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Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to…

Large Language Models (LLMs) are increasingly utilized for mental health support; however, current safety benchmarks often fail to detect the complex, longitudinal risks inherent in therapeutic dialogue. We introduce an evaluation framework…

Computation and Language · Computer Science 2026-03-06 Ian Steenstra , Paola Pedrelli , Weiyan Shi , Stacy Marsella , Timothy W. Bickmore

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

Computation and Language · Computer Science 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

This study compares the efficacy of GPT-4 and clinalytix Medical AI in predicting the clinical risk of delirium development. Findings indicate that GPT-4 exhibited significant deficiencies in identifying positive cases and struggled to…

Computation and Language · Computer Science 2024-09-17 Mohamed Rezk , Patricia Cabanillas Silva , Fried-Michael Dahlweid

Background Major depressive disorder (MDD) is a leading cause of global disability, yet current diagnostic approaches often rely on subjective assessments and lack the ability to integrate multimodal clinical information. Large language…

Machine Learning · Computer Science 2025-09-30 Yuyang Sha , Hongxin Pan , Gang Luo , Caijuan Shi , Jing Wang , Kefeng Li

Large language models (LLMs) have demonstrated unprecedented emergent capabilities, including content generation, translation, and simulation of human behavior. Field experiments, on the other hand, are widely employed in social studies to…

Computers and Society · Computer Science 2025-05-22 Yaoyu Chen , Yuheng Hu , Yingda Lu

As language models (LMs) become increasingly powerful and widely used, it is important to quantify them for sociodemographic bias with potential for harm. Prior measures of bias are sensitive to perturbations in the templates designed to…

Computation and Language · Computer Science 2024-08-09 Vipul Gupta , Pranav Narayanan Venkit , Hugo Laurençon , Shomir Wilson , Rebecca J. Passonneau

Large language models (LLMs) are increasingly used in clinical and care settings. This exploratory study investigates whether LLMs exhibit sycophantic behavior - adapting their responses to social expectation signals rather than maintaining…

Computers and Society · Computer Science 2026-05-19 Christian Kolb

The advancement of large language models (LLMs) has demonstrated strong capabilities across various applications, including mental health analysis. However, existing studies have focused on predictive performance, leaving the critical issue…

Computation and Language · Computer Science 2024-06-21 Yuqing Wang , Yun Zhao , Sara Alessandra Keller , Anne de Hond , Marieke M. van Buchem , Malvika Pillai , Tina Hernandez-Boussard

Large language models (LLMs) have made significant progress in various domains, including healthcare. However, the specialized nature of clinical language understanding tasks presents unique challenges and limitations that warrant further…

Computation and Language · Computer Science 2023-08-01 Yuqing Wang , Yun Zhao , Linda Petzold

The application of large language models (LLMs) in healthcare has gained significant attention due to their ability to process complex medical data and provide insights for clinical decision-making. These models have demonstrated…

Computer Vision and Pattern Recognition · Computer Science 2024-09-26 Amna Khalid , Ayma Khalid , Umar Khalid

Evaluating Large Language Models (LLMs) for mental health support is challenging due to the emotionally and cognitively complex nature of therapeutic dialogue. Existing benchmarks are limited in scale, reliability, often relying on…

Large Language Models (LLMs) have recently displayed their extraordinary capabilities in language understanding. However, how to comprehensively assess the sentiment capabilities of LLMs continues to be a challenge. This paper investigates…

Computation and Language · Computer Science 2025-02-17 Yang Liu , Xichou Zhu , Zhou Shen , Yi Liu , Min Li , Yujun Chen , Benzi John , Zhenzhen Ma , Tao Hu , Zhi Li , Zhiyang Xu , Wei Luo , Junhui Wang

Large language models (LLMs) are increasingly used to support the analysis of complex financial disclosures, yet their reliability, behavioral consistency, and transparency remain insufficiently understood in high-stakes settings. This…

Computation and Language · Computer Science 2026-01-21 Md Talha Mohsin

Large Language Models (LLMs) and causal learning each hold strong potential for clinical decision making (CDM). However, their synergy remains poorly understood, largely due to the lack of systematic benchmarks evaluating their integration…

Machine Learning · Computer Science 2025-11-14 Linna Wang , Zhixuan You , Qihui Zhang , Jiunan Wen , Ji Shi , Yimin Chen , Yusen Wang , Fanqi Ding , Ziliang Feng , Li Lu

The global mental health crisis is looming with a rapid increase in mental disorders, limited resources, and the social stigma of seeking treatment. As the field of artificial intelligence (AI) has witnessed significant advancements in…

Computation and Language · Computer Science 2023-11-27 Neo Christopher Chung , George Dyer , Lennart Brocki

Accurate and interpretable detection of depressive language in social media is useful for early interventions of mental health conditions, and has important implications for both clinical practice and broader public health efforts. In this…

Computation and Language · Computer Science 2025-06-10 Samuel Kim , Oghenemaro Imieye , Yunting Yin

Behavioral simulation is increasingly used to anticipate responses to interventions. Large language models (LLMs) enable researchers to specify population characteristics and intervention context in natural language, but it remains unclear…

Computers and Society · Computer Science 2026-04-14 Zonghan Li , Feng Ji

As Large Language Models (LLMs) become increasingly integrated into our everyday lives, understanding their ability to comprehend human mental states becomes critical for ensuring effective interactions. However, despite the recent attempts…

Computation and Language · Computer Science 2023-12-06 Kanishk Gandhi , Jan-Philipp Fränken , Tobias Gerstenberg , Noah D. Goodman

Recent work has investigated the capabilities of large language models (LLMs) as zero-shot models for generating individual-level characteristics (e.g., to serve as risk models or augment survey datasets). However, when should a user have…