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Studying the complex interactions between different brain regions is crucial in neuroscience. Various statistical methods have explored the latent communication across multiple brain regions. Two main categories are the Gaussian Process…

Neurons and Cognition · Quantitative Biology 2024-05-31 Weihan Li , Chengrui Li , Yule Wang , Anqi Wu

Magnetic resonance spectroscopy (MRS) is an established technique for studying tissue metabolism, particularly in central nervous system disorders. While powerful and versatile, MRS is often limited by challenges associated with data…

Quantitative Methods · Quantitative Biology 2024-08-29 Christopher J. Wu , Lawrence S. Kegeles , Jia Guo

Modeling the time-series of high-dimensional, longitudinal data is important for predicting patient disease progression. However, existing neural network based approaches that learn representations of patient state, while very flexible, are…

Machine Learning · Computer Science 2021-06-21 Zeshan Hussain , Rahul G. Krishnan , David Sontag

Remote Photoplethysmography (rPPG) enables non-contact physiological signal extraction from facial videos, offering applications in psychological state analysis, medical assistance, and anti-face spoofing. However, challenges such as motion…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Zhixin Yan , Yan Zhong , Hongbin Xu , Wenjun Zhang , Shangru Yi , Lin Shu , Wenxiong Kang

Data-driven approaches for remote detection of Parkinson's Disease and its motor symptoms have proliferated in recent years, owing to the potential clinical benefits of early diagnosis. The holy grail of such approaches is the free-living…

Machine Learning · Computer Science 2023-05-02 Alexandros Papadopoulos , Anastasios Delopoulos

Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and…

Quantitative Methods · Quantitative Biology 2019-11-11 Devin Taylor , Simeon Spasov , Pietro Liò

Static disorder plays a crucial role in the electronic dynamics and spectroscopy of complex molecular systems. Traditionally, obtaining observables averaged over static disorder requires thousands of realizations via direct sampling of the…

Chemical Physics · Physics 2025-06-10 Zhao Zhang , Jiajun Ren , Wei-Hai Fang

Multi-output Gaussian processes (GPs) are a flexible Bayesian nonparametric framework that has proven useful in jointly modeling the physiological states of patients in medical time series data. However, capturing the short-term effects of…

The current body of research on Parkinson's disease (PD) screening, monitoring, and management has evolved along two largely independent trajectories. The first research community focuses on multimodal sensing of PD-related biomarkers using…

Signal Processing · Electrical Eng. & Systems 2025-11-11 Hassan Hizeh , Rim Chighri , Muhammad Mahboob Ur Rahman , Mohamed A. Bahloul , Ali Muqaibel , Tareq Y. Al-Naffouri

Passive and non-obtrusive health monitoring using wearables can potentially bring new insights into the user's health status throughout the day and may support clinical diagnosis and treatment. However, identifying segments of free-living…

Signal Processing · Electrical Eng. & Systems 2019-01-31 Yordan P. Raykov , Luc J. W. Evers , Reham Badawy , Marjan J. Faber , Bastiaan R. Bloem , Kasper Claes , Max A. Little

Parkinsons disease, PD, is a chronic condition that affects motor skills and includes symptoms like tremors and rigidity. The current diagnostic procedure uses patient assessments to evaluate symptoms and sometimes a magnetic resonance…

Image and Video Processing · Electrical Eng. & Systems 2022-01-14 Sabrina Zhu

Adaptive deep brain stimulation (aDBS) has emerged as a promising treatment for Parkinson disease (PD). In aDBS, a surgically placed electrode sends dynamically altered stimuli to the brain based on neurophysiological feedback: an invasive…

Neurons and Cognition · Quantitative Biology 2025-05-16 Ekaterina Kuzmina , Dmitrii Kriukov , Mikhail Lebedev , Dmitry V. Dylov

Latent Space (LS) network models project the nodes of a network on a $d$-dimensional latent space to achieve dimensionality reduction of the network while preserving its relevant features. Inference is often carried out within a Markov…

Computation · Statistics 2024-08-23 Roberto Casarin , Antonio Peruzzi

Many applications in medical statistics as well as in other fields can be described by transitions between multiple states (e.g. from health to disease) experienced by individuals over time. In this context, multi-state models are a popular…

Continuous collection of physiological data from wearable sensors enables temporal characterization of individual behaviors. Understanding the relation between an individual's behavioral patterns and psychological states can help identify…

Using projected entangled-pair states (PEPS) we analyze the localization properties of two-dimensional systems on a square lattice. We compare the dynamics found for three different disorder types: (i) quenched disorder, (ii) sum of two…

Disordered Systems and Neural Networks · Physics 2018-11-13 D. M. Kennes

In electronic health records (EHRs), latent subgroups of patients may exhibit distinctive patterning in their longitudinal health trajectories. For such data, growth mixture models (GMMs) enable classifying patients into different latent…

Methodology · Statistics 2022-01-12 Rebecca Anthopolos , Ying Wei , Qixuan Chen

Mobile technology (e.g., mobile phones and wearable devices) provides scalable methods for collecting physiological and behavioral biomarkers in patients' naturalistic settings, as well as opportunities for therapeutic advancements and…

Remote photoplethysmography (rPPG) based physiological measurement has great application values in affective computing, non-contact health monitoring, telehealth monitoring, etc, which has become increasingly important especially during the…

Human-Computer Interaction · Computer Science 2022-06-22 Yuhang Dong , Gongping Yang , Yilong Yin

Continuous-time multistate models are widely used for analyzing interval-censored data on disease progression over time. Sometimes, diseases manifest differently and what appears to be a coherent collection of symptoms is the expression of…

Methodology · Statistics 2024-10-08 Yidan Shi , Leilei Zeng , Mary E. Thompson , Suzanne L. Tyas