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Clinical free-text data offers immense potential to improve population health research such as richer phenotyping, symptom tracking, and contextual understanding of patient care. However, these data present significant privacy risks due to…

Backgrounds: Information extraction (IE) is critical in clinical natural language processing (NLP). While large language models (LLMs) excel on generative tasks, their performance on extractive tasks remains debated. Methods: We…

Named Entity Recognition (NER) has been mostly studied in the context of written text. Specifically, NER is an important step in de-identification (de-ID) of medical records, many of which are recorded conversations between a patient and a…

Computation and Language · Computer Science 2019-05-07 Ido Cohn , Itay Laish , Genady Beryozkin , Gang Li , Izhak Shafran , Idan Szpektor , Tzvika Hartman , Avinatan Hassidim , Yossi Matias

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

Exploiting natural language processing in the clinical domain requires de-identification, i.e., anonymization of personal information in texts. However, current research considers de-identification and downstream tasks, such as concept…

Computation and Language · Computer Science 2020-05-20 Lukas Lange , Heike Adel , Jannik Strötgen

Deep learning models have been shown to be susceptible to adversarial attacks with visually imperceptible perturbations. Even this poses a serious security challenge for the localization of self-driving cars, there has been very little…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Yizhen Lao , Yu Zhang , Ziting Wang , Chengbo Wang , Yifei Xue , Wanpeng Shao

Large Transformers pretrained over clinical notes from Electronic Health Records (EHR) have afforded substantial gains in performance on predictive clinical tasks. The cost of training such models (and the necessity of data access to do so)…

Computation and Language · Computer Science 2021-04-26 Eric Lehman , Sarthak Jain , Karl Pichotta , Yoav Goldberg , Byron C. Wallace

We hypothesize that large language models (LLMs) based on the transformer architecture can enable automated detection of clinical phenotype terms, including terms not documented in the HPO. In this study, we developed two types of models:…

Quantitative Methods · Quantitative Biology 2023-11-10 Jingye Yang , Cong Liu , Wendy Deng , Da Wu , Chunhua Weng , Yunyun Zhou , Kai Wang

This paper conducts a comprehensive investigation into applying large language models, particularly on BioBERT, in healthcare. It begins with thoroughly examining previous natural language processing (NLP) approaches in healthcare, shedding…

Artificial Intelligence · Computer Science 2023-10-13 Shyni Sharaf , V. S. Anoop

Major depressive disorder (MDD) is a prevalent psychiatric disorder that is associated with significant healthcare burden worldwide. Phenotyping of MDD can help early diagnosis and consequently may have significant advantages in patient…

Biomedical named entity recognition (NER) is a fundamental task in text mining of medical documents and has many applications. Deep learning based approaches to this task have been gaining increasing attention in recent years as their…

Computation and Language · Computer Science 2018-08-16 Devendra Singh Sachan , Pengtao Xie , Mrinmaya Sachan , Eric P Xing

Protecting patient data privacy is a critical concern when deploying machine learning algorithms in healthcare. Differential privacy (DP) is a common method for preserving privacy in such settings and, in this work, we examine two key…

Machine Learning · Computer Science 2024-12-10 Ali Dadsetan , Dorsa Soleymani , Xijie Zeng , Frank Rudzicz

In the era of big data, there is an increasing need for healthcare providers, communities, and researchers to share data and collaborate to improve health outcomes, generate valuable insights, and advance research. The Health Insurance…

Cryptography and Security · Computer Science 2023-05-23 Kai Zhang , Xiaoqian Jiang

Large Language Models (LLMs) are increasingly adopted across domains such as education, healthcare, and finance. In healthcare, LLMs support tasks including disease diagnosis, abnormality classification, and clinical decision-making. Among…

Cryptography and Security · Computer Science 2026-03-31 Payel Bhattacharjee , Fengwei Tian , Geoffrey D. Rubin , Joseph Y. Lo , Nirav Merchant , Heidi Hanson , John Gounley , Ravi Tandon

This study evaluated the effect of BioBERT in medical text processing for the task of medical named entity recognition. Through comparative experiments with models such as BERT, ClinicalBERT, SciBERT, and BlueBERT, the results showed that…

Computation and Language · Computer Science 2024-12-12 Jiacheng Hu , Runyuan Bao , Yang Lin , Hanchao Zhang , Yanlin Xiang

As large language models (LLMs) become progressively more embedded in clinical decision-support, documentation, and patient-information systems, ensuring their privacy and trustworthiness has emerged as an imperative challenge for the…

Cryptography and Security · Computer Science 2025-10-22 Alexander Nemecek , Zebin Yun , Zahra Rahmani , Yaniv Harel , Vipin Chaudhary , Mahmood Sharif , Erman Ayday

Deep learning (DL)-based solutions have been extensively researched in the medical domain in recent years, enhancing the efficacy of diagnosis, planning, and treatment. Since the usage of health-related data is strictly regulated,…

Cryptography and Security · Computer Science 2023-09-01 Andreea Bianca Popescu , Cosmin Ioan Nita , Ioana Antonia Taca , Anamaria Vizitiu , Lucian Mihai Itu

Deep learning has been widely used in medical image segmentation and other aspects. However, the performance of existing medical image segmentation models has been limited by the challenge of obtaining sufficient high-quality labeled data…

Computer Vision and Pattern Recognition · Computer Science 2023-06-28 Zihan Li , Yunxiang Li , Qingde Li , Puyang Wang , Dazhou Guo , Le Lu , Dakai Jin , You Zhang , Qingqi Hong

The detection of Personally Identifiable Information (PII) is critical for privacy compliance but remains challenging in low-resource languages due to linguistic diversity and limited annotated data. We present RECAP, a hybrid framework…

Image de-identification is essential for the public sharing of medical images, particularly in the widely used Digital Imaging and Communications in Medicine (DICOM) format as required by various regulations and standards, including Health…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Hongzhu Jiang , Sihan Xie , Zhiyu Wan
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