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Recent advancements in large language models (LLMs) have achieved promising performances across various applications. Nonetheless, the ongoing challenge of integrating long-tail knowledge continues to impede the seamless adoption of LLMs in…

Computation and Language · Computer Science 2024-10-21 Dawei Li , Shu Yang , Zhen Tan , Jae Young Baik , Sukwon Yun , Joseph Lee , Aaron Chacko , Bojian Hou , Duy Duong-Tran , Ying Ding , Huan Liu , Li Shen , Tianlong Chen

Causal inference is essential for developing and evaluating medical interventions, yet real-world medical datasets are often difficult to access due to regulatory barriers. This makes synthetic data a potentially valuable asset that enables…

Machine Learning · Computer Science 2025-10-22 Harry Amad , Zhaozhi Qian , Dennis Frauen , Julianna Piskorz , Stefan Feuerriegel , Mihaela van der Schaar

The unstructured nature of clinical notes within electronic health records often conceals vital patient-related information, making it challenging to access or interpret. To uncover this hidden information, specialized Natural Language…

While hundreds of artificial intelligence (AI) algorithms are now approved or cleared by the US Food and Drugs Administration (FDA), many studies have shown inconsistent generalization or latent bias, particularly for underrepresented…

Computer Vision and Pattern Recognition · Computer Science 2023-08-25 Luke W. Sagers , James A. Diao , Luke Melas-Kyriazi , Matthew Groh , Pranav Rajpurkar , Adewole S. Adamson , Veronica Rotemberg , Roxana Daneshjou , Arjun K. Manrai

The recent boom of large language models (LLMs) has re-ignited the hope that artificial intelligence (AI) systems could aid medical diagnosis. Yet despite dazzling benchmark scores, LLM assistants have yet to deliver measurable improvements…

Artificial Intelligence · Computer Science 2025-07-03 Matthew JY Kang , Wenli Yang , Monica R Roberts , Byeong Ho Kang , Charles B Malpas

Psychiatric symptom identification on social media aims to infer fine-grained mental health symptoms from user-generated posts, allowing a detailed understanding of users' mental states. However, the construction of large-scale…

Computation and Language · Computer Science 2026-03-24 Migyeong Kang , Jihyun Kim , Hyolim Jeon , Sunwoo Hwang , Jihyun An , Yonghoon Kim , Haewoon Kwak , Jisun An , Jinyoung Han

Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Passively collected behavioral health data from ubiquitous sensors holds significant promise to provide mental health professionals insights from patient's daily lives; however, developing analysis tools to use this data in clinical…

The implementation of Artificial Intelligence (AI) in the healthcare industry has garnered considerable attention, attributable to its prospective enhancement of clinical outcomes, expansion of access to superior healthcare, cost reduction,…

Computation and Language · Computer Science 2024-08-23 Arindam Sett , Somaye Hashemifar , Mrunal Yadav , Yogesh Pandit , Mohsen Hejrati

The joint analysis of biomedical data in Alzheimer's Disease (AD) is important for better clinical diagnosis and to understand the relationship between biomarkers. However, jointly accounting for heterogeneous measures poses important…

Methodology · Statistics 2018-08-14 Luigi Antelmi , Nicholas Ayache , Philippe Robert , Marco Lorenzi

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Generating synthetic text addresses the challenge of data availability in privacy-sensitive domains such as healthcare. This study explores the applicability of synthetic data in real-world medical settings. We introduce MedSyn, a novel…

Computation and Language · Computer Science 2024-09-05 Gleb Kumichev , Pavel Blinov , Yulia Kuzkina , Vasily Goncharov , Galina Zubkova , Nikolai Zenovkin , Aleksei Goncharov , Andrey Savchenko

Since the COVID-19 pandemic, clinicians have seen a large and sustained influx in patient portal messages, significantly contributing to clinician burnout. To the best of our knowledge, there are no large-scale public patient portal…

Artificial Intelligence · Computer Science 2024-11-12 Joseph Gatto , Parker Seegmiller , Timothy E. Burdick , Sarah Masud Preum

Generative AI for automated glaucoma diagnostic report generation faces two predominant challenges: content redundancy in narrative outputs and inadequate highlighting of pathologically significant features including optic disc cupping,…

Computational Engineering, Finance, and Science · Computer Science 2025-10-14 Cheng Huang , Weizheng Xie , Zeyu Han , Tsengdar Lee , Karanjit Kooner , Jui-Ka Wang , Ning Zhang , Jia Zhang

Although many AI applications of interest require specialized multi-modal models, relevant data to train such models is inherently scarce or inaccessible. Filling these gaps with human annotators is prohibitively expensive, error-prone, and…

Artificial Intelligence · Computer Science 2026-04-01 Tim R. Davidson , Benoit Seguin , Enrico Bacis , Cesar Ilharco , Hamza Harkous

In the era of big data, access to abundant data is crucial for driving research forward. However, such data is often inaccessible due to privacy concerns or high costs, particularly in healthcare domain. Generating synthetic (tabular) data…

Machine Learning · Computer Science 2026-04-10 Yaobin Ling , Xiaoqian Jiang , Yejin Kim

Macro-aligned micro-records are crucial for credible simulations in social science and urban studies. For example, epidemic models are only reliable when individual-level mobility and contacts mirror real behavior, while aggregates match…

Machine Learning · Computer Science 2025-10-14 Yihong Tang , Menglin Kong , Junlin He , Tong Nie , Lijun Sun

Large Language Models (LLMs) offer a flexible means to generate synthetic tabular data, yet existing approaches often fail to preserve key causal parameters such as the average treatment effect (ATE). In this technical exploration, we first…

Machine Learning · Computer Science 2025-11-04 Dana Kim , Yichen Xu , Tiffany Lin

Synthetic data sets are used across linguistic domains and NLP tasks, particularly in scenarios where authentic data is limited (or even non-existent). One such domain is that of clinical (healthcare) contexts, where there exist significant…

Computation and Language · Computer Science 2026-03-17 Steven Bedrick , A. Seza Doğruöz , Sergiu Nisioi

An important issue impacting healthcare is a lack of available experts. Machine learning (ML) models could resolve this by aiding in diagnosing patients. However, creating datasets large enough to train these models is expensive. We…

Computation and Language · Computer Science 2024-05-14 Chancellor R. Woolsey , Prakash Bisht , Joshua Rothman , Gondy Leroy