Osteosarcoma, the most common primary bone cancer, often requires accurate necrosis assessment from whole slide images (WSIs) for effective treatment planning and prognosis. However, manual assessments are subjective and prone to variability. In response, we introduce FDDM, a novel framework bridging the gap between patch classification and region-based segmentation. FDDM operates in two stages: patch-based classification, followed by region-based refinement, enabling cross-patch information intergation. Leveraging a newly curated dataset of osteosarcoma images, FDDM demonstrates superior segmentation performance, achieving up to a 10% improvement mIOU and a 32.12% enhancement in necrosis rate estimation over state-of-the-art methods. This framework sets a new benchmark in osteosarcoma assessment, highlighting the potential of foundation models and diffusion-based refinements in complex medical imaging tasks.
@article{arxiv.2501.01932,
title = {Bridging Classification and Segmentation in Osteosarcoma Assessment via Foundation and Discrete Diffusion Models},
author = {Manh Duong Nguyen and Dac Thai Nguyen and Trung Viet Nguyen and Homi Yamada and Huy Hieu Pham and Phi Le Nguyen},
journal= {arXiv preprint arXiv:2501.01932},
year = {2025}
}
Comments
Accepted for presentation at the 2025 IEEE International Symposium on Biomedical Imaging (ISBI 2025)