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Foundation models (FMs) have achieved remarkable success across a wide range of applications, from image classification to natural langurage processing, but pose significant challenges for deployment at edge. This has sparked growing…

Machine Learning · Computer Science 2025-07-17 Muhammad Azlan Qazi , Alexandros Iosifidis , Qi Zhang

Foundation models (FMs) are changing the way medical images are analyzed by learning from large collections of unlabeled data. Instead of relying on manually annotated examples, FMs are pre-trained to learn general-purpose visual features…

Artificial intelligence foundation models are increasingly deployed for prostate cancer Gleason grading, where GP3/GP4 distinction directly impacts treatment decisions. However, these models may achieve high validation accuracy by learning…

Computer Vision and Pattern Recognition · Computer Science 2025-12-18 Joshua L. Ebbert , Dennis Della Corte

Most state-of-the-art techniques for medical image segmentation rely on deep-learning models. These models, however, are often trained on narrowly-defined tasks in a supervised fashion, which requires expensive labeled datasets. Recent…

Image and Video Processing · Electrical Eng. & Systems 2023-10-04 Heejong Kim , Victor Ion Butoi , Adrian V. Dalca , Daniel J. A. Margolis , Mert R. Sabuncu

Foundation models have emerged as a powerful paradigm in computational pathology (CPath), enabling scalable and generalizable analysis of histopathological images. While early developments centered on uni-modal models trained solely on…

Computer Vision and Pattern Recognition · Computer Science 2025-03-21 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Xiaohui Chen , Yi He , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Foundation models are reshaping computational pathology by enabling transfer learning, where models pre-trained on vast datasets can be adapted for downstream diagnostic, prognostic, and therapeutic response tasks. Despite these advances,…

Foundation models (FM) have transformed computational pathology but remain computationally prohibitive for clinical deployment due to their massive parameter counts and high-magnification processing requirements. Here, we introduce XMAG, a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ziyu Su , Abdul Rehman Akbar , Usama Sajjad , Anil V. Parwani , Muhammad Khalid Khan Niazi

Radiomics-based machine learning models show promise for clinical decision support but are vulnerable to distribution shifts caused by variations in imaging protocols, positioning, and segmentation. This study systematically investigates…

Machine Learning · Computer Science 2025-10-30 Sarmad Ahmad Khan , Simon Bernatz , Zahra Moslehi , Florian Buettner

Foundation models are a current focus of attention in both industry and academia. While they have shown their capabilities in a variety of tasks, in-depth research is required to determine their robustness to distribution shift when used as…

Computation and Language · Computer Science 2023-12-12 Xiruo Ding , Zhecheng Sheng , Brian Hur , Feng Chen , Serguei V. S. Pakhomov , Trevor Cohen

The rapid proliferation of open-source medical foundation models (FMs) raises a practical question: how well do their pre-trained representations transfer to clinically relevant but data-scarce classification tasks? Particularly in CT-based…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Hartmut Häntze , Sarah de Boer , Myrthe Buser , Alessa Hering , Bram van Ginneken , Mathias Prokop , Jawed Nawabi , Sebastian Ziegelmayer , Lisa Adams , Keno Bressem

Foundation models (FMs) have demonstrated strong transferability across medical imaging tasks, yet their clinical utility depends critically on how pretrained representations are adapted to domain-specific data, supervision regimes, and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Karma Phuntsho , Abdullah , Kyungmi Lee , Ickjai Lee , Euijoon Ahn

We present PDE-FM, a modular foundation model for physics-informed machine learning that unifies spatial, spectral, and temporal reasoning across heterogeneous partial differential equation (PDE) systems. PDE-FM combines spatial-spectral…

Machine Learning · Computer Science 2025-12-01 Eduardo Soares , Emilio Vital Brazil , Victor Shirasuna , Breno W. S. R. de Carvalho , Cristiano Malossi

Pathology foundation models (PFMs), as large-scale pre-trained models tailored for computational pathology, have significantly advanced a wide range of applications. Their ability to leverage prior knowledge from massive datasets has…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Weiping Lin , Shen Liu , Runchen Zhu , Yixuan Lin , Baoshun Wang , Liansheng Wang

Recent advancements in artificial intelligence (AI), particularly foundation models (FMs), have revolutionized medical image analysis, demonstrating strong zero- and few-shot performance across diverse medical imaging tasks, from…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Praveenbalaji Rajendran , Mojtaba Safari , Wenfeng He , Mingzhe Hu , Shansong Wang , Jun Zhou , Xiaofeng Yang

Graph foundation models (GFM) aim to acquire transferable knowledge by pre-training on diverse graphs, which can be adapted to various downstream tasks. However, domain shift in graphs is inherently two-dimensional: graphs differ not only…

Computation and Language · Computer Science 2026-03-12 Xingtong Yu , Shenghua Ye , Ruijuan Liang , Chang Zhou , Hong Cheng , Xinming Zhang , Yuan Fang

Cancer research is increasingly driven by the integration of diverse data modalities, spanning from genomics and proteomics to imaging and clinical factors. However, extracting actionable insights from these vast and heterogeneous datasets…

Prostate cancer being one of the frequently diagnosed malignancy in men, the rising demand for biopsies places a severe workload on pathologists. The grading procedure is tedious and subjective, motivating the development of automated…

Computer Vision and Pattern Recognition · Computer Science 2026-03-06 Riddhasree Bhattacharyya , Pallabi Dutta , Sushmita Mitra

Foundation models have substantially advanced computational pathology by learning transferable visual representations from large histological datasets, yet their performance varies widely across tasks due to differences in training data…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Wenhui Lei , Yusheng Tan , Anqi Li , Hanyu Chen , Hengrui Tian , Ruiying Li , Zhengqun Jiang , Fang Yan , Xiaofan Zhang , Shaoting Zhang

Pathology image segmentation across multiple centers encounters significant challenges due to diverse sources of heterogeneity including imaging modalities, organs, and scanning equipment, whose variability brings representation bias and…

Computer Vision and Pattern Recognition · Computer Science 2025-05-29 Yuan Zhang , Feng Chen , Yaolei Qi , Guanyu Yang , Huazhu Fu

Digital pathology has significantly advanced disease detection and pathologist efficiency through the analysis of gigapixel whole-slide images (WSI). In this process, WSIs are first divided into patches, for which a feature extractor model…

Computer Vision and Pattern Recognition · Computer Science 2024-08-05 Gustav Bredell , Marcel Fischer , Przemyslaw Szostak , Samaneh Abbasi-Sureshjani , Alvaro Gomariz