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Parkinson's disease (PD) affects over ten million people worldwide. Although temporal interference (TI) and deep brain stimulation (DBS) are promising therapies, inter-individual variability limits empirical treatment selection, increasing…

Neurons and Cognition · Quantitative Biology 2026-04-01 Siyuan Du , Siyi Li , Shuwei Bai , Ang Li , Haolin Li , Mingqing Xiao , Yang Pan , Dongsheng Li , Weidi Xie , Yanfeng Wang , Ya Zhang , Chencheng Zhang , Jiangchao Yao

Resistive Pulse Sensing (RPS) is a key label-free technology to measure particles and single-cell size distribution. As a growing corpus of evidence supports that cancer cells exhibit distinct mechanical phenotypes from healthy cells,…

Biological Physics · Physics 2020-04-01 Antoine Riaud , Anh L. P. Thai , Wei Wang , Valerie Taly

The stage and severity of Parkinson's disease (PD) is an important factor to consider for taking effective therapeutic decisions. Although the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) provides an…

Applications · Statistics 2018-05-30 R. Prashanth , Sumantra Dutta Roy

Continuous-time state-space models (SSMs) are flexible tools for analysing irregularly sampled sequential observations that are driven by an underlying state process. Corresponding applications typically involve restrictive assumptions…

Methodology · Statistics 2020-10-29 Sina Mews , Roland Langrock , Marius Ötting , Houda Yaqine , Jost Reinecke

Multiple instance learning is an ideal mode of analysis for histopathology data, where vast whole slide images are typically annotated with a single global label. In such cases, a whole slide image is modelled as a collection of tissue…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Leo Fillioux , Joseph Boyd , Maria Vakalopoulou , Paul-Henry Cournède , Stergios Christodoulidis

Capturing the inter-dependencies among multiple types of clinically-critical events is critical not only to accurate future event prediction, but also to better treatment planning. In this work, we propose a deep latent state-space…

Machine Learning · Computer Science 2024-07-30 Yuan Xue , Denny Zhou , Nan Du , Andrew M. Dai , Zhen Xu , Kun Zhang , Claire Cui

In network meta-analysis (NMA), we synthesize all relevant evidence about health outcomes with competing treatments. The evidence may come from randomized controlled trials (RCT) or non-randomized studies (NRS) as individual participant…

Parkinson's disease (PD), a severe and progressive neurological illness, affects millions of individuals worldwide. For effective treatment and management of PD, an accurate and early diagnosis is crucial. This study presents a deep…

Signal Processing · Electrical Eng. & Systems 2023-08-16 Niloufar Delfan , Mohammadreza Shahsavari , Sadiq Hussain , Robertas Damaševičius , U. Rajendra Acharya

Joint modelling of longitudinal and survival data is increasingly used in clinical trials on cancer. In prostate cancer for example, these models permit to account for the link between longitudinal measures of prostate-specific antigen…

Recently, the diffusion-based generative paradigm has achieved impressive general image generation capabilities with text prompts due to its accurate distribution modeling and stable training process. However, generating diverse remote…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Jialin Luo , Yuanzhi Wang , Ziqi Gu , Yide Qiu , Shuaizhen Yao , Fuyun Wang , Chunyan Xu , Wenhua Zhang , Dan Wang , Zhen Cui

In recent years, sensors from smart consumer devices have shown great diagnostic potential in movement disorders. In this context, data modalities such as electronic questionnaires, hand movement and voice captures have successfully…

Machine Learning · Computer Science 2022-05-13 Catharina Marie van Alen , Alexander Brenner , Tobias Warnecke , Julian Varghese

A state-space model is a time-series model that has an unobserved latent process from which we take noisy measurements over time. The observations are conditionally independent given the latent process and the latent process itself is…

Methodology · Statistics 2025-10-07 Paul Fearnhead , Chris Sherlock

Not only does mobile health technology enable researchers to track changes in multiple longitudinal outcomes of interest and to record the occurrence of health-related events over time, but it also allows for the delivery of repeated…

Accurate evaluation of Parkinsons disease (PD) severity is essential for effective clinical management and intervention development. Despite the proposal of several gesture based PD recognition systems, including those using the finger…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Abu Saleh Musa Miah , Najmul Hassan , Md Maruf Al Hossain , Yuichi Okuyama , Jungpil Shin

The matrix product state (MPS) is utilized to study the ground state properties and quantum phase transitions (QPTs) of the one-dimensional quantum compass model (QCM). The MPS wavefunctions are argued to be very efficient descriptions of…

Strongly Correlated Electrons · Physics 2012-06-05 Guang-Hua Liu , Wei Li , Wen-Long You , Guang-Shan Tian , Gang Su

Brain network discovery aims to find nodes and edges from the spatio-temporal signals obtained by neuroimaging data, such as fMRI scans of human brains. Existing methods tend to derive representative or average brain networks, assuming…

Machine Learning · Computer Science 2023-11-07 Hang Yin , Yao Su , Xinyue Liu , Thomas Hartvigsen , Yanhua Li , Xiangnan Kong

Mouse-tracking recording techniques are becoming very attractive in experimental psychology. They provide an effective means of enhancing the measurement of some real-time cognitive processes involved in categorization, decision-making, and…

Applications · Statistics 2019-12-18 Antonio Calcagnì , Luigi Lombardi , Marco D'Alessandro

Clinical characterization and interpretation of respiratory sound symptoms have remained a challenge due to the similarities in the audio properties that manifest during auscultation in medical diagnosis. The misinterpretation and…

Systems and Control · Electrical Eng. & Systems 2021-10-18 Chinazunwa Uwaoma , Gunjan Mansingh

The rapid advancement of medical technology has led to an exponential increase in multi-modal medical data, including imaging, genomics, and electronic health records (EHRs). Graph neural networks (GNNs) have been widely used to represent…

Quantitative Methods · Quantitative Biology 2024-10-03 Favour Nerrise , Alice Louise Heiman , Ehsan Adeli

Multi-modal biomedical time series (MBTS) data offers a holistic view of the physiological state, holding significant importance in various bio-medical applications. Owing to inherent noise and distribution gaps across different modalities,…

Machine Learning · Computer Science 2023-12-08 Hongbo Guo , Xinzi Xu , Hao Wu , Guoxing Wang
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