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Weakly supervised whole slide image classification is a key task in computational pathology, which involves predicting a slide-level label from a set of image patches constituting the slide. Constructing models to solve this task involves…

Recent breakthroughs in self-supervised learning have enabled the use of large unlabeled datasets to train visual foundation models that can generalize to a variety of downstream tasks. While this training paradigm is well suited for the…

Pathology foundation models (PFMs) have demonstrated strong representational capabilities through self-supervised pre-training on large-scale, unannotated histopathology image datasets. However, their diverse yet opaque pretraining…

Computer Vision and Pattern Recognition · Computer Science 2025-09-15 Yuxiang Xiao , Yang Hu , Bin Li , Tianyang Zhang , Zexi Li , Huazhu Fu , Jens Rittscher , Kaixiang Yang

Vision foundation models (FMs) are accelerating the development of digital pathology algorithms and transforming biomedical research. These models learn, in a self-supervised manner, to represent histological features in highly…

Pathology foundation models (FMs) have driven significant progress in computational pathology. However, these high-performing models can easily exceed a billion parameters and produce high-dimensional embeddings, thus limiting their…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Christian Grashei , Christian Brechenmacher , Rao Muhammad Umer , Jingsong Liu , Carsten Marr , Ewa Szczurek , Peter J. Schüffler

Foundation models in medical imaging have shown promising label efficiency, achieving high performance on downstream tasks using only a fraction of the annotated data otherwise required. In this study, we evaluate this potential in the…

The emergence of foundation models in computational pathology has transformed histopathological image analysis, with whole slide imaging (WSI) diagnosis being a core application. Traditionally, weakly supervised fine-tuning via multiple…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 Jiawen Li , Jiali Hu , Qiehe Sun , Renao Yan , Minxi Ouyang , Tian Guan , Anjia Han , Chao He , Yonghong He

Foundation models leverage large-scale pretraining to capture extensive knowledge, demonstrating generalization in a wide range of language tasks. By comparison, vision foundation models (VFMs) often exhibit uneven improvements across…

Computer Vision and Pattern Recognition · Computer Science 2026-01-23 Shiqi Huang , Yipei Wang , Natasha Thorley , Alexander Ng , Shaheer Saeed , Mark Emberton , Shonit Punwani , Veeru Kasivisvanathan , Dean Barratt , Daniel Alexander , Yipeng Hu

Foundation models in computational pathology promise to unlock the development of new clinical decision support systems and models for precision medicine. However, there is a mismatch between most clinical analysis, which is defined at the…

Promptable segmentation foundation models have emerged as a transformative approach to addressing the diverse needs in medical images, but most existing models require expensive computing, posing a big barrier to their adoption in clinical…

Discriminative classifiers have become a foundational tool in deep learning for medical imaging, excelling at learning separable features of complex data distributions. However, these models often need careful design, augmentation, and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Gian Mario Favero , Parham Saremi , Emily Kaczmarek , Brennan Nichyporuk , Tal Arbel

Prostate Cancer (PCa) is a prevalent disease among men, and multi-parametric MRIs offer a non-invasive method for its detection. While MRI-based deep learning solutions have shown promise in supporting PCa diagnosis, acquiring sufficient…

Image and Video Processing · Electrical Eng. & Systems 2024-06-04 Meng Zhou , Amoon Jamzad , Jason Izard , Alexandre Menard , Robert Siemens , Parvin Mousavi

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Wearable foundation models (WFMs), trained on large volumes of data collected by affordable, always-on devices, have demonstrated strong performance on short-term, well-defined health monitoring tasks, including activity recognition,…

Machine Learning · Computer Science 2026-03-23 Yu Yvonne Wu , Yuwei Zhang , Hyungjun Yoon , Ting Dang , Dimitris Spathis , Tong Xia , Qiang Yang , Jing Han , Dong Ma , Sung-Ju Lee , Cecilia Mascolo

Whole slide image (WSI) analysis has emerged as an increasingly essential technique in computational pathology. Recent advances in the pathology foundation models (FMs) have demonstrated significant advantages in deriving meaningful…

Computer Vision and Pattern Recognition · Computer Science 2025-11-21 Zhidong Yang , Xiuhui Shi , Wei Ba , Zhigang Song , Haijing Luan , Taiyuan Hu , Senlin Lin , Jiguang Wang , Shaohua Kevin Zhou , Rui Yan

Current multi-instance learning algorithms for pathology image analysis often require a substantial number of Whole Slide Images for effective training but exhibit suboptimal performance in scenarios with limited learning data. In clinical…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Linhao Qu , Dingkang Yang , Dan Huang , Qinhao Guo , Rongkui Luo , Shaoting Zhang , Xiaosong Wang

Background and objective: Cell-level pathological image analysis requires working with extremely small image patches (40x40 pixels), far below standard ImageNet resolutions. It remains unclear whether modern deep learning architectures and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Hiroki Kagiyama , Toru Nagasaka , Yukari Adachi , Takaaki Tachibana , Ryota Ito , Mitsugu Fujita , Kimihiro Yamashita , Yoshihiro Kakeji

Osteosarcoma, the most common primary bone cancer, often requires accurate necrosis assessment from whole slide images (WSIs) for effective treatment planning and prognosis. However, manual assessments are subjective and prone to…

Computer Vision and Pattern Recognition · Computer Science 2025-01-06 Manh Duong Nguyen , Dac Thai Nguyen , Trung Viet Nguyen , Homi Yamada , Huy Hieu Pham , Phi Le Nguyen

Medical image segmentation is crucial for clinical diagnosis. The Segmentation Anything Model (SAM) serves as a powerful foundation model for visual segmentation and can be adapted for medical image segmentation. However, medical imaging…

Image and Video Processing · Electrical Eng. & Systems 2024-11-07 Yuxi Liu , Guibo Luo , Yuesheng Zhu

Transformer-based foundation models (FMs) have recently demonstrated remarkable performance in medical image segmentation. However, scaling these models is challenging due to the limited size of medical image datasets within isolated…

Image and Video Processing · Electrical Eng. & Systems 2025-03-20 Yumin Zhang , Yan Gao , Haoran Duan , Hanqing Guo , Tejal Shah , Rajiv Ranjan , Bo Wei