Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping
Optics
2015-10-29 v2
Abstract
We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and to focus light on the target cells. We demonstrate that illumination with shaped waves enables spatiotemporal regulation of intracellular Ca2+ level at the individual-cell level.
Keywords
Cite
@article{arxiv.1502.04826,
title = {Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping},
author = {Jonghee Yoon and Minji Lee and KyeoReh Lee and Nury Kim and Jin Man Kim and Jongchan Park and Chulhee Choi and Won Do Heo and YongKeun Park},
journal= {arXiv preprint arXiv:1502.04826},
year = {2015}
}