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In clinical practice, tri-modal medical image fusion, compared to the existing dual-modal technique, can provide a more comprehensive view of the lesions, aiding physicians in evaluating the disease's shape, location, and biological…

Image and Video Processing · Electrical Eng. & Systems 2024-10-16 Yushen Xu , Xiaosong Li , Yuchan Jie , Haishu Tan

Recently, fluorescence-based optical techniques have emerged as a powerful tool to probe information in the mammalian brain. However, tissue heterogeneities prevent clear imaging of deep neuron bodies due to light scattering. While several…

Photoacoustic imaging is an emerging technology based on the photoacoustic effect that has developed rapidly in recent years. It combines the high contrast of optical imaging and the high penetration and high resolution of acoustic imaging.…

Confocal and multiphoton microscopy are effective techniques to obtain high-contrast images of 2-D sections within bulk tissue. However, scattering limits their application to depths only up to ~1 millimeter. Multimode fibers make excellent…

Optics · Physics 2022-02-23 Sakshi Singh , Simon Labouesse , Rafael Piestun

Wavefront shaping enables control of classical light through scattering media. Extending these techniques to spatially entangled photons promises new quantum applications, but their fundamental limits, especially when both photons scatter,…

Quantum Physics · Physics 2025-05-06 Ronen Shekel , Sébastien M. Popoff , Yaron Bromberg

Imaging through scattering is a pervasive and difficult problem in many biological applications. The high background and the exponentially attenuated target signals due to scattering fundamentally limits the imaging depth of fluorescence…

Signal Processing · Electrical Eng. & Systems 2023-12-11 Jeffrey Alido , Joseph Greene , Yujia Xue , Guorong Hu , Yunzhe Li , Mitchell Gilmore , Kevin J. Monk , Brett T. DiBenedictis , Ian G. Davison , Lei Tian

Photoacoustic microscopy with large depth of focus is significant to the biomedical research. The conventional optical-resolution photoacoustic microscope (OR-PAM) suffers from limited depth of field (DoF) since the employed focused…

Image and Video Processing · Electrical Eng. & Systems 2020-09-07 Xianlin Song , Jianshuang Wei , Lingfang Song

Multimode fibers (MMFs) can transmit multiple guided modes simultaneously, making them a promising platform for high-resolution biomedical imaging, endoscopy and high-bandwidth optical communication. However, their complex modal behavior,…

Optics · Physics 2026-05-28 Dvir Marsh , Lior Fridman , Stav Lotan , Amit Kam , Shie Mannor , Guy Bartal

Fluorescence is a powerful mean to probe information processing in the mammalian brain. However, neuronal tissues are highly heterogeneous and thus opaque to light. A wide set of non-invasive or invasive techniques for scattered light…

Optics · Physics 2020-05-11 Claudio Moretti , Sylvain Gigan

Various imaging techniques have significantly enhanced our ability to visualize objects embedded within complex media such as biological tissues, fog, atmosphere, or various turbid media. Optical imaging, in particular, offers multiple…

Optics · Physics 2025-05-05 Mingwei He , Sujit K. Sahoo , Chengyuan Xiao , Cuong Dang

Light scattering in inhomogeneous media induces wavefront distortions which pose an inherent limitation in many optical applications. Examples range from microscopy and nanosurgery to astronomy. In recent years, ongoing efforts have made…

Optics · Physics 2015-05-20 Ori Katz , Yaron Bromberg , Eran Small , Yaron Silberberg

We report a new coherent imaging technique, termed ptychographic structured modulation (PSM), for quantitative super-resolution microscopy. In this technique, we place a thin diffuser (i.e., a scattering lens) in between the sample and the…

Image and Video Processing · Electrical Eng. & Systems 2019-07-26 Pengming Song , Shaowei Jiang , He Zhang , Zichao Bian , Chengfei Guo , Kazunori Hoshino , Guoan Zheng

The applications of vortex beam in biomedical field are always hindered by light scattering of biological tissues. Recently wavefront shaping technology has shown the potential in focusing a structured light field through scattering media.…

Optics · Physics 2020-04-07 Hengkang Zhang , Bin Zhang , Zhensong Wan , Qiang Liu

We implement the photoacoustic transmission-matrix approach on a two-dimensional photoacoustic imaging system, using a 15 MHz linear ultrasound array. Using a black leaf skeleton as a complex absorbing structure, we demonstrate that the…

Optics · Physics 2017-11-15 Thomas Chaigne , Jerome Gateau , Ori Katz , Emmanuel Bossy , Sylvain Gigan

Two-photon microscopy is a powerful tool for in vivo imaging, but its imaging depth is typically limited to a few hundred microns due to tissue scattering, even with existing scattering correction techniques. Moreover, most active…

Optics · Physics 2025-05-29 Renzhi He , Yucheng Li , Brianna Urbina , Jiandi Wan , Yi Xue

Imaging through complex scattering media is severely limited by aberrations and scattering which obscure images and reduce resolution. Confocal and temporal gatings partly filter out multiple scattering but are severely degraded by…

Optics · Physics 2026-05-18 Yiwen Zhang , Minh Dinh , Zeyu Wang , Tianhao Zhang , Tianhang Chen , Chia Wei Hsu

Multimode fibers recently emerged as compact minimally-invasive probes for high-resolution deep-tissue imaging. However, the commonly used silica fibers have a relatively low numerical aperture (NA) limiting the spatial resolution of a…

Optics · Physics 2024-07-09 Zhouping Lyu , Lyubov Amitonova

Deep-tissue optical imaging is a longstanding challenge limited by scattering. Both optical imaging and treatment can benefit from focusing light in deep tissue beyond one transport mean free path. Wavefront shaping based on time-reversed…

Optics · Physics 2020-12-09 Juze Zhang , Zijian Gao , Xiaopeng Yu , Peng Ge , Feng Gao , Fei Gao

Imaging an object embedded within a scattering medium requires the correction of complex sample-induced wave distortions. Existing approaches have been designed to resolve them by optimizing signal waves recorded in each 2D image. Here, we…

Optics · Physics 2022-10-17 Ye-Ryoung Lee , Dong-Young Kim , Yonghyeon Jo , Moonseok Kim , Wonshik Choi

Photoacoustic imaging systems offer a platform with high resolution to explore body tissues, food, and artwork. On the other hand, plasmonics constitutes a source of resonant heating and thermal expansion to generate acoustic waves.…

Applied Physics · Physics 2022-08-29 Ricardo Martín Abraham-Ekeroth
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