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The development of computational pathology lies in the consensus that pathological characteristics of tumors are significant guidance for cancer diagnostics. Most existing research focuses on the inner-contextual information within each WSI…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Jun Shi , Tong Shu , Zhiguo Jiang , Wei Wang , Haibo Wu , Yushan Zheng

Accurate analysis of histopathological images is critical for disease diagnosis and treatment planning. Whole-slide images (WSIs), which digitize tissue specimens at gigapixel resolution, are fundamental to this process but require…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Enhui Chai , Sicheng Chen , Tianyi Zhang , Chad Wong , Kecheng Huang , Zeyu Liu , Fei Xia

Large language models (LLMs) are typically trained on general source data for various domains, but a recent surge in domain-specific LLMs has shown their potential to outperform general-purpose models in domain-specific tasks (e.g.,…

Computation and Language · Computer Science 2024-08-09 Vithursan Thangarasa , Mahmoud Salem , Shreyas Saxena , Kevin Leong , Joel Hestness , Sean Lie

Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Lifelong learning on Whole Slide Images (WSIs) aims to train or fine-tune a unified model sequentially on cancer-related tasks, reducing the resources and effort required for data transfer and processing, especially given the gigabyte-scale…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Doanh C. Bui , Ba Hung Ngo , Hoai Luan Pham , Khang Nguyen , Maï K. Nguyen , Yasuhiko Nakashima

Recently, Referring Image Segmentation (RIS) frameworks that pair the Multimodal Large Language Model (MLLM) with the Segment Anything Model (SAM) have achieved impressive results. However, adapting MLLM to segmentation is computationally…

Computer Vision and Pattern Recognition · Computer Science 2025-09-18 Xiaobo Yang , Xiaojin Gong

Recent advances in histopathology vision-language foundation models (VLFMs) have shown promise in addressing data scarcity for whole slide image (WSI) classification via zero-shot adaptation. However, these methods remain outperformed by…

Computer Vision and Pattern Recognition · Computer Science 2025-08-14 Tianqi Xiang , Yi Li , Qixiang Zhang , Xiaomeng Li

Healthcare applications are inherently multimodal, benefiting greatly from the integration of diverse data sources. However, the modalities available in clinical settings can vary across different locations and patients. A key area that…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Mohammed Amer , Mohamed A. Suliman , Tu Bui , Nuria Garcia , Serban Georgescu

Large Language Models (LLMs) show potential for enhancing robotic path planning. This paper assesses visual input's utility for multimodal LLMs in such tasks via a comprehensive benchmark. We evaluated 15 multimodal LLMs on generating valid…

Robotics · Computer Science 2025-07-17 Jacinto Colan , Ana Davila , Yasuhisa Hasegawa

Large Language Models (LLMs) have demonstrated exceptional performance across diverse tasks. However, their deployment in long-context scenarios faces high computational overhead and information redundancy. While soft prompt compression has…

Computation and Language · Computer Science 2026-05-12 Jiwei Tang , Zhijing Huang , Xinyu Zhang , Chen Jason Zhang , Jianxing Yu , Libin Zheng , Rui Meng , Jian Yin

Recent advancements in Large Vision-Language Models built upon Large Language Models have established aligning visual features with LLM representations as the dominant paradigm. However, inherited LLM architectural designs introduce…

Computer Vision and Pattern Recognition · Computer Science 2025-06-09 Shi Liu , Weijie Su , Xizhou Zhu , Wenhai Wang , Jifeng Dai

Cropping high-resolution document images into multiple sub-images is the most widely used approach for current Multimodal Large Language Models (MLLMs) to do document understanding. Most of current document understanding methods preserve…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Renshan Zhang , Yibo Lyu , Rui Shao , Gongwei Chen , Weili Guan , Liqiang Nie

Whole slide images (WSI) are microscopy images of stained tissue slides routinely prepared for diagnosis and treatment selection in medical practice. WSI are very large (gigapixel size) and complex (made of up to millions of cells). The…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tristan Lazard , Marvin Lerousseau , Etienne Decencière , Thomas Walter

Vision Language Models (VLMs) like CLIP have attracted substantial attention in pathology, serving as backbones for applications such as zero-shot image classification and Whole Slide Image (WSI) analysis. Additionally, they can function as…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Yuxuan Sun , Yunlong Zhang , Yixuan Si , Chenglu Zhu , Zhongyi Shui , Kai Zhang , Jingxiong Li , Xingheng Lyu , Tao Lin , Lin Yang

Large Multimodal Models (LMMs) are powerful tools that are capable of reasoning and understanding multimodal information beyond text and language. Despite their entrenched impact, the development of LMMs is hindered by the higher…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Vittorio Pippi , Matthieu Guillaumin , Silvia Cascianelli , Rita Cucchiara , Maximilian Jaritz , Loris Bazzani

Large language models (LLMs) deliver impressive performance but incur prohibitive memory and compute costs at deployment. Model pruning is an effective way to reduce these overheads, yet existing approaches face challenges: unstructured…

Machine Learning · Computer Science 2026-04-30 Younes Hourri , Mohammad Mozaffari , Maryam Mehri Dehnavi

In this work, we discuss building performant Multimodal Large Language Models (MLLMs). In particular, we study the importance of various architecture components and data choices. Through careful and comprehensive ablations of the image…

Whole slide images (WSIs) are the gold standard for pathological diagnosis and sub-typing. Current main-stream two-step frameworks employ offline feature encoders trained without domain-specific knowledge. Among them, attention-based…

Computer Vision and Pattern Recognition · Computer Science 2026-02-17 Mingrui Ma , Chentao Li , Pan Huang , Jing Qin

Multiple Instance Learning (MIL) has advanced WSI analysis but struggles with the complexity and heterogeneity of WSIs. Existing MIL methods face challenges in aggregating diverse patch information into robust WSI representations. While…

Computer Vision and Pattern Recognition · Computer Science 2025-07-28 Beidi Zhao , SangMook Kim , Hao Chen , Chen Zhou , Zu-hua Gao , Gang Wang , Xiaoxiao Li

Vision-Language Models (VLMs) have shown strong performance in zero-shot image classification tasks. However, existing methods, including Contrastive Language-Image Pre-training (CLIP), all rely on annotated text-to-image pairs for aligning…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Dianxing Shi , Dingjie Fu , Yuqiao Liu , Jun Wang
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