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Individuals are increasingly generating substantial personal health and lifestyle data, e.g. through wearables and smartphones. While such data could transform preventative care, its integration into clinical practice is hindered by its…

Human-Computer Interaction · Computer Science 2026-02-16 Pavithren V S Pakianathan , Rania Islambouli , Diogo Branco , Albrecht Schmidt , Tiago Guerreiro , Jan David Smeddinck

Large language models (LLMs) are entering clinician workflows, yet evaluations rarely measure how clinician reasoning shapes model behavior during clinical interactions. We combined 61 New England Journal of Medicine Case Records with 92…

Synthetic data augmentation via large language models (LLMs) allows researchers to leverage additional training data, thus enhancing the performance of downstream tasks, especially when real-world data is scarce. However, the generated data…

Machine Learning · Computer Science 2025-03-25 Hsun-Yu Kuo , Yin-Hsiang Liao , Yu-Chieh Chao , Wei-Yun Ma , Pu-Jen Cheng

The difficulty of anonymizing text data hinders the development and deployment of NLP in high-stakes domains that involve private data, such as healthcare and social services. Poorly anonymized sensitive data cannot be easily shared with…

Computation and Language · Computer Science 2024-10-14 Krithika Ramesh , Nupoor Gandhi , Pulkit Madaan , Lisa Bauer , Charith Peris , Anjalie Field

Existing detectors are often trained on biased datasets, leading to the possibility of overfitting on non-causal image attributes that are spuriously correlated with real/synthetic labels. While these biased features enhance performance on…

Computer Vision and Pattern Recognition · Computer Science 2025-10-22 Ruoxin Chen , Junwei Xi , Zhiyuan Yan , Ke-Yue Zhang , Shuang Wu , Jingyi Xie , Xu Chen , Lei Xu , Isabel Guan , Taiping Yao , Shouhong Ding

This study evaluates the linguistic and clinical suitability of synthetic electronic health records in mental health. First, we describe the rationale and the methodology for creating the synthetic corpus. Second, we examine expressions of…

Computation and Language · Computer Science 2026-02-05 Serge Sharoff , John Baker , David Francis Hunt , Alan Simpson

Recent years have witnessed a growing academic and industrial interest in deep learning (DL) for medical imaging. To perform well, DL models require very large labeled datasets. However, most medical imaging datasets are small, with a…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Minh H. Vu , Lorenzo Tronchin , Tufve Nyholm , Tommy Löfstedt

Dementia is a growing problem as our society ages, and detection methods are often invasive and expensive. Recent deep-learning techniques can offer a faster diagnosis and have shown promising results. However, they require large amounts of…

Computation and Language · Computer Science 2022-07-19 Anna Hlédiková , Dominika Woszczyk , Alican Akman , Soteris Demetriou , Björn Schuller

Artificial intelligence (AI) is increasingly used in every stage of drug development. Continuing breakthroughs in AI-based methods for drug discovery require the creation, improvement, and refinement of drug discovery data. We posit a new…

Machine Learning · Computer Science 2024-05-08 Bing Hu , Ashish Saragadam , Anita Layton , Helen Chen

In recent years, with the rapid advancements in large language models (LLMs), achieving excellent empathetic response capabilities has become a crucial prerequisite. Consequently, managing and understanding empathetic datasets have gained…

Computation and Language · Computer Science 2024-08-13 Hao Liang , Linzhuang Sun , Jingxuan Wei , Xijie Huang , Linkun Sun , Bihui Yu , Conghui He , Wentao Zhang

Data quality is the key factor for the development of trustworthy AI in healthcare. A large volume of curated datasets with controlled confounding factors can help improve the accuracy, robustness and privacy of downstream AI algorithms.…

Machine Learning · Computer Science 2022-09-21 Xiaodan Xing , Huanjun Wu , Lichao Wang , Iain Stenson , May Yong , Javier Del Ser , Simon Walsh , Guang Yang

The reuse of historical clinical trial data has significant potential to accelerate medical research and drug development. However, interoperability challenges, particularly with missing medical codes, hinders effective data integration…

Machine Learning · Computer Science 2025-03-14 Nabeel Seedat , Caterina Tozzi , Andrea Hita Ardiaca , Mihaela van der Schaar , James Weatherall , Adam Taylor

Alzheimer's Disease (AD) is marked by significant inter-individual variability in its progression, complicating accurate prognosis and personalized care planning. This heterogeneity underscores the critical need for predictive models…

Machine Learning · Computer Science 2025-05-01 Gulsah Hancerliogullari Koksalmis , Bulent Soykan , Laura J. Brattain , Hsin-Hsiung Huang

The application of Artificial Intelligence (AI) in healthcare has been revolutionary, especially with the recent advancements in transformer-based Large Language Models (LLMs). However, the task of understanding unstructured electronic…

Computation and Language · Computer Science 2023-08-08 Shivani Shekhar , Simran Tiwari , T. C. Rensink , Ramy Eskander , Wael Salloum

Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang

Medical dialogue systems (MDS) enhance patient-physician communication, improve healthcare accessibility, and reduce costs. However, acquiring suitable data to train these systems poses significant challenges. Privacy concerns prevent the…

Computation and Language · Computer Science 2024-08-13 Trisha Das , Dina Albassam , Jimeng Sun

Large language models (LLMs) show promise for supporting clinicians in diagnostic communication by generating explanations and guidance for patients. Yet their ability to produce outputs that are both understandable and empathetic remains…

Computation and Language · Computer Science 2025-11-04 Jianzhou Yao , Shunchang Liu , Guillaume Drui , Rikard Pettersson , Alessandro Blasimme , Sara Kijewski

Structured data offers a sophisticated mechanism for the organization of information. Existing methodologies for the text-serialization of structured data in the context of large language models fail to adequately address the heterogeneity…

Computation and Language · Computer Science 2024-02-20 YiQiu Guo , Yuchen Yang , Ya Zhang , Yu Wang , Yanfeng Wang

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

United States healthcare systems are struggling to meet the growing demand for neurological care, particularly in Alzheimer's disease and related dementias (ADRD). Generative AI built on language models (LLMs) now enables agentic AI systems…

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