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Multiple Instance Learning (MIL) has emerged as the best solution for Whole Slide Image (WSI) classification. It consists of dividing each slide into patches, which are treated as a bag of instances labeled with a global label. MIL includes…

Computer Vision and Pattern Recognition · Computer Science 2025-05-05 Ali Mammadov , Loic Le Folgoc , Julien Adam , Anne Buronfosse , Gilles Hayem , Guillaume Hocquet , Pietro Gori

Lesions that appear hyperintense in both Fluid Attenuated Inversion Recovery (FLAIR) and T2-weighted magnetic resonance images (MRIs) of the human brain are common in the brains of the elderly population and may be caused by ischemia or…

Image and Video Processing · Electrical Eng. & Systems 2021-01-20 Hans E. Atlason , Askell Love , Sigurdur Sigurdsson , Vilmundur Gudnason , Lotta M. Ellingsen

We present a method for skin lesion segmentation for the ISIC 2017 Skin Lesion Segmentation Challenge. Our approach is based on a Fully Convolutional Network architecture which is trained end to end, from scratch, on a limited dataset. Our…

Computer Vision and Pattern Recognition · Computer Science 2017-03-16 Dhanesh Ramachandram , Terrance DeVries

Medical image segmentation models are typically supervised by expert annotations at the pixel-level, which can be expensive to acquire. In this work, we propose a method that combines the high quality of pixel-level expert annotations with…

Computer Vision and Pattern Recognition · Computer Science 2021-05-18 Soham Gadgil , Mark Endo , Emily Wen , Andrew Y. Ng , Pranav Rajpurkar

eXplainable Artificial Intelligence (XAI) has emerged as an essential requirement when dealing with mission-critical applications, ensuring transparency and interpretability of the employed black box AI models. The significance of XAI spans…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 Hossein Shreim , Abdul Karim Gizzini , Ali J. Ghandour

Malignant brain tumors have become an aggressive and dangerous disease that leads to death worldwide.Multi-modal MRI data is crucial for accurate brain tumor segmentation, but missing modalities common in clinical practice can severely…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Bingcang Huang , Kai Chen , Lin Gu , Zhe Wang , Sai Wu , Chang Yao

Recently, many methods to interpret and visualize deep neural network predictions have been proposed and significant progress has been made. However, a more class-discriminative and visually pleasing explanation is required. Thus, this…

Computer Vision and Pattern Recognition · Computer Science 2020-01-06 Dasom Seo , Kanghan Oh , Il-Seok Oh

Deep learning-based medical image analysis faces a significant barrier due to the lack of interpretability. Conventional explainable AI (XAI) techniques, such as Grad-CAM and SHAP, often highlight regions outside clinical interests. To…

Image and Video Processing · Electrical Eng. & Systems 2025-02-17 Yuhao Zhang , Mingcheng Zhu , Zhiyao Luo

Multiple instance learning (MIL) has emerged as the dominant paradigm for whole slide image (WSI) analysis in computational pathology, achieving strong diagnostic performance through patch-level feature aggregation. However, existing MIL…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Yiran Song , Yikai Zhang , Shuang Zhou , Guojun Xiong , Xiaofeng Yang , Nian Wang , Fenglong Ma , Rui Zhang , Mingquan Lin

Consistent surgical instrument segmentation is critical for automation in robot-assisted surgery. Yet, existing methods only treat instrument-level instance segmentation (IIS) or part-level semantic segmentation (PSS) separately, without…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Meng Wei , Charlie Budd , Oluwatosin Alabi , Miaojing Shi , Tom Vercauteren

Deep Learning has shown outstanding results in computer vision tasks; healthcare is no exception. However, there is no straightforward way to expose the decision-making process of DL models. Good accuracy is not enough for skin cancer…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Rosa Y. G. Paccotacya-Yanque , Alceu Bissoto , Sandra Avila

LIME (Local Interpretable Model-agnostic Explanations) is a popular XAI framework for unraveling decision-making processes in vision machine-learning models. The technique utilizes image segmentation methods to identify fixed regions for…

Computer Vision and Pattern Recognition · Computer Science 2025-09-22 Patrick Knab , Sascha Marton , Christian Bartelt

Acute stroke lesion segmentation tasks are of great clinical interest as they can help doctors make better informed treatment decisions. Magnetic resonance imaging (MRI) is time demanding but can provide images that are considered gold…

Computer Vision and Pattern Recognition · Computer Science 2019-04-25 Albert Clèrigues , Sergi Valverde , Jose Bernal , Jordi Freixenet , Arnau Oliver , Xavier Lladó

Instance segmentation of surgical instruments is a long-standing research problem, crucial for the development of many applications for computer-assisted surgery. This problem is commonly tackled via fully-supervised training of deep…

Computer Vision and Pattern Recognition · Computer Science 2023-09-06 Luca Sestini , Benoit Rosa , Elena De Momi , Giancarlo Ferrigno , Nicolas Padoy

Instance segmentation is critical in biomedical imaging to accurately distinguish individual objects like cells, which often overlap and vary in size. Recent query-based methods, where object queries guide segmentation, have shown strong…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Yaroslav Prytula , Illia Tsiporenko , Ali Zeynalli , Dmytro Fishman

Segmentation of white matter lesions and deep grey matter structures is an important task in the quantification of magnetic resonance imaging in multiple sclerosis. In this paper we explore segmentation solutions based on convolutional…

Automating Multiple Sclerosis (MS) lesion segmentation would be of great benefit in initial diagnosis as well as monitoring disease progression. Deep learning based segmentation models perform well in many domains, but the state-of-the-art…

Image and Video Processing · Electrical Eng. & Systems 2024-10-28 Liviu Badea , Maria Popa

Due to the lack of fine-grained annotation guidance, current Multiple Instance Learning (MIL) struggles to establish a robust causal relationship between Whole Slide Image (WSI) diagnosis and evidence sub-images, just like fully supervised…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Tianhang Nan , Yong Ding , Hao Quan , Deliang Li , Lisha Li , Guanghong Zhao , Xiaoyu Cui

Computer-aided segmentation of brain tumors from MRI data is of crucial significance to clinical decision-making in diagnosis, treatment planning, and follow-up disease monitoring. Gliomas, owing to their high malignancy and heterogeneity,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-25 MD Rashidul Islam , Bakary Gibba
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