Related papers: Mathematical Analysis of FLASH Effect Models Based…
FLASH radiotherapy (FLASH-RT) has shown the potential to spare normal tissue while seemingly maintaining the effectiveness of conventional radiotherapy (CONV-RT). It has been suggested that the protective effect arises from the radiolytic…
Starting from a general equation for organism (or cell system) growth and attributing additional cell death rate (besides the natural rate) to therapy, we derive an equation for cell response to {\alpha} radiation. Different from previous…
It has long been known that radiation biology plays an important role and it is necessary for radiotherapy treatments. The radiation effects on normal and malignant tissues after exposure range from a femtosecond to months and years…
We consider physics behind the FLASH modality of cancer radiation treatment where extremely short treatment times are achieved with ultra high dose rates maintaining the conventional antitumor effectiveness and yet substantially reducing…
The FLASH effect, characterized by potential sparing of organs at risk (OAR) through ultra-high dose rate irradiation, has garnered significant attention for its capability to address indications previously untreatable at conventional dose…
Prediction models developed before the introduction of a new treatment may be used to estimate treatment effects of newly introduced treatments. One approach, known as model-based clinical evaluation in radiotherapy, does this by comparing…
In a treatment plan optimization problem for radiotherapy, a clinically acceptable plan is usually generated by an optimization process with weighting factors or reference doses adjusted for organs. Recent discoveries indicate that…
Conventional cancer therapies include surgery, radiation therapy, chemotherapy, and, more recently, immunotherapy. These modalities are often combined to improve the therapeutic index. The general concept of radiation therapy is to increase…
The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any…
Functional data analysis in a mixed-effects model framework is done using operator calculus. In this approach the functional parameters are treated as serially correlated effects giving an alternative to the penalized likelihood approach,…
Understanding transcription factor dynamics is crucial for unraveling the regulatory mechanisms of gene expression that underpin cellular function and development. Measurements of transcription factor subcellular movements are essential for…
We describe an SPH model for chemical enrichment and radiative cooling in cosmological simulations of structure formation. This model includes: i) the delayed gas restitution from stars by means of a probabilistic approach designed to…
Phylogenetic comparative methods explore the relationships between quantitative traits adjusting for shared evolutionary history. This adjustment often occurs through a Brownian diffusion process along the branches of the phylogeny that…
This paper introduces a prognostic method called FLASH that addresses the problem of joint modelling of longitudinal data and censored durations when a large number of both longitudinal and time-independent features are available. In the…
Currently, free flaps and pedicled flaps are assessed for reperfusion in post-operative care using colour, capillary refill, temperature, texture and Doppler signal (if available). While these techniques are effective, they are prone to…
We investigated the effects of scanning speed, beam configuration, and dose-rate modeling on the FLASH effect in post-mastectomy proton transmission-beam (TB) planning and evaluated whether optimizing the spot-scanning path can enhance…
We develop and analyze a mathematical model of oncolytic virotherapy in the treatment of melanoma. We begin with a special, local case of the model, in which we consider the dynamics of the tumour cells in the presence of an oncolytic virus…
X-ray observations are a direct diagnostic of fast electrons produced in solar flares, energized during the energy release process and directed towards the Sun. Since the properties of accelerated electrons can be substantially changed…
Developmental epidemiology commonly focuses on assessing the association between multiple early life exposures and childhood health. Statistical analyses of data from such studies focus on inferring the contributions of individual…
Exercise rehabilitation is an important part in the comprehensive management of patients with diabetes and there is a need to conduct comprehensively evaluation of several factors such as the physical fitness, cardiovascular risk and…