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In this paper we present a novel framework for sequence to shape maps. These combinatorial maps realize exponentially many shapes, and have preimages which contain extended connected subgraphs of diameter n (neutral networks). We prove that…

Quantitative Methods · Quantitative Biology 2009-09-29 Emma Y. Jin , Jing Qin , Christian M. Reidys

We consider the inverse-folding problem for RNA secondary structures: for a given (pseudo-knot-free) secondary structure find a sequence that has that structure as its ground state. If such a sequence exists, the structure is called…

Biological Physics · Physics 2015-06-26 Bernd Burghardt , Alexander K. Hartmann

Site-specific recombination is an enzymatic process where two sites of precise sequence and orientation along a circle come together, are cleaved, and the ends are recombined. Site-specific recombination on a knotted substrate produces…

Geometric Topology · Mathematics 2018-10-23 Allison H. Moore , Mariel Vazquez

While there has been much interest in adapting conventional clustering procedures---and in higher dimensions, persistent homology methods---to directed networks, little is known about the convergence of such methods. In order to even…

Computational Geometry · Computer Science 2022-12-20 Samir Chowdhury , Facundo Mémoli

Many organisms exhibit branching morphologies that twist around each other and become entangled. Entanglement occurs when different objects interlock, creating complex and often irreversible configurations. This physical phenomenon is…

Approximate pattern matching is a natural and well-studied problem on strings: Given a text $T$, a pattern $P$, and a threshold $k$, find (the starting positions of) all substrings of $T$ that are at distance at most $k$ from $P$. We…

Data Structures and Algorithms · Computer Science 2020-11-17 Panagiotis Charalampopoulos , Tomasz Kociumaka , Philip Wellnitz

In spatial networks vertices are arranged in some space and edges may cross. When arranging vertices in a 1-dimensional lattice edges may cross when drawn above the vertex sequence as it happens in linguistic and biological networks. Here…

Discrete Mathematics · Computer Science 2020-02-24 Lluís Alemany-Puig , Ramon Ferrer-i-Cancho

We study the thermodynamics and kinetics of an RNA toehold-mediated strand displacement reaction with a recently developed coarse-grained model of RNA. Strand displacement, during which a single strand displaces a different strand…

Biological Physics · Physics 2015-03-11 Petr Šulc , Thomas E. Ouldridge , Flavio Romano , Jonathan P. K. Doye , Ard A. Louis

Graph are a ubiquitous data representation, as they represent a flexible and compact representation. For instance, the 3D structure of RNA can be efficiently represented as $\textit{2.5D graphs}$, graphs whose nodes are nucleotides and…

Machine Learning · Computer Science 2021-09-21 Vincent Mallet , Carlos G. Oliver , William L. Hamilton

The formation of secondary structures by a random RNA sequence is studied as a model system for the sequence-structure problem omnipresent in biopolymers. Several toy energy models are introduced to allow detailed analytical and numerical…

Statistical Mechanics · Physics 2009-11-07 R. Bundschuh , T. Hwa

Batched network coding is a low-complexity network coding solution to feedbackless multi-hop wireless packet network transmission with packet loss. The data to be transmitted is encoded into batches where each of which consists of a few…

Information Theory · Computer Science 2022-05-10 Jie Wang , Zhiyuan Jia , Hoover H. F. Yin , Shenghao Yang

Let $\pi_n$ be a uniformly chosen random permutation on $[n]$. Using an analysis of the probability that two overlapping consecutive $k$-permutations are order isomorphic, the authors of a recent paper showed that the expected number of…

Combinatorics · Mathematics 2024-08-07 Anant Godbole , Hannah Swickheimer

This paper is continuation of the systematic study of distribution of quadrant marked mesh patterns initiated in "S. Kitaev and J. Remmel, Quadrant marked mesh patterns, J. Integer Sequences 12, Issue 4 (2012), Article 12.4.7.". We study…

Combinatorics · Mathematics 2012-07-10 Sergey Kitaev , Jeffrey Remmel

Spectral embedding finds vector representations of the nodes of a network, based on the eigenvectors of a properly constructed matrix, and has found applications throughout science and technology. Many networks are multipartite, meaning…

Methodology · Statistics 2025-10-27 Alexander Modell , Ian Gallagher , Joshua Cape , Patrick Rubin-Delanchy

Entangled ring polymers, along with blends of ring and linear polymers, continue to be a topic of great interest and debate due to the conflicting experimental results in the literature as well as the difficulty of producing entangled…

Soft Condensed Matter · Physics 2020-05-27 K. R. Peddireddy , M. Lee , C. M. Schroeder , R. M. Robertson-Anderson

We investigate the longest common substring problem for encoded sequences and its asymptotic behaviour. The main result is a strong law of large numbers for a re-scaled version of this quantity, which presents an explicit relation with the…

Probability · Mathematics 2019-12-12 Adriana Coutinho , Rodrigo Lambert , Jérôme Rousseau

In this paper, we study the distribution of consecutive patterns in the set of 123-avoiding permutations and the set of 132-avoiding permutations, that is, in $\mathcal{S}_n(123)$ and $\mathcal{S}_n(132)$. We first study the distribution of…

Combinatorics · Mathematics 2019-01-07 Ran Pan , Dun Qiu , Jeffrey Remmel

Although both RNA and proteins have densely packed native structures, chain organizations of these two biopolymers are fundamentally different. Motivated by the recent discoveries in chromatin folding that interphase chromosomes have…

Soft Condensed Matter · Physics 2016-12-28 Lei Liu , Changbong Hyeon

Background: The evolution of microRNA regulation in metazoans is a mysterious process: MicroRNA sequences are highly conserved among distal organisms, but on the other hand, there is no evident conservation of their targets. Results: We…

Molecular Networks · Quantitative Biology 2008-02-27 Yonatan Bilu

In evolution, the effects of a single deleterious mutation can sometimes be compensated for by a second mutation which recovers the original phenotype. Such epistatic interactions have implications for the structure of genome space -…

Populations and Evolution · Quantitative Biology 2015-03-19 Steffen Schaper , Iain G. Johnston , Ard A. Louis