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Medical decision-making is a critical task, where errors can result in serious, potentially life-threatening consequences. While full automation remains challenging, hybrid frameworks that combine machine intelligence with human oversight…

Artificial Intelligence · Computer Science 2025-09-10 Debodeep Banerjee , Burcu Sayin , Stefano Teso , Andrea Passerini

Recent advancements in generative AI facilitate large-scale synthetic data generation for model evaluation. However, without targeted approaches, these datasets often lack the sociotechnical nuance required for sensitive domains. We…

AI-based persona simulation -- often referred to as digital twin simulation -- is increasingly used for market research, recommender systems, and social sciences. Despite their flexibility, large language models (LLMs) often exhibit…

Machine Learning · Computer Science 2026-04-10 Grace Jiarui Fan , Chengpiao Huang , Tianyi Peng , Kaizheng Wang , Yuhang Wu

The development of AI-assisted Early Intensive Behavioral Intervention (EIBI) for Autism Spectrum Disorder (ASD) is severely constrained by data scarcity. Furthermore, while Applied Behavior Analysis (ABA) serves as the gold standard for…

Machine Learning · Computer Science 2026-05-06 Junhong Lai , Shuzhong Lai , Yanhao Yu , Wanlin Chen , Chenyu Yan , Haifeng Li , Lin Yao , Yueming Wang

This survey reviews how large language models (LLMs) are transforming synthetic training data generation in both natural language and code domains. By producing artificial but task-relevant examples, these models can significantly augment…

Computation and Language · Computer Science 2025-11-21 Mihai Nadas , Laura Diosan , Andreea Tomescu

Despite strong performance in medical question-answering, the clinical adoption of Large Language Models (LLMs) is critically hampered by their opaque 'black-box' reasoning, limiting clinician trust. This challenge is compounded by the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Chao Ding , Mouxiao Bian , Pengcheng Chen , Hongliang Zhang , Tianbin Li , Lihao Liu , Jiayuan Chen , Zhuoran Li , Yabei Zhong , Yongqi Liu , Haiqing Huang , Dongming Shan , Junjun He , Jie Xu

An effective healthcare agent must be able to recall and reason over a patient's longitudinal medical history. However, the absence of datasets with realistic long-term dialogue timelines limits systematic evaluation. Real clinical text is…

Computation and Language · Computer Science 2026-05-20 Hebin Hu , Renke Dai , Ah-Hwee Tan , Yilin Kang

Synthetic data has the potential to improve the performance, training efficiency, and privacy of real training examples. Nevertheless, existing approaches for synthetic text generation are mostly heuristics and cannot generate…

Machine Learning · Computer Science 2025-06-10 Dang Nguyen , Zeman Li , Mohammadhossein Bateni , Vahab Mirrokni , Meisam Razaviyayn , Baharan Mirzasoleiman

Multimodal Large Language Models (MLLMs) have demonstrated remarkable potential in medical image analysis. However, their application in gastrointestinal endoscopy is currently hindered by two critical limitations: the misalignment between…

Computer Vision and Pattern Recognition · Computer Science 2026-04-10 Huan Zheng , Yucheng Zhou , Tianyi Yan , Dubing Chen , Hongbo Lu , Wenlong Liao , Tao He , Pai Peng , Jianbing Shen

Large Language Models (LLMs) such as GPT & Llama have demonstrated significant achievements in summarization tasks but struggle with factual inaccuracies, a critical issue in clinical NLP applications where errors could lead to serious…

Computation and Language · Computer Science 2024-10-04 Prakamya Mishra , Zonghai Yao , Parth Vashisht , Feiyun Ouyang , Beining Wang , Vidhi Dhaval Mody , Hong Yu

Synthetic healthcare data generation presents a viable approach to enhance data accessibility and support research by overcoming limitations associated with real-world medical datasets. However, ensuring fairness across protected attributes…

Machine Learning · Computer Science 2025-11-04 Sama Salarian , Yue Zhang , Swati Padhee , Srinivasan Parthasarathy

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Large Language Models (LLMs) generate realistic synthetic data but offer no guarantee that their outputs respect the causal mechanisms governing the target domain. We introduce CausalSynth, a framework that decouples causal structure…

Machine Learning · Computer Science 2026-05-19 Zehua Cheng , Wei Dai , Jiahao Sun , Thomas Lukasiewicz

Generative models have been showing potential for producing data in mass. This study explores the enhancement of clinical natural language processing performance by utilizing synthetic data generated from advanced language models. Promising…

Computation and Language · Computer Science 2024-03-29 Shan Chen , Jack Gallifant , Marco Guevara , Yanjun Gao , Majid Afshar , Timothy Miller , Dmitriy Dligach , Danielle S. Bitterman

Generative AI framework-based modeling and prediction of longitudinal human brain images offer an efficient mechanism to track neurodegenerative progression, essential for the assessment of diseases like Alzheimer's. Among the existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Ayantika Das , Keerthi Ram , Mohanasankar Sivaprakasam

Synthetic data is becoming increasingly integral in data-scarce fields such as medical imaging, serving as a substitute for real data. However, its inherent statistical characteristics can significantly impact downstream tasks, potentially…

Computer Vision and Pattern Recognition · Computer Science 2024-12-23 Krishan Agyakari Raja Babu , Rachana Sathish , Mrunal Pattanaik , Rahul Venkataramani

The use of synthetic data is recognized as a crucial step in the development of neural network-based Artificial Intelligence (AI) systems. While the methods for generating synthetic data for AI applications in other domains have a role in…

Artificial Intelligence · Computer Science 2023-03-17 Gary An , Chase Cockrell

Data is a crucial element in large language model (LLM) alignment. Recent studies have explored using LLMs for efficient data collection. However, LLM-generated data often suffers from quality issues, with underrepresented or absent aspects…

Computation and Language · Computer Science 2024-10-08 Fei Wang , Ninareh Mehrabi , Palash Goyal , Rahul Gupta , Kai-Wei Chang , Aram Galstyan

Early diagnosis of Alzheimer's Disease (AD) faces multiple data-related challenges, including high variability in patient data, limited access to specialized diagnostic tests, and overreliance on single-type indicators. These challenges are…

Quantitative Methods · Quantitative Biology 2025-03-05 Yizong Xing , Dhita Putri Pratama , Yuke Wang , Yufan Zhang , Brian E. Chapman

Within the evolving landscape of deep learning, the dilemma of data quantity and quality has been a long-standing problem. The recent advent of Large Language Models (LLMs) offers a data-centric solution to alleviate the limitations of…

Computation and Language · Computer Science 2024-06-24 Lin Long , Rui Wang , Ruixuan Xiao , Junbo Zhao , Xiao Ding , Gang Chen , Haobo Wang