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Large Language Models (LLMs) are widely used in sensitive domains, including healthcare, finance, and legal services, raising concerns about potential private information leaks during inference. Privacy extraction attacks, such as…

Cryptography and Security · Computer Science 2025-06-25 Jinwen He , Yiyang Lu , Zijin Lin , Kai Chen , Yue Zhao

This study explores the use of Large Language Models (LLMs) to analyze text comments from Reddit users, aiming to achieve two primary objectives: firstly, to pinpoint critical excerpts that support a predefined psychological assessment of…

Computation and Language · Computer Science 2024-02-07 Sergi Blanco-Cuaresma

Fine-tuning large language models (LLMs) for specific tasks introduces privacy risks, as models may inadvertently memorise and leak sensitive training data. While Differential Privacy (DP) offers a solution to mitigate these risks, it…

Machine Learning · Computer Science 2024-11-26 Olivia Ma , Jonathan Passerat-Palmbach , Dmitrii Usynin

Alignment is a key step in developing Large Language Models (LLMs) using human feedback to ensure adherence to human values and societal norms. Dependence on human feedback raises privacy concerns about how much a labeler's preferences may…

Machine Learning · Computer Science 2025-12-11 Noel Teku , Fengwei Tian , Payel Bhattacharjee , Souradip Chakraborty , Amrit Singh Bedi , Ravi Tandon

Radiology reports are often lengthy and unstructured, posing challenges for referring physicians to quickly identify critical imaging findings while increasing the risk of missed information. This retrospective study aimed to enhance…

Computation and Language · Computer Science 2025-06-05 Iryna Hartsock , Cyrillo Araujo , Les Folio , Ghulam Rasool

Recent advances in artificial intelligence, particularly large language models LLMs, have shown promising capabilities in transforming rare disease research. This survey paper explores the integration of LLMs in the analysis of rare…

Computation and Language · Computer Science 2025-05-26 Valentina Carbonari , Pierangelo Veltri , Pietro Hiram Guzzi

This paper proposes one of the first clinical applications of multimodal large language models (LLMs) as an assistant for radiologists to check errors in their reports. We created an evaluation dataset from real-world radiology datasets…

Computation and Language · Computer Science 2024-03-05 Jinge Wu , Yunsoo Kim , Eva C. Keller , Jamie Chow , Adam P. Levine , Nikolas Pontikos , Zina Ibrahim , Paul Taylor , Michelle C. Williams , Honghan Wu

Recent advancements in pre-trained large language models (LLMs) have significantly influenced various domains. Adapting these models for specific tasks often involves fine-tuning (FT) with private, domain-specific data. However, privacy…

Cryptography and Security · Computer Science 2024-12-11 Guanzhong Chen , Zhenghan Qin , Mingxin Yang , Yajie Zhou , Tao Fan , Tianyu Du , Zenglin Xu

Fine-tuning unlocks large language models (LLMs) for specialized applications, but its high computational cost often puts it out of reach for resource-constrained organizations. While cloud platforms could provide the needed resources, data…

Cryptography and Security · Computer Science 2026-04-28 Zihan Liu , Yizhen Wang , Rui Wang , Xiu Tang , Sai Wu

Large Language Models (LLMs) have become integral to numerous domains, significantly advancing applications in data management, mining, and analysis. Their profound capabilities in processing and interpreting complex language data, however,…

Cryptography and Security · Computer Science 2024-09-09 Qinbin Li , Junyuan Hong , Chulin Xie , Jeffrey Tan , Rachel Xin , Junyi Hou , Xavier Yin , Zhun Wang , Dan Hendrycks , Zhangyang Wang , Bo Li , Bingsheng He , Dawn Song

As large language models (LLMs) become progressively more embedded in clinical decision-support, documentation, and patient-information systems, ensuring their privacy and trustworthiness has emerged as an imperative challenge for the…

Cryptography and Security · Computer Science 2025-10-22 Alexander Nemecek , Zebin Yun , Zahra Rahmani , Yaniv Harel , Vipin Chaudhary , Mahmood Sharif , Erman Ayday

Retrieval-augmented generation (RAG) enhances large language models (LLMs) by retrieving documents from an external corpus at inference time. When this corpus contains sensitive information, however, unprotected RAG systems are at risk of…

Machine Learning · Computer Science 2025-11-12 Ruihan Wu , Erchi Wang , Zhiyuan Zhang , Yu-Xiang Wang

Prominent Large Language Model (LLM) services from providers like OpenAI and Google excel at general tasks but often underperform on domain-specific applications. Current customization services for these LLMs typically require users to…

Machine Learning · Computer Science 2026-02-17 Zhaomin Wu , Jizhou Guo , Junyi Hou , Bingsheng He , Lixin Fan , Qiang Yang

The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, and a…

Computation and Language · Computer Science 2023-08-08 Jiayi Yuan , Ruixiang Tang , Xiaoqian Jiang , Xia Hu

Protecting patient privacy in clinical narratives is essential for enabling secondary use of healthcare data under regulations such as GDPR and HIPAA. While manual de-identification remains the gold standard, it is costly and slow,…

Cryptography and Security · Computer Science 2026-04-24 Michele Miranda , Xinlan Yan , Nishant Mishra , Rachel Murphy , Ameen Abu-Hanna , Sébastien Bratières , Iacer Calixto

The proliferation of Large Language Models (LLMs) has driven considerable interest in fine-tuning them with domain-specific data to create specialized language models. Nevertheless, such domain-specific fine-tuning data often contains…

Computation and Language · Computer Science 2024-10-29 Yijia Xiao , Yiqiao Jin , Yushi Bai , Yue Wu , Xianjun Yang , Xiao Luo , Wenchao Yu , Xujiang Zhao , Yanchi Liu , Quanquan Gu , Haifeng Chen , Wei Wang , Wei Cheng

Aligning Large Language Models (LLMs) with human values and away from undesirable behaviors (such as hallucination) has become increasingly important. Recently, steering LLMs towards a desired behavior via activation editing has emerged as…

Computation and Language · Computer Science 2025-03-21 Anmol Goel , Yaxi Hu , Iryna Gurevych , Amartya Sanyal

Machine learning (ML) models frequently rely on training data that may include sensitive or personal information, raising substantial privacy concerns. Legislative frameworks such as the General Data Protection Regulation (GDPR) and the…

Machine Learning · Computer Science 2024-12-31 Md Mahadi Hasan Nahid , Sadid Bin Hasan

With the widespread application of large language models (LLMs), user privacy protection has become a significant research topic. Existing privacy preference modeling methods often rely on large-scale user data, making effective privacy…

Cryptography and Security · Computer Science 2025-05-13 Haowei Yang , Qingyi Lu , Yang Wang , Sibei Liu , Jiayun Zheng , Ao Xiang

Graphs offer unique insights into relationships between entities, complementing data modalities like text and images and enabling AI models to extend their capabilities beyond traditional tasks. However, learning from graphs often involves…

Machine Learning · Computer Science 2025-09-18 Haoteng Yin , Rongzhe Wei , Eli Chien , Pan Li