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The whole slide image (WSI) classification is often formulated as a multiple instance learning (MIL) problem. Since the positive tissue is only a small fraction of the gigapixel WSI, existing MIL methods intuitively focus on identifying…

Computer Vision and Pattern Recognition · Computer Science 2023-12-22 Wenhao Tang , Sheng Huang , Xiaoxian Zhang , Fengtao Zhou , Yi Zhang , Bo Liu

Whole slide image (WSI) refers to a type of high-resolution scanned tissue image, which is extensively employed in computer-assisted diagnosis (CAD). The extremely high resolution and limited availability of region-level annotations make…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Ruijie Zhang , Qiaozhe Zhang , Yingzhuang Liu , Hao Xin , Yan Liu , Xinggang Wang

Deep learning (DL) models for disease classification or segmentation from medical images are increasingly trained using transfer learning (TL) from unrelated natural world images. However, shortcomings and utility of TL for specialized…

Machine Learning · Statistics 2021-11-11 Sambuddha Ghosal , Pratik Shah

Semantic segmentation research has recently witnessed rapid progress, but many leading methods are unable to identify object instances. In this paper, we present Multi-task Network Cascades for instance-aware semantic segmentation. Our…

Computer Vision and Pattern Recognition · Computer Science 2015-12-15 Jifeng Dai , Kaiming He , Jian Sun

Uncertainty quantification (UQ) has become critical for evaluating the reliability of artificial intelligence systems, especially in medical image segmentation. This study addresses the interpretability of instance-wise uncertainty values…

We propose a new and, arguably, a very simple reduction of instance segmentation to semantic segmentation. This reduction allows to train feed-forward non-recurrent deep instance segmentation systems in an end-to-end fashion using…

Computer Vision and Pattern Recognition · Computer Science 2018-07-27 Victor Kulikov , Victor Yurchenko , Victor Lempitsky

In the last few years, deep learning classifiers have shown promising results in image-based medical diagnosis. However, interpreting the outputs of these models remains a challenge. In cancer diagnosis, interpretability can be achieved by…

Computer Vision and Pattern Recognition · Computer Science 2021-06-16 Kangning Liu , Yiqiu Shen , Nan Wu , Jakub Chłędowski , Carlos Fernandez-Granda , Krzysztof J. Geras

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Multiple instance learning (MIL) is a key algorithm for classification of whole slide images (WSI). Histology WSIs can have billions of pixels, which create enormous computational and annotation challenges. Typically, such images are…

Image and Video Processing · Electrical Eng. & Systems 2021-11-03 Andriy Myronenko , Ziyue Xu , Dong Yang , Holger Roth , Daguang Xu

Interpretability in machine learning models is important in high-stakes decisions, such as whether to order a biopsy based on a mammographic exam. Mammography poses important challenges that are not present in other computer vision tasks:…

Machine Learning · Computer Science 2021-03-24 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

In high-stakes applications of machine learning models, interpretability methods provide guarantees that models are right for the right reasons. In medical imaging, saliency maps have become the standard tool for determining whether a…

Computer Vision and Pattern Recognition · Computer Science 2019-12-05 Jacob Pfau , Albert T. Young , Maria L. Wei , Michael J. Keiser

The accurate understanding of ischemic stroke lesions is critical for efficient therapy and prognosis of stroke patients. Magnetic resonance imaging (MRI) is sensitive to acute ischemic stroke and is a common diagnostic method for stroke.…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 R. P. Chowdhury , T. Rahman

It has been long debated that eXplainable AI (XAI) is an important topic, but it lacks rigorous definition and fair metrics. In this paper, we briefly summarize the status quo of the metrics, along with an exhaustive experimental study…

Artificial Intelligence · Computer Science 2021-01-01 Xiao-Hui Li , Yuhan Shi , Haoyang Li , Wei Bai , Yuanwei Song , Caleb Chen Cao , Lei Chen

The field of computer vision is undergoing a paradigm shift toward large-scale foundation model pre-training via self-supervised learning (SSL). Leveraging large volumes of unlabeled brain MRI data, such models can learn anatomical priors…

Image and Video Processing · Electrical Eng. & Systems 2026-01-15 Petros Koutsouvelis , Matej Gazda , Leroy Volmer , Sina Amirrajab , Kamil Barbierik , Branislav Setlak , Jakub Gazda , Peter Drotar

The remarkable success of deep learning has prompted interest in its application to medical imaging diagnosis. Even though state-of-the-art deep learning models have achieved human-level accuracy on the classification of different types of…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Cristiano Patrício , João C. Neves , Luís F. Teixeira

Hyperspectral imaging (HSI) shows great promise for surgical applications, offering detailed insights into biological tissue differences beyond what the naked eye can perceive. Refined labelling efforts are underway to train vision systems…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Junwen Wang , Oscar Maccormac , William Rochford , Aaron Kujawa , Jonathan Shapey , Tom Vercauteren

Amidst the rapid expansion of Machine Learning (ML) and Large Language Models (LLMs), understanding the semantics within their mechanisms is vital. Causal analyses define semantics, while gradient-based methods are essential to eXplainable…

Artificial Intelligence · Computer Science 2024-03-26 Yosuke Miyanishi , Minh Le Nguyen

Bag-based Multiple Instance Learning (MIL) approaches have emerged as the mainstream methodology for Whole Slide Image (WSI) classification. However, most existing methods adopt a segmented training strategy, which first extracts features…

Computer Vision and Pattern Recognition · Computer Science 2025-03-13 Jiangping Wen , Jinyu Wen , Meie Fang

There have been remarkable improvements in the semantic labelling task in the recent years. However, the state of the art methods rely on large-scale pixel-level annotations. This paper studies the problem of training a pixel-wise semantic…

Computer Vision and Pattern Recognition · Computer Science 2017-07-17 Seong Joon Oh , Rodrigo Benenson , Anna Khoreva , Zeynep Akata , Mario Fritz , Bernt Schiele

Malignant lymphoma subtype classification directly impacts treatment strategies and patient outcomes, necessitating classification models that achieve both high accuracy and sufficient explainability. This study proposes a novel explainable…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Daiki Nishiyama , Hiroaki Miyoshi , Noriaki Hashimoto , Koichi Ohshima , Hidekata Hontani , Ichiro Takeuchi , Jun Sakuma
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