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T cells form intriguing patterns during adhesion to antigen-presenting cells. The patterns at the cell-cell contact zone are composed of two types of domains, which either contain short TCR/MHCp receptor-ligand complexes or the longer…

Subcellular Processes · Quantitative Biology 2009-11-10 Thomas R. Weikl , Reinhard Lipowsky

This paper focuses on pattern matching in the DNA sequence. It was inspired by a previously reported method that proposes encoding both pattern and sequence using prime numbers. Although fast, the method is limited to rather small pattern…

Computer Vision and Pattern Recognition · Computer Science 2016-11-21 Janja Paliska Soldo , Ana Sovic Krzic , and Damir Sersic

We examine the conformations of a model for a short segment of closed DNA. The molecule is represented as a cylindrically symmetric elastic rod with a constraint corresponding to a specification of the linking number. We obtain analytic…

Soft Condensed Matter · Physics 2009-10-31 Boris Fain , Joseph Rudnick

Let $\pi_n$ be a uniformly chosen random permutation on $[n]$. The authors of [2] showed that the expected number of distinct consecutive patterns of all lengths $k\in\{1,2,\ldots,n\}$ in $\pi_n$ was $\frac{n^2}{2}(1-o(1))$ as $n\to\infty$,…

Combinatorics · Mathematics 2026-03-31 Verónica Borrás-Serrano , Isabel Byrne , Anant Godbole , Nathaniel Veimau

Bounds on the entropy of patterns of sequences generated by independently identically distributed (i.i.d.) sources are derived. A pattern is a sequence of indices that contains all consecutive integer indices in increasing order of first…

Information Theory · Computer Science 2007-07-13 Gil I. Shamir

Localized patterns are coherent structures embedded in a quiescent state and occur in both discrete and continuous media across a wide range of applications. While it is well-understood how domain covering patterns (for example stripes and…

Pattern Formation and Solitons · Physics 2025-03-19 Jason J. Bramburger , Dan J. Hill , David J. B. Lloyd

Graph symmetries intervene in diverse applications, from enumeration, to graph structure compression, to the discovery of graph dynamics (e.g., node arrival order inference). Whereas Erd\H{o}s-R\'enyi graphs are typically asymmetric, real…

Probability · Mathematics 2018-12-27 Tomasz Luczak , Abram Magner , Wojciech Szpankowski

Nascent adhesions are submicron transient structures promoting the early adhesion of cells to the extracellular matrix. Nascent adhesions typically consist of several tens of integrins, and serve as platforms for the recruitment and…

Subcellular Processes · Quantitative Biology 2021-01-19 Henning Stumpf , Andreja Ambriović-Ristov , Aleksandra Radenovic , Ana-Sunčana Smith

For a Selkov--Schnakenberg model as a prototype reaction-diffusion system on two dimensional domains we use the continuation and bifurcation software pde2path to numerically calculate branches of patterns embedded in patterns, for instance…

Dynamical Systems · Mathematics 2013-10-16 Hannes Uecker , Daniel Wetzel

We propose a new randomized algorithm for solving L2-regularized least-squares problems based on sketching. We consider two of the most popular random embeddings, namely, Gaussian embeddings and the Subsampled Randomized Hadamard Transform…

Machine Learning · Computer Science 2020-10-26 Jonathan Lacotte , Mert Pilanci

A protein residue network (PRN) is a network of interacting amino acids within a protein. We describe characteristics of a sparser, highly central and more volatile sub-network of a PRN called the short-cut network (SCN), as a protein folds…

Molecular Networks · Quantitative Biology 2015-08-13 Susan Khor

Motivation: Non-coding RNAs (ncRNAs) express their functions by adopting molecular structures. Specifically, RNA secondary structures serve as a relatively stable intermediate step before tertiary structures, offering a reliable signature…

Data Structures and Algorithms · Computer Science 2024-02-07 Bertrand Marchand , Yoann Anselmetti , Manuel Lafond , Aïda Ouangraoua

The linking number (topological entanglement) and the writhe (geometrical entanglement) of a model of circular double stranded DNA undergoing a thermal denaturation transition are investigated by Monte Carlo simulations. By allowing the…

Statistical Mechanics · Physics 2007-05-23 M. Baiesi , E. Orlandini , A. L. Stella

Generative probabilistic models emerge as a new paradigm in data-driven, evolution-informed design of biomolecular sequences. This paper introduces a novel approach, called Edge Activation Direct Coupling Analysis (eaDCA), tailored to the…

Biomolecules · Quantitative Biology 2024-04-29 Francesco Calvanese , Camille N. Lambert , Philippe Nghe , Francesco Zamponi , Martin Weigt

Arc-annotated sequences are useful in representing the structural information of RNA and protein sequences. The longest arc-preserving common subsequence problem has been introduced as a framework for studying the similarity of…

Computational Complexity · Computer Science 2011-04-25 Vladimir Yu. Popov

The sequence-dependent elasticity of double-helical DNA on a nm length scale can be captured by the rigid base-pair model, whose strains are the relative position and orientation of adjacent base-pairs. Corresponding elastic potentials have…

Biomolecules · Quantitative Biology 2013-05-29 Nils B. Becker , Ralf Everaers

We consider the problem of counting the occurrences of patterns of the form $xy-z$ within flattened permutations of a given length. Using symmetric functions, we find recurrence relations satisfied by the distributions on $\mathcal{S}_n$…

Combinatorics · Mathematics 2013-06-17 Toufik Mansour , Mark Shattuck , David G. L. Wang

We present TT2NE, a new algorithm to predict RNA secondary structures with pseudoknots. The method is based on a classification of RNA structures according to their topological genus. TT2NE guarantees to find the minimum free energy…

Biomolecules · Quantitative Biology 2010-10-22 Michael Bon , Henri Orland

The intricate network of interactions observed in RNA three-dimensional structures is often described in terms of a multitude of geometrical properties, including helical parameters, base pairing/stacking, hydrogen bonding and backbone…

Biomolecules · Quantitative Biology 2015-09-01 Sandro Bottaro , Francesco Di Palma , Giovanni Bussi

Advances in DNA nanotechnology have stimulated the search for simple motifs that can be used to control the properties of DNA nanostructures. One such motif, which has been used extensively in structures such as polyhedral cages,…

Soft Condensed Matter · Physics 2015-06-10 John S. Schreck , Thomas E. Ouldridge , Flavio Romano , Ard A. Louis , Jonathan P. K. Doye