , Xiongwen Quan , Wanwan Huang

Photoacoustic microscopy is becoming an important tool for the biomedical research. It has been widely used in biological researches, such as structural imaging of vasculature, brain structural and functional imaging, and tumor detection.…

Image and Video Processing · Electrical Eng. & Systems 2020-09-09 Xianlin Song , Jianshuang Wei , Lingfang Song

We present an ultra-thin hybrid imaging system based on an optical multimode fiber (MMF) and an optical fiber hydrophone that combines optical resolution photoacoustic and fluorescence microscopy. To control the illumination at the distal…

High-throughput biological imaging is often constrained by a trade-off between acquisition speed and image quality. Fast imaging modalities, such as wide-field fluorescence microscopy, enable large-scale data acquisition but suffer from…

Image and Video Processing · Electrical Eng. & Systems 2026-04-20 Dominik Panek , Carina Rząca , Maksymilian Szczypior , Joanna Sorysz , Krzysztof Misztal , Zbigniew Baster , Zenon Rajfur

The field of biomedical imaging has undergone a rapid growth in recent years, mostly due to the implementation of ad-hoc designed experimental setups, theoretical support methods and numerical reconstructions. Especially for biological…

Biological Physics · Physics 2017-06-30 Daniele Ancora

Scattering in complex media scrambles light, thus obscuring images and limiting applications from astronomy to microscopy. Existing computational and wavefront-shaping methods treat scattering as a linear optical-wave inversion problem that…

Quantum Physics · Physics 2026-03-18 Chloé Vernière , Raphaël Guitter , Baptiste Courme , Hugo Defienne

Fluorescence imaging is an essential diagnostic tool in many fields, but diffraction-limited optical imaging at depth is limited by scattering. Here, we present a method based on multiple random illuminations, combined with a computational…

Optics · Physics 2026-03-30 Lei Zhu , Tengfei Wu , Bernhard Rauer , Hilton B. de Aguiar , Sylvain Gigan

Fluorescent imaging plays a critical role in a myriad of scientific endeavors, particularly in the biological sciences. Three-dimensional imaging of fluorescent intensity often requires serial data acquisition, that is voxel-by-voxel…

Optics · Physics 2015-10-27 Jeffrey J. Field , David G. Winters , Randy A. Bartels

Photoacoustic tomography (PAT) offers optical contrast, whereas magnetic resonance imaging (MRI) excels in imaging soft tissue and organ anatomy. The fusion of PAT with MRI holds promising application prospects due to their complementary…

Image and Video Processing · Electrical Eng. & Systems 2025-03-20 Yutian Zhong , Jinchuan He , Zhichao Liang , Shuangyang Zhang , Qianjin Feng , Lijun Lu , Li Qi

We propose a novel technique of microscopy to overcome the effects of both scattering and limitation of the accessible depth due to the objective working distance. By combining Laser Optical Feedback Imaging (LOFI) with Acoustic Photon…

Medical image fusion integrates the complementary diagnostic information of the source image modalities for improved visualization and analysis of underlying anomalies. Recently, deep learning-based models have excelled the conventional…

Image and Video Processing · Electrical Eng. & Systems 2023-10-19 Manisha Das , Deep Gupta , Petia Radeva , Ashwini M Bakde

Entangled photons provide transformative new paths in the fields of communication, sensing, and computing. However, when entangled photons propagate through a complex medium such as a biological tissue or a turbulent atmosphere, their…

Quantum Physics · Physics 2024-08-30 Ronen Shekel , Ohad Lib , Yaron Bromberg
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