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Diffusion models are important in tissue engineering as they enable an understanding of molecular delivery to cells in tissue constructs. As three-dimensional (3D) tissue constructs become larger, more intricate, and more clinically…

Tissues and Organs · Quantitative Biology 2015-12-22 Richard J. McMurtrey

This study presents the approach to analyzing the evolution of an arbitrary complex system whose behavior is characterized by a set of different time-dependent factors. The key requirement for these factors is only that they must contain an…

Data Analysis, Statistics and Probability · Physics 2020-12-01 Anatolii V. Mokshin , Vladimir V. Mokshin , Diana A. Mirziyarova

Treatment-related lymphopenia is a frequent and clinically significant consequence of cancer therapy that can compromise immune-mediated tumor control and worsen patient outcomes. Despite its importance, no mechanistic framework exists to…

Medical Physics · Physics 2026-05-04 Vladislav Sandul , Marco Durante , Thomas Friedrich

{\bf Purpose}: To develop a geometry-governed diffusion framework that explains differential tissue response under FLASH ultra-high dose rate (UHDR) irradiation by explicitly accounting for structural heterogeneity and anomalous transport…

Medical Physics · Physics 2026-04-20 Neda Valizadeh , Robabeh Rahimi , Ramin Abolfath

In this series of three papers we present results from a combined experimental and theoretical effort to quantitatively describe capacitively coupled radio-frequency discharges in oxygen. The particle-in-cell Monte-Carlo model on which the…

Plasma Physics · Physics 2009-11-13 F. X. Bronold , K. Matyash , D. Tskhakaya , R. Schneider , H. Fehske

The self-consistent inclusion of plasma effects in opacity calculations is a significant modeling challenge. As density increases, such effects can no longer be treated perturbatively. Building on a recently published model that addresses…

Plasma Physics · Physics 2024-10-08 C. E. Starrett , C. J. Fontes , H. B. Tran Tan , J. M. Kasper , J. R. White

In this article, we investigate group differences in phthalate exposure profiles using NHANES data. Phthalates are a family of industrial chemicals used in plastics and as solvents. There is increasing evidence of adverse health effects of…

Methodology · Statistics 2020-12-03 Arkaprava Roy , Isaac Lavine , Amy H. Herring , David B. Dunson

Fluorescence recovery after photobleaching (FRAP) measurements offer an important tool for analyzing diffusion and binding processes. Confocal scanning laser microscopes that are used in FRAP experiments bleach regions with a radially…

Subcellular Processes · Quantitative Biology 2009-03-09 George D Tsibidis

Purpose: Factor analysis (FA) has become part and parcel in metabolic syndrome (MBS) research. Both exploration- and confirmation-driven factor analyzes are rampant. However, factor analytic results on MBS differ widely. A situation that is…

Applications · Statistics 2016-09-09 Carel F. W. Peeters , James Dziura , Floryt van Wesel

Factor analysis is a critical component of high dimensional biological data analysis. However, modern biological data contain two key features that irrevocably corrupt existing methods. First, these data, which include longitudinal,…

Methodology · Statistics 2020-09-24 Chris McKennan

The Vlasov equation embodies the smooth field approximation of the self-consistent equation of motion for charged particle beams. This framework is fundamentally altered if we include the fluctuating forces that originate from the actual…

Accelerator Physics · Physics 2023-04-26 Jürgen Struckmeier

Solar flares are large-scale releases of energy in the solar atmosphere, which are characterised by rapid changes in the hydrodynamic properties of plasma from the photosphere to the corona. Solar physicists have typically attempted to…

Solar and Stellar Astrophysics · Physics 2012-06-26 S. Adamakis , C. L. Raftery , R. W. Walsh , P. T. Gallagher

Functional factor analysis is an important dimension reduction method for functional and longitudinal data. Factor loadings give insight into patterns of variability of the observations, while latent factors provide a low-dimensional…

Methodology · Statistics 2026-04-29 James Matuk , Amy H. Herring , David B. Dunson

Plasma sheaths driven by radio-frequency voltages occur frequently, in contexts ranging from plasma processing applications to magnetically confined fusion experiments. These sheaths are crucial because they dominantly affect impedance,…

Plasma Physics · Physics 2012-12-12 Miles M. Turner , Pascal Chabert

We present an algorithm for solving the radiative transfer problem on massively parallel computers using adaptive mesh refinement and domain decomposition. The solver is based on the method of characteristics which requires an adaptive…

Astrophysics of Galaxies · Physics 2015-08-13 Lars Buntemeyer , Robi Banerjee , Thomas Peters , Mikhail Klassen , Ralph E. Pudritz

Optical Emission Spectroscopy is a widely used technique for plasma diagnosis, with particular interest in hydrogen atomic emission due to its prevalence in plasmas. However, accurately determining plasma parameters like electron density,…

Plasma Physics · Physics 2025-01-22 A. Sarsa , A. Jiménez-Solano , M. S. Dimitrijević , C. Yubero

Realistic modeling of ionic systems necessitates taking explicitly account of many-body effects. In molecular dynamics simulations, it is possible to introduce explicitly these effects through the use of additional degrees of freedom. Here…

A novel hydraulic fracture (HF) formulation is introduced which accounts for the hydraulically induced shear stress at the crack faces. It utilizes a general form of the elasticity operator alongside a revised fracture propagation condition…

Geophysics · Physics 2016-12-13 Michal Wrobel , Gennady Mishuris , Andrea Piccolroaz

Biophysical models describing complex, cellular phenomena typically include systems of nonlinear differential equations with many free parameters. While experimental measurements can fix some parameters, those describing internal cellular…

Computational Physics · Physics 2025-07-08 Joseph M. Marcinik , Martín A. Toderi , Dolores Bozovic

The pattern of radiation energy deposition in substances at the microscopic level of lattice, molecule size, or the cell's nucleus is not uniform. The energy of radiation is transferred to the substance medium in the form of discrete,…

Medical Physics · Physics 2022-10-14 Elsayed K. Elmaghraby , Mohamed Bahaaeldin-Afifi