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Despite being widely used to support clinical care, general-purpose large multimodal models (LMMs) have generally shown poor or inconclusive performance in medical image interpretation, particularly in pathology, where gigapixel images are…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Thomas A. Buckley , Kian R. Weihrauch , Katherine Latham , Andrew Z. Zhou , Padmini A. Manrai , Arjun K. Manrai

Segmenting stroke lesions from T1-weighted MR images is of great value for large-scale stroke rehabilitation neuroimaging analyses. Nevertheless, there are great challenges with this task, such as large range of stroke lesion scales and the…

Image and Video Processing · Electrical Eng. & Systems 2021-02-17 Hao Yang , Weijian Huang , Kehan Qi , Cheng Li , Xinfeng Liu , Meiyun Wang , Hairong Zheng , Shanshan Wang

Efficient path planning in robotics, particularly within large-scale, complex environments, remains a significant hurdle. While Large Language Models (LLMs) offer strong reasoning capabilities, their high computational cost and limited…

Recent advances in whole slide imaging (WSI) technology have led to the development of a myriad of computer vision and artificial intelligence (AI) based diagnostic, prognostic, and predictive algorithms. Computational Pathology (CPath)…

Image analysis and machine learning algorithms operating on multi-gigapixel whole-slide images (WSIs) often process a large number of tiles (sub-images) and require aggregating predictions from the tiles in order to predict WSI-level…

Computer Vision and Pattern Recognition · Computer Science 2022-11-03 Mohsin Bilal , Robert Jewsbury , Ruoyu Wang , Hammam M. AlGhamdi , Amina Asif , Mark Eastwood , Nasir Rajpoot

Large Multimodal Models (LMMs) have shown significant visual reasoning capabilities by connecting a visual encoder and a large language model. LMMs typically take in a fixed and large amount of visual tokens, such as the penultimate layer…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Yuzhang Shang , Mu Cai , Bingxin Xu , Yong Jae Lee , Yan Yan

This paper introduces the novel concept of few-shot weakly supervised learning for pathology Whole Slide Image (WSI) classification, denoted as FSWC. A solution is proposed based on prompt learning and the utilization of a large language…

Computer Vision and Pattern Recognition · Computer Science 2024-01-30 Linhao Qu , Xiaoyuan Luo , Kexue Fu , Manning Wang , Zhijian Song

Recent advances in vision-language models (VLMs) have shown remarkable potential in bridging visual and textual modalities. In computational pathology, domain-specific VLMs, which are pre-trained on extensive histopathology image-text…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Anh Tien Nguyen , Keunho Byeon , Kyungeun Kim , Jin Tae Kwak

Multimodal Large Language Models (MLLMs) have shown immense promise in universal multimodal retrieval, which aims to find relevant items of various modalities for a given query. But their practical application is often hindered by the…

Computer Vision and Pattern Recognition · Computer Science 2026-02-06 Qi Li , Yanzhe Zhao , Yongxin Zhou , Yameng Wang , Yandong Yang , Yuanjia Zhou , Jue Wang , Zuojian Wang , Jinxiang Liu

Small Language Models (SLMs, or on-device LMs) have significantly fewer parameters than Large Language Models (LLMs). They are typically deployed on low-end devices, like mobile phones and single-board computers. Unlike LLMs, which rely on…

Computation and Language · Computer Science 2025-06-17 Mingxue Xu , Yao Lei Xu , Danilo P. Mandic

Whole Slide Image (WSI) classification has very significant applications in clinical pathology, e.g., tumor identification and cancer diagnosis. Currently, most research attention is focused on Multiple Instance Learning (MIL) using static…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Jiaxiang Gou , Luping Ji , Pei Liu , Mao Ye

Large language models deliver strong generative performance but at the cost of massive parameter counts, memory use, and decoding latency. Prior work has shown that pruning and structured sparsity can preserve accuracy under substantial…

Computation and Language · Computer Science 2026-04-17 Andrew Kiruluta

Visual tokens consume substantial computational resources in multi-modal large models (MLLMs), significantly compromising their efficiency. Recent works have attempted to improve efficiency by compressing visual tokens during training,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-02 Zichen Wen , Shaobo Wang , Yufa Zhou , Junyuan Zhang , Qintong Zhang , Yifeng Gao , Zhaorun Chen , Bin Wang , Weijia Li , Conghui He , Linfeng Zhang

Whole slide images (WSIs) enable weakly supervised prognostic modeling via multiple instance learning (MIL). Spatial transcriptomics (ST) preserves in situ gene expression, providing a spatial molecular context that complements morphology.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Lihe Liu , Xiaoxi Pan , Yinyin Yuan , Lulu Shang

Concolic testing, a powerful hybrid software testing technique, has historically been plagued by fundamental limitations such as path explosion and the high cost of constraint solving, which hinder its practical application in large-scale,…

Software Engineering · Computer Science 2026-01-21 Mahdi Eslamimehr

Existing WSI analysis methods lie on the consensus that histopathological characteristics of tumors are significant guidance for cancer diagnostics. Particularly, as the evolution of cancers is a continuous process, the correlations and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Tong Shu , Jun Shi , Dongdong Sun , Zhiguo Jiang , Yushan Zheng

Large vision-language models (LVLMs) achieve strong multimodal understanding, but their inference cost grows rapidly with the number of visual tokens, especially for high-resolution images and long videos. Existing attention-based methods…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Hongyu Lu , Feng Zhang , Wenwei Jin , Huanling Hu , Tianjun Shi , Shikai Jiang , Yao Hu , Jiawei Li

Large language models (LLMs) often face a trade-off in post-training: improvements on specialized domains frequently come at the expense of general capabilities. Existing solutions attempt to mitigate this tension via regularization,…

Machine Learning · Computer Science 2025-10-13 Suming Qiu , Jing Li , Zhicheng Zhou , Junjie Huang , Linyuan Qiu , Zhijie Sun

Large Language Models (LLMs) incur significant computational and memory costs when processing long prompts, as full self-attention scales quadratically with input length. Token compression aims to address this challenge by reducing the…

Computation and Language · Computer Science 2026-04-23 Zihao Xu , John Harvill , Ziwei Fan , Yizhou Sun , Hao Ding , Hao Wang

The integration of DNA methylation data with a Whole Slide Image (WSI) offers significant potential for enhancing the diagnostic precision of central nervous system (CNS) tumor classification in neuropathology. While existing approaches…

Computer Vision and Pattern Recognition · Computer Science 2024-12-12 Omnia Alwazzan , Amaya Gallagher-Syed , Thomas O. Millner , Sebastian Brandner , Ioannis Patras , Silvia Marino , Gregory Slabaugh
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