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Multiple instance learning (MIL) has emerged as a powerful framework for weakly supervised whole slide image (WSI) classification, enabling slide-level predictions without requiring detailed patch-level annotations. Despite its success, a…

Computer Vision and Pattern Recognition · Computer Science 2025-07-25 Bryan Wong , Mun Yong Yi

In recent years, the availability of digitized Whole Slide Images (WSIs) has enabled the use of deep learning-based computer vision techniques for automated disease diagnosis. However, WSIs present unique computational and algorithmic…

Image and Video Processing · Electrical Eng. & Systems 2021-06-15 Yash Sharma , Aman Shrivastava , Lubaina Ehsan , Christopher A. Moskaluk , Sana Syed , Donald E. Brown

The multi-scale information among the whole slide images (WSIs) is essential for cancer diagnosis. Although the existing multi-scale vision Transformer has shown its effectiveness for learning multi-scale image representation, it still…

Computer Vision and Pattern Recognition · Computer Science 2023-05-26 Saisai Ding , Juncheng Li , Jun Wang , Shihui Ying , Jun Shi

Large Vision-Language Models (VLMs) exhibit impressive multi-modal capabilities but suffer from prohibitive computational and memory demands, due to their long visual token sequences and massive parameter sizes. To address these issues,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Chengtao Lv , Bilang Zhang , Yang Yong , Ruihao Gong , Yushi Huang , Shiqiao Gu , Jiajun Wu , Yumeng Shi , Jinyang Guo , Wenya Wang

Multimodal Large Language Models (MLLMs) suffer from substantial computational overhead due to the high redundancy in visual token sequences. Existing approaches typically address this issue using single-layer Vision Transformer (ViT)…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Yunkai Dang , Yizhu Jiang , Yifan Jiang , Qi Fan , Yinghuan Shi , Wenbin Li , Yang Gao

Computational methods on analyzing Whole Slide Images (WSIs) enable early diagnosis and treatments by supporting pathologists in detection and classification of tumors. However, the extremely high resolution of WSIs makes end-to-end…

Computer Vision and Pattern Recognition · Computer Science 2026-03-18 Umar Marikkar , Muhammad Awais , Sara Atito

In Computational Pathology (CPath), the introduction of Vision-Language Models (VLMs) has opened new avenues for research, focusing primarily on aligning image-text pairs at a single magnification level. However, this approach might not be…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Shahad Albastaki , Anabia Sohail , Iyyakutti Iyappan Ganapathi , Basit Alawode , Asim Khan , Sajid Javed , Naoufel Werghi , Mohammed Bennamoun , Arif Mahmood

The rapidly emerging field of deep learning-based computational pathology has shown promising results in utilizing whole slide images (WSIs) to objectively prognosticate cancer patients. However, most prognostic methods are currently…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Mingxin Liu , Yunzan Liu , Hui Cui , Chunquan Li , Jiquan Ma

Accurate diagnosis of disease often depends on the exhaustive examination of Whole Slide Images (WSI) at microscopic resolution. Efficient handling of these data-intensive images requires lossy compression techniques. This paper…

Prompt learning has emerged as a promising paradigm for adapting pre-trained vision-language models (VLMs) to few-shot whole slide image (WSI) classification by aligning visual features with textual representations, thereby reducing…

Computer Vision and Pattern Recognition · Computer Science 2025-10-01 Junjie Zhou , Wei Shao , Yagao Yue , Wei Mu , Peng Wan , Qi Zhu , Daoqiang Zhang

Artificial Intelligence (AI) has great potential to improve health outcomes by training systems on vast digitized clinical datasets. Computational Pathology, with its massive amounts of microscopy image data and impact on diagnostics and…

Image and Video Processing · Electrical Eng. & Systems 2024-05-24 Gabriele Campanella , Eugene Fluder , Jennifer Zeng , Chad Vanderbilt , Thomas J. Fuchs

Low-rank and sparse composite approximation is a natural idea to compress Large Language Models (LLMs). However, such an idea faces two primary challenges that adversely affect the performance of existing methods. The first challenge…

Machine Learning · Computer Science 2026-02-27 Changhai Zhou , Qian Qiao , Yuhua Zhou , Yuxin Wu , Shichao Weng , Weizhong Zhang , Cheng Jin

Multimodal large language models (MLLMs) have made remarkable strides, largely driven by their ability to process increasingly long and complex contexts, such as high-resolution images, extended video sequences, and lengthy audio input.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Kele Shao , Keda Tao , Kejia Zhang , Sicheng Feng , Mu Cai , Yuzhang Shang , Haoxuan You , Can Qin , Yang Sui , Huan Wang

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang

Survival prediction, utilizing pathological images and genomic profiles, is increasingly important in cancer analysis and prognosis. Despite significant progress, precise survival analysis still faces two main challenges: (1) The massive…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Songhan Jiang , Zhengyu Gan , Linghan Cai , Yifeng Wang , Yongbing Zhang

Making large language models (LLMs) more efficient in memory, latency, and serving cost is crucial for edge deployment, interactive applications, and sustainable inference at scale. Pruning is a promising technique, but existing pruning…

Computation and Language · Computer Science 2025-10-13 Eugene Kwek , Wenpeng Yin

Recent studies in long video understanding have harnessed the advanced visual-language reasoning capabilities of Large Multimodal Models (LMMs), driving the evolution of video-LMMs specialized for processing extended video sequences.…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Janghoon Cho , Jungsoo Lee , Munawar Hayat , Kyuwoong Hwang , Fatih Porikli , Sungha Choi

Despite the remarkable performance of multimodal large language models (MLLMs) across diverse tasks, the substantial training and inference costs impede their advancement. In this paper, we propose p-MoD, an efficient MLLM architecture that…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Jun Zhang , Desen Meng , Zhengming Zhang , Zhenpeng Huang , Tao Wu , Limin Wang

Processing histopathological Whole Slide Images (WSI) leads to massive storage requirements for clinics worldwide. Even after lossy image compression during image acquisition, additional lossy compression is frequently possible without…

Multimodal Large Language Models (MLLMs) have shown remarkable versatility in understanding diverse multimodal data and tasks. However, these capabilities come with an increased model scale. While post-training pruning reduces model size in…

Computer Vision and Pattern Recognition · Computer Science 2025-05-20 Jaewoo Lee , Keyang Xuan , Chanakya Ekbote , Sandeep Polisetty , Yi R. Fung , Paul Pu Liang